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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 12
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Research Article

Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver

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Pages 1345-1352 | Received 13 Aug 1993, Published online: 22 Sep 2008
 

Abstract

1. The kinetics and metabolism of diosmin and diosmetin were investigated in the isolated perfused rat liver in order to assess the role of the liver.

2. Diosmetin and especially diosmin disappeared quickly from the perfusion medium.

3. Both flavonoids were rapidly metabolized and diosmetin was partly excreted in bile as the glucuronide and sulphate and diosmin was partly excreted in bile as such and as the glucuronide conjugate.

4. Diosmin and diosmetin did not appear to affect various parameters of liver function.

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