Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver

R. Perego CNR (National Research Council), Center of Cytopharmacology, Department of Pharmacology, via Vanvitelli 32, I-20129, Milan, Italy

P. Beccaglia CNR (National Research Council), Center of Cytopharmacology, Department of Pharmacology, via Vanvitelli 32, I-20129, Milan, Italy

M. Angelini Experimental Liver Toxicology Unit, Istituto di Ricerche Farmacologiche, Mario Negri, via Eritrea 62, I-20157, Milan, Italy

P. Villa CNR (National Research Council), Center of Cytopharmacology, Department of Pharmacology, via Vanvitelli 32, I-20129, Milan, Italy

D. Cova CNR (National Research Council), Center of Cytopharmacology, Department of Pharmacology, via Vanvitelli 32, I-20129, Milan, Italy

Abstract

1. The kinetics and metabolism of diosmin and diosmetin were investigated in the isolated perfused rat liver in order to assess the role of the liver.

2. Diosmetin and especially diosmin disappeared quickly from the perfusion medium.

3. Both flavonoids were rapidly metabolized and diosmetin was partly excreted in bile as the glucuronide and sulphate and diosmin was partly excreted in bile as such and as the glucuronide conjugate.

4. Diosmin and diosmetin did not appear to affect various parameters of liver function.

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Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver

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Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver

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