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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 4-5
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Research Article

Hepatotoxic Effects due to Pyrrolizidine Alkaloid N-Oxides

Pages 563-565 | Received 01 Oct 1971, Published online: 14 Oct 2008

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Read on this site (6)

Christoph Gottschalk, Aiko Huckauf, Arne Dübecke, Florian Kaltner, Matthias Zimmermann, Ines Rahaus & Till Beuerle. (2018) Uncertainties in the determination of pyrrolizidine alkaloid levels in naturally contaminated honeys and comparison of results obtained by different analytical approaches. Food Additives & Contaminants: Part A 35:7, pages 1366-1383.
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A. Eller & R. Chizzola. (2016) Seasonal variability in pyrrolizidine alkaloids in Senecio inaequidens from the Val Venosta (Northern Italy). Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology 150:6, pages 1306-1312.
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L.A.P. Hoogenboom, P.P.J. Mulder, M.J. Zeilmaker, H.J. van den Top, G.J. Remmelink, E.F.A. Brandon, M. Klijnstra, G.A.L. Meijer, R. Schothorst & H.P. Van Egmond. (2011) Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows. Food Additives & Contaminants: Part A 28:3, pages 359-372.
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Peter P. Fu, Qingsu Xia, Ge Lin & Ming W. Chou. (2004) Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms. Drug Metabolism Reviews 36:1, pages 1-55.
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P. P. Fu, M. W. Chou, Q. Xia, Y.-C. Yang, J. Yan, D. R. Doerge & P. C. Chan. (2001) GENOTOXIC PYRROLIZIDINE ALKALOIDS AND PYRROLIZIDINE ALKALOID N-OXIDES—MECHANISMS LEADING TO DNA ADDUCT FORMATION AND TUMORIGENICITY. Journal of Environmental Science and Health, Part C 19:2, pages 353-385.
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Iwao Hirono & Paul Grasso. (1981) Natural Carcinogenic Products of Plant Origin. CRC Critical Reviews in Toxicology 8:3, pages 235-277.
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Articles from other publishers (39)

Adebayo J. Akinboye, Kiyun Kim, Seyun Choi, Inho Yang & Joon-Goo Lee. (2023) Alkaloids in food: a review of toxicity, analytical methods, occurrence and risk assessments. Food Science and Biotechnology 32:9, pages 1133-1158.
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Frances Widjaja, Liang Zheng, Sebastiaan Wesseling & Ivonne M. C. M. Rietjens. (2023) Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides. Frontiers in Pharmacology 14.
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Frances Widjaja, Yasser Alhejji, Jamyang Yangchen, Sebastiaan Wesseling & Ivonne M. C. M. Rietjens. (2023) Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels. Molecular Nutrition & Food Research 67:4.
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Lin Zhu, Junyi Xue, Yisheng He, Qingsu Xia, Peter P. Fu & Ge Lin. (2022) Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid. Toxins 14:6, pages 377.
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Frances Widjaja, Yasser Alhejji & Ivonne M. C. M. Rietjens. (2021) The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides. Planta Medica 88:02, pages 130-143.
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Frances Widjaja, Sebastiaan Wesseling & Ivonne M. C. M. Rietjens. (2021) Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent. Archives of Toxicology 96:1, pages 135-151.
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Yisheng He, Lin Zhu, Jiang Ma & Ge Lin. (2021) Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids. Archives of Toxicology 95:6, pages 1917-1942.
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Mengbi Yang, Jiang Ma, Jianqing Ruan, Yang Ye, Peter Pi-Cheng Fu & Ge Lin. (2019) Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids. Archives of Toxicology 93:8, pages 2197-2209.
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Sebastian Schramm, Nikolai Köhler & Wilfried Rozhon. (2019) Pyrrolizidine Alkaloids: Biosynthesis, Biological Activities and Occurrence in Crop Plants. Molecules 24:3, pages 498.
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Mengbi Yang, Jianqing Ruan, Hong Gao, Na Li, Jiang Ma, Junyi Xue, Yang Ye, Peter Pi-Cheng Fu, Jiyao Wang & Ge Lin. (2017) First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans. Archives of Toxicology 91:12, pages 3913-3925.
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Peter P. Fu. (2016) Pyrrolizidine Alkaloids: Metabolic Activation Pathways Leading to Liver Tumor Initiation. Chemical Research in Toxicology 30:1, pages 81-93.
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Karl-Heinz Merz & Dieter Schrenk. (2016) Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines. Toxicology Letters 263, pages 44-57.
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A.N. Gould, C.B. Penny, C.C. Patel & G.P. Candy. (2015) Enhanced cutaneous wound healing by Senecio serratuloides ( Asteraceae/Compositae ) in a pig model. South African Journal of Botany 100, pages 63-68.
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