Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 2
Submit an article Journal homepage
533
Views
13
CrossRef citations to date
0
Altmetric
Molecular Toxicology

The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?

Valerie WalkerDepartment of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK, Correspondence[email protected]
,
Graham A. MillsSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK,
,
Mary E. AndersonDepartment of Chemistry and Biochemistry, Texas Woman’s University, Denton, TX, USA,
,
Brandall L. IngleDepartment of Chemistry, Center for Advanced Scientific Computing and Modeling, University of North Texas, Denton, TX, USA,
,
John M. JacksonNIHR Southampton Biomedical Research Centre, Southampton General Hospital, Southampton, UK, and
,
Charlotte L. MossCentre for Proteomic Research and Biological Sciences, University of Southampton, Southampton, UK
,
Hayley Sharrod-ColeDepartment of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK,
&
Paul J. SkippCentre for Proteomic Research and Biological Sciences, University of Southampton, Southampton, UK
 show all
Pages 164-175 | Received 13 Feb 2016, Accepted 13 Mar 2016, Published online: 18 Apr 2016

Citations (13)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Alan L. Myers, Jitesh D. Kawedia, Richard E. Champlin, Mark A. Kramer, Yago Nieto, Romi Ghose & Borje S. Andersson. (2017) Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opinion on Drug Metabolism & Toxicology 13:9, pages 901-923.
Read now

Articles from other publishers (12)

Petra Mészáros, Sára Kovács, Győző Kulcsár, Melinda Páskuj & Attila Almási. (2022) Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia. International Journal of Molecular Sciences 23:19, pages 11913.
Crossref
Doaa Nor Eldin, Hanaa I. Fahim, Heba Y. Ahmed, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab & Osama M. Ahmed. (2022) Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats. Oxidative Medicine and Cellular Longevity 2022, pages 1-21.
Crossref
Xiaopeng Cai, Huiqiang Cai, Jing Wang, Qin Yang, Jun Guan, Jingwen Deng & Zhi Chen. (2022) Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options对乙酰氨基酚诱导的肝损伤的分子发病机制及治疗策略. Journal of Zhejiang University-SCIENCE B 23:4, pages 265-285.
Crossref
Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 79 137 .
Jiaqi Zhang, Cheng Hu, Xiulong Li, Li Liang, Mingcai Zhang, Bo Chen, Xinhua Liu & Dicheng Yang. (2021) Protective Effect of Dihydrokaempferol on Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway. The American Journal of Chinese Medicine 49:03, pages 705-718.
Crossref
Sara S. Jdiaa & Ali K. Abu-Alfa. (2020) The Case | Severe high-anion gap metabolic acidosis. Kidney International 98:6, pages 1625-1626.
Crossref
Yuliya Buinitskaya, Roman Gurinovich, Clifford G. Wlodaver & Siarhei Kastsiuchenka. (2020) Centrality of G6PD in COVID-19: The Biochemical Rationale and Clinical Implications. Frontiers in Medicine 7.
Crossref
Licong Zhao, Jiaqi Zhang, Cheng Hu, Tao Wang, Juan Lu, Chenqu Wu, Long Chen, Mingming Jin, Guang Ji, Qin Cao & Yuanye Jiang. (2020) Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway. Frontiers in Pharmacology 11.
Crossref
Zohreh Sohrabinezhad, Dara Dastan, Sara Soleimani Asl & Amir Nili-Ahmadabadi. (2019) Allium Jesdianum Extract Improve Acetaminophen-Induced Hepatic Failure through Inhibition of Oxidative/Nitrosative Stress . Journal of Pharmacopuncture 22:4, pages 239-247.
Crossref
José A.G. Agúndez, Javier Gómez-Tabales, Francisco Ruano & Elena García-Martin. (2018) The potential role of pharmacogenomics and biotransformation in hypersensitivity reactions to paracetamol. Current Opinion in Allergy & Clinical Immunology 18:4, pages 302-309.
Crossref
A. Lanot, P. Henri, M. Nowoczyn, M.H. Read, C. Maucorps, M. Sassier & T. Lobbedez. (2018) Acidose à la 5-oxoproline induite par le paracétamol : une cause rare d’acidose métabolique à trou anionique augmenté. La Revue de Médecine Interne 39:2, pages 122-126.
Crossref
J. K. Berbee, L. A. Lammers, C. T. P. Krediet, J. C. Fischer & E. M. Kemper. (2017) Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study. European Journal of Clinical Pharmacology 73:11, pages 1459-1465.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.