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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 4-5
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Research Article

Alkaloid N-Oxides

Pages 419-447 | Received 01 Oct 1971, Published online: 14 Oct 2008

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Read on this site (4)

Peter P. Fu, Qingsu Xia, Ge Lin & Ming W. Chou. (2004) Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms. Drug Metabolism Reviews 36:1, pages 1-55.
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P. P. Fu, M. W. Chou, Q. Xia, Y.-C. Yang, J. Yan, D. R. Doerge & P. C. Chan. (2001) GENOTOXIC PYRROLIZIDINE ALKALOIDS AND PYRROLIZIDINE ALKALOID N-OXIDES—MECHANISMS LEADING TO DNA ADDUCT FORMATION AND TUMORIGENICITY. Journal of Environmental Science and Health, Part C 19:2, pages 353-385.
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K. Takekawa, K. Sugihara, S. Kitamura & S. Ohta. (2001) Enzymatic and non-enzymatic reduction of brucine N -oxide by aldehyde oxidase and catalase. Xenobiotica 31:11, pages 769-782.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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Articles from other publishers (24)

Gopal Chandru Senadi, Ji-Qi Wang, Babasaheb Sopan Gore & Jeh-Jeng Wang. (2017) Bis(dibenzylideneacetone)palladium(0)/ tert- Butyl Nitrite- Catalyzed Cyclization of o -Alkynylanilines with tert- Butyl Nitrite: Synthesis and Applications of Indazole 2-Oxides . Advanced Synthesis & Catalysis 359:16, pages 2747-2753.
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J D PhillipsonS S HandaJ W Gorrod. (1976) Metabolic TV-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations. Journal of Pharmacy and Pharmacology 28:9, pages 687-691.
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Trong D. Tran, Ngoc B. Pham, Gregory Fechner & Ronald J. Quinn. (2010) Chemical investigation of drug-like compounds from the Australian tree, Neolitsea dealbata. Bioorganic & Medicinal Chemistry Letters 20:19, pages 5859-5863.
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J.P. Silva-Neto, R.A. Barreto, B.P.S. Pitanga, C.S. Souza, V.D. Silva, A.R. Silva, E.S. Velozo, S.D. Cunha, M.J.M. Batatinha, M. Tardy, C.S.O. Ribeiro, M.F.D. Costa, R.S. El-Bach?S.L. Costa. (2010) Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells. Toxicon 55:1, pages 105-117.
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Ming W. Chou, Yu-Ping Wang, Jian Yan, Ya-Chen Yang, Richard D. Beger, Lee D. Williams, Daniel R. Doerge & Peter P. Fu. (2003) Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine. Toxicology Letters 145:3, pages 239-247.
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Elizabeth A. Gerson & Rick G. Kelsey. (1999) Foliar storage and extraction methods for quantitative analysis of piperidine alkaloids from ponderosa pine (Pinus ponderosa). Phytochemical Analysis 10:6, pages 322-327.
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J.David Phillipson. (1995) A matter of some sensitivity. Phytochemistry 38:6, pages 1319-1343.
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T. Gul Altuntas & John W. Gorrod. (1995) Factors Involved in the N-Oxidation of Isomeric Aromatic Diazines by Microsomal Preparations. Drug Metabolism and Drug Interactions 12:2.
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Thomas Hartmann & Ludger Witte. 1995. 155 233 .
Adelheid Ehmke, Kirsten von Borstel & Thomas Hartmann. (1988) Alkaloid N-oxides as transport and vacuolar storage compounds of pyrrolizidine alkaloids in Senecio vulgaris L. Planta 176:1, pages 83-90.
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Thomas Hartmann. 1988. Phytochemicals in Plant Cell Cultures. Phytochemicals in Plant Cell Cultures 277 288 .
Gerd Toppel, Ludger Witte & Thomas Hartmann. (1988) N-oxidation and degradation of pyrrolizidine alkaloids during germination of Crotalaria scassellatii. Phytochemistry 27:12, pages 3757-3760.
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Kazuki Saito, Satoshi Takamatsu, Shigeru Ohmiya, Hirotaka Otomasu, Masaho Yasuda, Yoshihiro Kano & Isamu Murakoshi. (1988) Lupin alkaloids from the seeds of Thermopsis lupinoides. Phytochemistry 27:11, pages 3715-3716.
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Thomas Hartmann & Gerd Toppel. (1987) Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry 26:6, pages 1639-1643.
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Kirsten von Borstel & Thomas Hartmann. (1986) Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants. Plant Cell Reports 5:1, pages 39-42.
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Thomas Hartmann & Michael Zimmer. (1986) Organ-specific Distribution and Accumulation of Pyrrolizidine Alkaloids during the Life History of two Annual Senecio Species. Journal of Plant Physiology 122:1, pages 67-80.
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S. Pummangura, Y.A.H. Mohamed, C.-J. Chang & J.L. McLaughlin. (1982) Two simple tetrahydroisoquinoline alkaloid N-oxides from cacti. Phytochemistry 21:9, pages 2375-2377.
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H.L. Holland. 1981. 323 400 .
J. Pottier, M. Busigny & J. P. Raynaud. (1979) Biotransformations of glafenine in the rat and in man. European Journal of Drug Metabolism and Pharmacokinetics 4:2, pages 109-115.
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D. Dwuma-Badu, T.U. Okarter, A.N. Tackie, J.A. Lopez, D.J. Slatkin, J.E. Knapp & P.L. SchiffJr.Jr.. (1977) Constituents of West African Medicinal Plants XIX: Funiferine N-Oxide, a New Alkaloid from Tiliacora funifera (Menispermaceae). Journal of Pharmaceutical Sciences 66:9, pages 1242-1244.
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J.David Phillipson & S.S. Handa. (1975) Nicotine N-oxides. Phytochemistry 14:12, pages 2683-2690.
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J.David Phillipson & S.S. Handa. (1975) N-oxides of hyoscyamine and hyoscine in the solanaceae. Phytochemistry 14:4, pages 999-1003.
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John David Phillipson & Sarah Rose Hemingway. (1973) Indole and oxindole alkaloids from Uncaria bernaysia. Phytochemistry 12:6, pages 1481-1487.
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L. Merlini, G. Nasini & J.D. Phillipson. (1972) Structure and synthesis of new natural heteroyohimbine N-oxides. Tetrahedron 28:24, pages 5971-5975.
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