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Xenobiotica
the fate of foreign compounds in biological systems
Volume 4, 1974 - Issue 12
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Research Article

Metabolism of the Hydroxyethylrutosides III. The Fate of Orally Administered Hydroxyethylrutosides in Laboratory Animals; Metabolism by Rat Intestinal Microflora in vitro

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Pages 743-754 | Received 20 May 1974, Published online: 22 Sep 2008

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R. Perego, P. Beccaglia, M. Angelini, P. Villa & D. Cova. (1993) Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver. Xenobiotica 23:12, pages 1345-1352.
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I. C. Shaw & L. A. Griffiths. (1980) Identification of the major biliary metabolite of (+)-catechin in the rat. Xenobiotica 10:12, pages 905-911.
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A. M. Hackett, I. Marsh, A. Barrow & L. A. Griffiths. (1979) The biliary excretion of flavanones in the rat. Xenobiotica 9:8, pages 491-501.
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G.C. Silva, F.C. Braga, M.P. Lima, J.L. Pesquero, V.S. Lemos & S.F. Cortes. (2011) Hancornia speciosa Gomes induces hypotensive effect through inhibition of ACE and increase on NO. Journal of Ethnopharmacology 137:1, pages 709-713.
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Markward Marshall & Dieter LoewMonika Schäfer-Korting, Markward Marshall & Dieter Loew. 2003. Venenerkrankungen. Venenerkrankungen 149 207 .
M.A.I Abou El Hassan, M.A Kedde, A Bast & W.J.F van der Vijgh. (2001) Determination of monohydroxyethylrutoside in heart tissue by high-performance liquid chromatography with electrochemical detection. Journal of Chromatography B: Biomedical Sciences and Applications 757:1, pages 191-196.
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M.A.I. Abou El Hassan, M.A. Kedde, A. Bast & W.J.F. van der Vijgh. (2001) High-performance liquid chromatography with electrochemical detection for the determination of 7-monohydroxyethylrutoside in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 752:1, pages 115-121.
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H. Schneider, R. Simmering, L. Hartmann, H. Pforte & M. Blaut. (2000) Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. Journal of Applied Microbiology 89:6, pages 1027-1037.
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Irmgard Merfort & Irmgard Merfort. (2006) Aktueller Kenntnisstand zum Metabolismus von Flavonoiden I. Resorption und Metabolismus von Flavonolen. Pharmazie in unserer Zeit 27:2, pages 58-65.
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Brian L. Goodwin, Colin R.J. Ruthven & Merton Sandler. (1994) Gut flora and the origin of some urinary aromatic phenolic compounds. Biochemical Pharmacology 47:12, pages 2294-2297.
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Margitta Albinus, Gudrun Amschler, Uwe Amschler, Erwin von Angerer, Wolfgang Barthel, Andrea Bauer, Kurt Bauer, Jürgen Beckmann, Winfried Beil, Jürgen Beitz, Petra Berscht, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bracher, Helmut Bräunlich, Kerstin Brinkmann, Franz von Bruchhausen, Kay Brune, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Siegfried Ebel, Kurt Eger, Peter Emig, Thomas Erker, Maria S. Fernandez-Alfonso, August Wilhelm Frahm, Margarete Frahm, Klaus-Jürgen Freundt, Detlef Geffken, Ulrich Geis, Erika Glusa, Berthold Göber, Jochen Gödicke, Margarete Goppelt-Strübe, Wilhelm Gössling, Annette Graul, Sibylle Greiner, Adolf Grisk, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Axel Haberkorn, Eberhard Hackenthal, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Andreas Hensel, Sibylle Hoedt-Schmidt, Hermann Hoffmann, Ute Hoffmann-Schollmayer, Ulrike Holzgrabe, Martin Hug, Wolfgang Ibrom, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Nasser Khudeir, Werner Kiefer, Doris Kleinsorge, Christoph Klett, Stephanie Klett, Martin Klingmüller, H.-P. Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, Gottfried Kreutz, Reinhard Kroker, Dorothea Landsiedel-Maier, Jochen Lehmann, Marion Sylvia Lehner, Stefan Leiner, Hans Löwe, Johannes Mann, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Hans-Jürgen Mest, Frank Peter Meyer, J. Mollière, Rudolf Morgenstern, Wolfgang Morick, Joachim Mössner, Christa Müller, Daniel Müller, Klaus Müller, Walter Müller, Alexander Mülsch, Tilo Netzer, Michael Neugebauer, Ulf Niemeyer, Peter Nuhn, Bernd Nürnberg, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Martina Pickert, Andreas Pies, Klaus Pietrzik, Detlef Preiss, Helmut Priewer, Olaf Queckenberg, Eberhard Reimann, Jörg Remien, Rainer Rettig, Andreas Reymann, Joachim Richter, Hans Rommelspacher, Ulrich Rose, Gerhard Rücker, Klaus Schaefer, Helmut Schlager, Werner Schleicher, Hildegard Schleinitz, Wolfgang Schlichter, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Helmut Schwilden, Monika Serke, Gisela Skopp, Marcus Spohn, Ralf Stahlmann, Johannes-Peter Stasch, Christian Steffen, Jürgen Steinmeyer, Karl-Heinz Surborg, Ulf Sürig, Istvan Szelenyi, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Franz-Josef Volk, Heinz Walther, Horst Weber, Judith Wede, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Hilke Winterhoff, Reinhold Wintersteiger, Frauke Woltmann, Diaa Youssef & A. Ziegler. 1994. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 765 1129 .
D. Marzin, H.Vo Phi, Ph. Olivier & J. Sauzieres. (1987) Study of mutagenic activity of troxerutin, a flavonoid derivative. Toxicology Letters 35:2-3, pages 297-305.
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A.K. Mallett, I.R. Rowland, C.A. Bearne, R. Purchase & S.D. Gangolli. (1985) Metabolic adaptation of rat faecal microflora to cyclamate in vitro. Food and Chemical Toxicology 23:12, pages 1029-1034.
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Shigeo Baba, Takashi Furuta, Minoru Fujioka & Tsuyoshi Goromaru. (1983) Studies on Drug Metabolism by Use of Isotopes XXVII: Urinary Metabolites of Rutin in Rats and the Role of Intestinal Microflora in the Metabolism of Rutin. Journal of Pharmaceutical Sciences 72:10, pages 1155-1158.
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A.G. Renwick. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 3 28 .
Leslie A. Griffiths. 1982. The Flavonoids. The Flavonoids 681 718 .
Takashi Furuta, Masanobu Horie, Shigeo Baba & Hisashi Nakagawa. (1981) Studies on drug metabolism by use of isotopes XXVI: Determination of urinary metabolites of rutin in humans. Journal of Pharmaceutical Sciences 70:7, pages 780-782.
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A. M. Hackett & L. A. Griffiths. (1979) The metabolism and excretion of 7-mono-0-(β-hydroxyethyl) rutoside in the dog. European Journal of Drug Metabolism and Pharmacokinetics 4:4, pages 207-212.
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R.A. PRINS. 1978. Nutrition and Drug Interrelations. Nutrition and Drug Interrelations 189 251 .
Gertrud Mehringer. 1978. O-(β-Hydroxyethyl)-rutoside—experimentelle und klinische Ergebnisse. O-(β-Hydroxyethyl)-rutoside—experimentelle und klinische Ergebnisse 199 224 .
A. M. Hackett & L. A. Griffiths. (1977) Enterohepatic cycling of O-(β-hydroxyethyl) rutosides and their biliary metabolites in the rat. Experientia 33:2, pages 161-163.
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