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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 2
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Molecular Toxicology

The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?

Valerie WalkerDepartment of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK, Correspondence[email protected]
,
Graham A. MillsSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK,
,
Mary E. AndersonDepartment of Chemistry and Biochemistry, Texas Woman’s University, Denton, TX, USA,
,
Brandall L. IngleDepartment of Chemistry, Center for Advanced Scientific Computing and Modeling, University of North Texas, Denton, TX, USA,
,
John M. JacksonNIHR Southampton Biomedical Research Centre, Southampton General Hospital, Southampton, UK, and
,
Charlotte L. MossCentre for Proteomic Research and Biological Sciences, University of Southampton, Southampton, UK
,
Hayley Sharrod-ColeDepartment of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK,
&
Paul J. SkippCentre for Proteomic Research and Biological Sciences, University of Southampton, Southampton, UK
 show all
Pages 164-175 | Received 13 Feb 2016, Accepted 13 Mar 2016, Published online: 18 Apr 2016

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Alan L. Myers, Jitesh D. Kawedia, Richard E. Champlin, Mark A. Kramer, Yago Nieto, Romi Ghose & Borje S. Andersson. (2017) Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opinion on Drug Metabolism & Toxicology 13:9, pages 901-923.
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Petra Mészáros, Sára Kovács, Győző Kulcsár, Melinda Páskuj & Attila Almási. (2022) Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia. International Journal of Molecular Sciences 23:19, pages 11913.
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Doaa Nor Eldin, Hanaa I. Fahim, Heba Y. Ahmed, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab & Osama M. Ahmed. (2022) Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats. Oxidative Medicine and Cellular Longevity 2022, pages 1-21.
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Xiaopeng Cai, Huiqiang Cai, Jing Wang, Qin Yang, Jun Guan, Jingwen Deng & Zhi Chen. (2022) Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options对乙酰氨基酚诱导的肝损伤的分子发病机制及治疗策略. Journal of Zhejiang University-SCIENCE B 23:4, pages 265-285.
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Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 79 137 .
Jiaqi Zhang, Cheng Hu, Xiulong Li, Li Liang, Mingcai Zhang, Bo Chen, Xinhua Liu & Dicheng Yang. (2021) Protective Effect of Dihydrokaempferol on Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway. The American Journal of Chinese Medicine 49:03, pages 705-718.
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Sara S. Jdiaa & Ali K. Abu-Alfa. (2020) The Case | Severe high-anion gap metabolic acidosis. Kidney International 98:6, pages 1625-1626.
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Yuliya Buinitskaya, Roman Gurinovich, Clifford G. Wlodaver & Siarhei Kastsiuchenka. (2020) Centrality of G6PD in COVID-19: The Biochemical Rationale and Clinical Implications. Frontiers in Medicine 7.
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Licong Zhao, Jiaqi Zhang, Cheng Hu, Tao Wang, Juan Lu, Chenqu Wu, Long Chen, Mingming Jin, Guang Ji, Qin Cao & Yuanye Jiang. (2020) Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway. Frontiers in Pharmacology 11.
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Zohreh Sohrabinezhad, Dara Dastan, Sara Soleimani Asl & Amir Nili-Ahmadabadi. (2019) Allium Jesdianum Extract Improve Acetaminophen-Induced Hepatic Failure through Inhibition of Oxidative/Nitrosative Stress . Journal of Pharmacopuncture 22:4, pages 239-247.
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José A.G. Agúndez, Javier Gómez-Tabales, Francisco Ruano & Elena García-Martin. (2018) The potential role of pharmacogenomics and biotransformation in hypersensitivity reactions to paracetamol. Current Opinion in Allergy & Clinical Immunology 18:4, pages 302-309.
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A. Lanot, P. Henri, M. Nowoczyn, M.H. Read, C. Maucorps, M. Sassier & T. Lobbedez. (2018) Acidose à la 5-oxoproline induite par le paracétamol : une cause rare d’acidose métabolique à trou anionique augmenté. La Revue de Médecine Interne 39:2, pages 122-126.
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J. K. Berbee, L. A. Lammers, C. T. P. Krediet, J. C. Fischer & E. M. Kemper. (2017) Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study. European Journal of Clinical Pharmacology 73:11, pages 1459-1465.
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