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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 10
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General Xenobiochemistry

Decreased exposure of atorvastatin in diabetic rats partly due to induction of hepatic Cyp3a and Oatp2

Nan ShuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China,
,
Mengyue HuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China,
,
Can LiuDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA, and
,
Mian ZhangCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China,
,
Zhaoli LingCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China,
,
Ji ZhangDepartment of Pharmacy, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China
,
Ping XuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China,
,
Zeyu ZhongCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China,
,
Yang ChenCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China,
,
Li LiuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China, Correspondence[email protected] [email protected]
&
Xiaodong LiuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China, Correspondence[email protected] [email protected]
 show all
Pages 875-881 | Received 02 Dec 2015, Accepted 10 Jan 2016, Published online: 10 Feb 2016

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Congyang Ding, Yajing Li, Xiao Li, Lu Meng, Ran Fu, Xiaonan Wang, Ying Li, Yinling Ma & Zhanjun Dong. (2022) QiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats. Pharmaceutical Biology 60:1, pages 185-194.
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Neel Deferm, Tom De Vocht, Bing Qi, Pieter Van Brantegem, Eva Gijbels, Mathieu Vinken, Peter de Witte, Thomas Bouillon & Pieter Annaert. (2019) Current insights in the complexities underlying drug-induced cholestasis. Critical Reviews in Toxicology 49:6, pages 520-548.
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Articles from other publishers (14)

Zhe Wang, Qing-qing Li, Cheng-ke Huang, Yan-yan Dong, Li-ping Lang, Wei Sun, Jian-chang Qian & Xiao-dan Zhang. (2023) Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis 224, pages 115191.
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Pelageya D. Erokhina, Pavel Yu. Myl’nikov, Svetlana O. Ganina, Egor A. Konyakhin, Aleksey V. Shchul’kin, Alexandr A. Slepnev & Elena N. Yakusheva. (2022) Development and Validation of the Quantitative Determination of Atorvastatin in HepG2 Cell Line Using High-Performance Liquid Chromatography with Mass-Spectrometric Detection. I.P. Pavlov Russian Medical Biological Herald 30:2.
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Habibeh Mashayekhi-Sardoo, Stephen L. Atkin, Fabrizio Montecucco & Amirhossein Sahebkar. (2021) Potential Alteration of Statin-Related Pharmacological Features in Diabetes Mellitus. BioMed Research International 2021, pages 1-9.
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Abhishek Gour, Ashish Dogra, Sumit Sharma, Priya Wazir & Utpal Nandi. (2021) Effect of Disease State on the Pharmacokinetics of Bedaquiline in Renal-Impaired and Diabetic Rats. ACS Omega 6:10, pages 6934-6941.
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Hsien-Tsung Yao, Ya-Ru Hsu & Mei-Ling Li. (2020) Beverage–Drug Interaction: Effects of Green Tea Beverage Consumption on Atorvastatin Metabolism and Membrane Transporters in the Small Intestine and Liver of Rats. Membranes 10:9, pages 233.
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Yiting Yang & Xiaodong Liu. (2020) Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance. Pharmaceutics 12:4, pages 348.
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Yuhua Li, Qiang Meng, Mengbi Yang, Dongyang Liu, Xiangyu Hou, Lan Tang, Xin Wang, Yuanfeng Lyu, Xiaoyan Chen, Kexin Liu, Ai-Ming Yu, Zhong Zuo & Huichang Bi. (2019) Current trends in drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B 9:6, pages 1113-1144.
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Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Yang Chen, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang, Xiaodong Liu & Li Liu. (2019) Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters. Drug Metabolism and Disposition 47:10, pages 1066-1079.
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Feng Xu, Liang Zhu, Chaoqun Qian, Junjie Zhou, Donghao Geng, Ping Li, Wenjing Xuan, Fangge Wu, Kaijing Zhao, Weimin Kong, Yuanyuan Qin, Limin Liang, Li Liu & Xiaodong Liu. (2019) Impairment of Intestinal Monocarboxylate Transporter 6 Function and Expression in Diabetic Rats Induced by Combination of High-Fat Diet and Low Dose of Streptozocin: Involvement of Butyrate–Peroxisome Proliferator-Activated Receptor- γ Activation . Drug Metabolism and Disposition 47:6, pages 556-566.
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Lei Zhang, Peipei Xu, Yi Cheng, Peili Wang, Xinrun Ma, Mingyao Liu, Xin Wang & Feng Xu. (2019) Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats. Biochemical Pharmacology 164, pages 368-376.
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Xiaodong Liu. 2019. Drug Transporters in Drug Disposition, Effects and Toxicity. Drug Transporters in Drug Disposition, Effects and Toxicity 101 202 .
Xue Wang, Fangyu Wang, Yidan Zhang, Hui Xiong, Yanjun Zhang, Pengwei Zhuang & Youcai Zhang. (2018) Diabetic cognitive dysfunction is associated with increased bile acids in liver and activation of bile acid signaling in intestine. Toxicology Letters 287, pages 10-22.
Crossref
Binbin Sun, Zeyu Zhong, Fan Wang, Jiong Xu, Feng Xu, Weimin Kong, Zhaoli Ling, Nan Shu, Ying Li, Tong Wu, Mian Zhang, Liang Zhu, Xiaodong Liu & Li Liu. (2018) Atorvastatin impaired glucose metabolism in C2C12 cells partly via inhibiting cholesterol-dependent glucose transporter 4 translocation. Biochemical Pharmacology 150, pages 108-119.
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Nan Shu, Mengyue Hu, Zhaoli Ling, Peihua Liu, Fan Wang, Ping Xu, Zeyu Zhong, Binbin Sun, Mian Zhang, Feng Li, Qiushi Xie, Xiaodong Liu & Li Liu. (2016) The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1. Scientific Reports 6:1.
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