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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 3
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Research Article

Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey

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Pages 270-277 | Received 19 Aug 2014, Accepted 01 Oct 2014, Published online: 22 Oct 2014

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Tomonori Miura, Yusuke Kamiya, Shotaro Uehara, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu & Hiroshi Yamazaki. (2021) Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models. Xenobiotica 51:6, pages 636-642.
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Akiko Toda, Makiko Shimizu, Shotaro Uehara, Tatsuro Sasaki, Tomonori Miura, Masayuki Mogi, Masahiro Utoh, Hiroshi Suemizu & Hiroshi Yamazaki. (2021) Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling. Xenobiotica 51:3, pages 316-323.
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Xu Wang, Qinghua Wu, Aimei Liu, Arturo Anadón, José-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Zonghui Yuan & María-Aránzazu Martínez. (2017) Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro. Drug Metabolism Reviews 49:4, pages 395-437.
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Articles from other publishers (9)

David Juan, Gabriel Santpere, Joanna L. Kelley, Omar E. Cornejo & Tomas Marques-Bonet. (2023) Current advances in primate genomics: novel approaches for understanding evolution and disease. Nature Reviews Genetics 24:5, pages 314-331.
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Heng-Keang Lim, Jie Chen, Wing Lam, Yong Gong, Laurent Leclercq, Jose Silva, Rhys Salter, Joris Berwaerts, Cathy K. Gelotte, Amy M. Vakil, Gary E. Eichenbaum, Edwin K. Kuffner & Christopher M. Flores. (2023) Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans. Regulatory Toxicology and Pharmacology, pages 105379.
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Junguo Zhou, Sandra De Jonghe, Ellen E. Codd, Sandy Weiner, David Gallacher, Paul Stahle, Michael F. Kelley, Edwin K. Kuffner, Christopher M. Flores & Gary E. Eichenbaum. (2023) Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses. Regulatory Toxicology and Pharmacology, pages 105334.
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Joshua Hefler, Braulio A. Marfil-Garza, Rena L. Pawlick, Darren H. Freed, Constantine J. Karvellas, David L. Bigam & A. M. James Shapiro. (2021) Preclinical models of acute liver failure: a comprehensive review. PeerJ 9, pages e12579.
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Yitian Zhou, Joanne X. Shen & Volker M. Lauschke. (2019) Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury. Frontiers in Pharmacology 10.
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Lei Feng, Lei Cai, Guo-Lin He, Jun Weng, Yang Li, Ming-Xin Pan, Ze-Sheng Jiang, Qing Peng & Yi Gao. (2017) Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure. World Journal of Gastroenterology 23:42, pages 7572-7583.
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Kathryn Pickup, Scott Martin, Elizabeth A. Partridge, Huw B. Jones, Jonathan Wills, Tim Schulz-Utermoehl, Alan McCarthy, Alison Rodrigues, Chris Page, Kerry Ratcliffe, Sunil Sarda & Ian D. Wilson. (2016) Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice. Archives of Toxicology 91:7, pages 2643-2653.
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Lars Weidolf & Ian D. Wilson. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development 141 176 .
Michelle Hudson-Shore. (2016) Statistics of Scientific Procedures on Living Animals 2014 : A New Format, and Hopefully a New Era of Diminishing Animal Experimentation? . Alternatives to Laboratory Animals 44:1, pages 71-83.
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