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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 3
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Research Article

In vitro profiling of the metabolism and drug–drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP

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Pages 230-238 | Received 20 Aug 2014, Accepted 09 Oct 2014, Published online: 28 Oct 2014

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Tomoyuki Kawachi, Mizuki Ninomiya, Takayuki Katsube, Toshihiro Wajima & Takushi Kanazu. (2021) Human mass balance, metabolism, and cytochrome P450 phenotyping of lusutrombopag. Xenobiotica 51:3, pages 287-296.
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Kalliopi Pafili, Efstratios Maltezos & Nikolaos Papanas. (2016) Pharmacokinetic and pharmacodynamic drug evaluation of tofogliflozin for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 12:11, pages 1367-1380.
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Yasushi Yamazoe & Kouichi Yoshinari. (2024) Construction of a fused grid-based CYP2C18-Template system and its application to drug metabolism. Drug Metabolism and Pharmacokinetics 54, pages 100534.
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Lei Sun, Kun Mi, Yixuan Hou, Tianyi Hui, Lan Zhang, Yanfei Tao, Zhenli Liu & Lingli Huang. (2023) Pharmacokinetic and Pharmacodynamic Drug–Drug Interactions: Research Methods and Applications. Metabolites 13:8, pages 897.
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Pablo Zubiaur & Andrea Gaedigk. (2022) CYP2C18: the orphan in the CYP2C family. Pharmacogenomics 23:17, pages 913-916.
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Mortaza F. Hassanabad & Mohammad Fatehi. (2020) Androgen Therapy in Male Patients Suffering from Type 2 Diabetes: A Review of Benefits and Risks. Current Diabetes Reviews 16:3, pages 189-199.
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Masatoshi Murakata, Akira Kawase, Nobuaki Kimura, Takuma Ikeda, Masahiro Nagase, Masatoshi Koizumi, Kazuaki Kuwata, Kenji Maeda & Hitoshi Shimizu. (2019) Synthesis of Tofogliflozin as an SGLT2 Inhibitor via Construction of Dihydroisobenzofuran by Intramolecular [4 + 2] Cycloaddition. Organic Process Research & Development 23:4, pages 548-557.
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Yoshihiko Yamamoto. 2019. Carbohydrate-spiro-heterocycles. Carbohydrate-spiro-heterocycles 215 260 .
Satoshi Yamaori, Noriyuki Araki, Mio Shionoiri, Kurumi Ikehata, Shinobu Kamijo, Shigeru Ohmori & Kazuhito Watanabe. (2018) A Specific Probe Substrate for Evaluation of CYP4A11 Activity in Human Tissue Microsomes and a Highly Selective CYP4A11 Inhibitor: Luciferin-4A and Epalrestat. Journal of Pharmacology and Experimental Therapeutics 366:3, pages 446-457.
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Masatoshi Murakata, Takuma Ikeda, Nobuaki Kimura, Akira Kawase, Masahiro Nagase, Masahiro Kimura, Kenji Maeda, Akie Honma & Hitoshi Shimizu. (2017) The regioselective bromine-lithium exchange reaction of alkoxymethyldibromobenzene: A new strategy for the synthesis of tofogliflozin as a SGLT2 inhibitor for the treatment of diabetes. Tetrahedron 73:6, pages 655-660.
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Stephen Fowler, Peter N. Morcos, Yumi Cleary, Meret Martin-Facklam, Neil Parrott, Michael Gertz & Li Yu. (2017) Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities. Current Pharmacology Reports 3:1, pages 36-49.
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M. Ruscica, L. Baldessin, D. Boccia, G. Racagni & N. Mitro. (2017) Non-insulin anti-diabetic drugs: An update on pharmacological interactions. Pharmacological Research 115, pages 14-24.
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Yoshihito Ohtake, Takashi Emura, Masahiro Nishimoto, Koji Takano, Keisuke Yamamoto, Satoshi Tsuchiya, Sang-Yong Yeu, Yasushi Kito, Nobuaki Kimura, Sunao Takeda, Masao Tsukazaki, Masatoshi Murakata & Tsutomu Sato. (2016) Development of a Scalable Synthesis of Tofogliflozin. The Journal of Organic Chemistry 81:5, pages 2148-2153.
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Jian Xiao, Dan Chen, Xiu-Xian Lin, Shi-Fang Peng, Mei-Fang Xiao, Wei-Hua Huang, Yi-Cheng Wang, Jing-Bo Peng, Wei Zhang, Dong-Sheng Ouyang & Yao Chen. (2016) Screening of Drug Metabolizing Enzymes for the Ginsenoside Compound K In Vitro: An Efficient Anti-Cancer Substance Originating from Panax Ginseng. PLOS ONE 11:2, pages e0147183.
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