The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?

Valerie WalkerDepartment of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK, Correspondence[email protected]

Graham A. MillsSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK,

Mary E. AndersonDepartment of Chemistry and Biochemistry, Texas Woman’s University, Denton, TX, USA,

Brandall L. IngleDepartment of Chemistry, Center for Advanced Scientific Computing and Modeling, University of North Texas, Denton, TX, USA,

John M. JacksonNIHR Southampton Biomedical Research Centre, Southampton General Hospital, Southampton, UK, and

Charlotte L. MossCentre for Proteomic Research and Biological Sciences, University of Southampton, Southampton, UK

Hayley Sharrod-ColeDepartment of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton, UK,

Paul J. SkippCentre for Proteomic Research and Biological Sciences, University of Southampton, Southampton, UK

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The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?

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The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?

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