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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 4-5
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Research Article

The Occurrence and Analysis of Pyrrolizidine Alkaloid N-Oxides

Pages 451-453 | Received 01 Oct 1971, Published online: 14 Oct 2008

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Read on this site (2)

Peter P. Fu, Qingsu Xia, Ge Lin & Ming W. Chou. (2004) Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms. Drug Metabolism Reviews 36:1, pages 1-55.
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P. P. Fu, M. W. Chou, Q. Xia, Y.-C. Yang, J. Yan, D. R. Doerge & P. C. Chan. (2001) GENOTOXIC PYRROLIZIDINE ALKALOIDS AND PYRROLIZIDINE ALKALOID N-OXIDES—MECHANISMS LEADING TO DNA ADDUCT FORMATION AND TUMORIGENICITY. Journal of Environmental Science and Health, Part C 19:2, pages 353-385.
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Articles from other publishers (16)

Mengbi Yang, Jiang Ma, Jianqing Ruan, Chunyuan Zhang, Yang Ye, Peter Pi-Cheng Fu & Ge Lin. (2020) Absorption difference between hepatotoxic pyrrolizidine alkaloids and their N-oxides – Mechanism and its potential toxic impact. Journal of Ethnopharmacology 249, pages 112421.
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Mengbi Yang, Jiang Ma, Jianqing Ruan, Yang Ye, Peter Pi-Cheng Fu & Ge Lin. (2019) Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids. Archives of Toxicology 93:8, pages 2197-2209.
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Tiziana Nardin, Edi Piasentier, Chiara Barnaba & Roberto Larcher. (2018) Alkaloid profiling of herbal drugs using high resolution mass spectrometry. Drug Testing and Analysis 10:3, pages 423-448.
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Mengbi Yang, Jianqing Ruan, Hong Gao, Na Li, Jiang Ma, Junyi Xue, Yang Ye, Peter Pi-Cheng Fu, Jiyao Wang & Ge Lin. (2017) First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans. Archives of Toxicology 91:12, pages 3913-3925.
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Caroline T. Griffin, Aisling Sheehan, Martin Danaher & Ambrose Furey. 2017. Analysis of Food Toxins and Toxicants. Analysis of Food Toxins and Toxicants 267 318 .
Tiziana Nardin, Edi Piasentier, Chiara Barnaba & Roberto Larcher. (2016) Targeted and untargeted profiling of alkaloids in herbal extracts using online solid-phase extraction and high-resolution mass spectrometry (Q-Orbitrap). Journal of Mass Spectrometry 51:9, pages 729-741.
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Bharathi Avula, Satyanarayanaraju Sagi, Yan-Hong Wang, Jerry Zweigenbaum, Mei Wang & Ikhlas A. Khan. (2015) Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. Food Chemistry 178, pages 136-148.
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J.P. Silva-Neto, R.A. Barreto, B.P.S. Pitanga, C.S. Souza, V.D. Silva, A.R. Silva, E.S. Velozo, S.D. Cunha, M.J.M. Batatinha, M. Tardy, C.S.O. Ribeiro, M.F.D. Costa, R.S. El-Bach?S.L. Costa. (2010) Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells. Toxicon 55:1, pages 105-117.
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Ming W. Chou, Yu-Ping Wang, Jian Yan, Ya-Chen Yang, Richard D. Beger, Lee D. Williams, Daniel R. Doerge & Peter P. Fu. (2003) Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine. Toxicology Letters 145:3, pages 239-247.
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Mario Chojkier. (2003) Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. Journal of Hepatology 39:3, pages 437-446.
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Thomas Hartmann, Claudine Theuring, J?rgen Schmidt, Martine Rahier & Jacques M Pasteels. (1999) Biochemical strategy of sequestration of pyrrolizidine alkaloids by adults and larvae of chrysomelid leaf beetles. Journal of Insect Physiology 45:12, pages 1085-1095.
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Rainer Lindigkeit, Andreas Biller, Markus Buch, Hans‐Martin Schiebel, Michael Boppré & Thomas Hartmann. (2004) The two Faces of Pyrrolizidine Alkaloids: the Role of the Tertiary Amine and its N ‐Oxide in Chemical Defense of Insects with Acquired Plant Alkaloids . European Journal of Biochemistry 245:3, pages 626-636.
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Thomas Hartmann & Ludger Witte. 1995. 155 233 .
Thomas Hartmann. (1994) Pyrrolizidine alkaloids between plants and insects: A new chapter of an old story. Chemoecology 5-6:3-4, pages 139-146.
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Adelheid Ehmke, Kirsten von Borstel & Thomas Hartmann. (1988) Alkaloid N-oxides as transport and vacuolar storage compounds of pyrrolizidine alkaloids in Senecio vulgaris L. Planta 176:1, pages 83-90.
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Gerd Toppel, Ludger Witte & Thomas Hartmann. (1988) N-oxidation and degradation of pyrrolizidine alkaloids during germination of Crotalaria scassellatii. Phytochemistry 27:12, pages 3757-3760.
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