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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 4
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Research Article

The Fate of Metronidazole and its Implications in Chemotherapy

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Pages 223-235 | Received 15 Jun 1974, Published online: 22 Sep 2008

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Varsha Moudgal & Jack D. Sobel. (2012) Clostridium difficile Colitis: A Review. Hospital Practice 40:1, pages 139-148.
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M. Steinbakk, E. Lingaas, B. Carlstedt-Duke, T. Høverstad, A.-C. Midtvedt, K. E. Norin & T. Midtvedt. (1992) Faecal Concentration of Ten Antibiotics and Influence on Some Microflora-Associated Characteristics (MACs). Microbial Ecology in Health and Disease 5:5, pages 269-276.
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W. R. Rush, O. F. Alexander, D. J. Hall, R. J. Dow, L. Tokes, L. Kurz & D. J. M. Graham. (1990) The metabolism of nafimidone hydrochloride in the dog, primates and man. Xenobiotica 20:1, pages 123-132.
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David P. Benziger & Jerome Edelson. (1983) Absorption from the Vagina. Drug Metabolism Reviews 14:2, pages 137-168.
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Mitsuo Nakao & Yasushi Takeda. (1983) Distribution, excretion, and metabolism of nitro‐p‐phenylenediamine in rats. Journal of Toxicology and Environmental Health 11:1, pages 93-100.
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H. S. Buttar. (1982) Fate of metronidazole following intra vaginal and intravenous administration to rabbits. Journal of Toxicology and Environmental Health 9:2, pages 305-316.
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V. Facchini & L. A. Griffiths. (1980) The metabolic fate of nitromide in the rat. I. Metabolism and excretion. Xenobiotica 10:4, pages 289-297.
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D. E. Schwartz, J.-C. Jordan, W. Vetter & G. Oesterhelt. (1979) Metabolic Studies of Ornidazole in the Rat, in the Dog and in Man. Xenobiotica 9:9, pages 571-581.
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Articles from other publishers (48)

Heidi Cecilie Villmones, Adrian Halland, Tore Stenstad, Elling Ulvestad, Harald Weedon-Fekjær & Øyvind Kommedal. (2021) The cultivable microbiota of the human distal ileum. Clinical Microbiology and Infection 27:6, pages 912.e7-912.e13.
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Simon A Dingsdag & Neil Hunter. (2018) Metronidazole: an update on metabolism, structure–cytotoxicity and resistance mechanisms. Journal of Antimicrobial Chemotherapy 73:2, pages 265-279.
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Yuanhu Pan, Jiliang Yi, Bo Zhou, Shuyu Xie, Dongmei Chen, Yanfei Tao, Wei Qu, Zhenli Liu, Lingli Huang & Zonghui Yuan. (2017) Disposition and Residue Depletion of Metronidazole in Pigs and Broilers. Scientific Reports 7:1.
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Jiangbo Du. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
C F George & Beryl S Gruchy. (1979) Elimination of drugs by active intestinal transport. Journal of Pharmacy and Pharmacology 31:1, pages 643-644.
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H S Buttar, W H Siddiqui & J H Moffatt. (1979) The disposition of [14C]metronidazole in rats following vaginal and oral administration. Journal of Pharmacy and Pharmacology 31:1, pages 542-544.
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Thomas A. Brown, Timothy R. Pasquale, John C. Fondran, Hector H. Bonilla, Michael J. Cullado, Frederick A. Slezak & Joseph P. Myers. (2009) Clostridium difficile-Associated Proctitis of the Rectal Stump. Infectious Diseases in Clinical Practice 17:1, pages 71-74.
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Richard J. Farrell, Lorraine Kyne & Ciarán P. Kelly. 2005. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 823 844 .
Richard J. Farrell, Lorraine Kyne & Ciarán P. Kelly. 2003. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 823 844 .
Lorraine Kyne, Richard J. Farrell & Ciarán P. Kelly. (2001) Clostridium difficile. Gastroenterology Clinics of North America 30:3, pages 753-777.
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D. N. Gerding. 2000. Clostridium difficile. Clostridium difficile 127 139 .
. 1999. Advances in Heterocyclic Chemistry Volume 74. Advances in Heterocyclic Chemistry Volume 74 223 240 .
Jerzy Suwiński & Wojciech Szczepankiewicz. (1996) Synthesis of 2-methyl-4(5)-nitro[15N1(3)]imidazole from 2-methyl-4(5)-nitroimidazole. Journal of Labelled Compounds and Radiopharmaceuticals 38:4, pages 395-401.
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Dale N. Gerding, Stuart Johnson, Lance R. Peterson, Maury E. Mulligan & Joseph SilvaJr.Jr.. (1995) Clostridium difficile-Associated Diarrhea and Colitis. Infection Control and Hospital Epidemiology 16:8, pages 459-477.
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David J. Lythgoe & Christopher A. Ramsden. 1994. Advances in Heterocyclic Chemistry Volume 61. Advances in Heterocyclic Chemistry Volume 61 1 58 .
B.M. Honigberg & Donald E. Burgess. 1994. Parasitic Protozoa. Parasitic Protozoa 1 109 .
M.Abu Shamat. (1993) The role of the gastrointestinal microflora in the metabolism of drugs. International Journal of Pharmaceutics 97:1-3, pages 1-13.
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Stuart Johnson, Scott R. Homann, Kristine M. Bettin, Judith N. Quick, Connie R. Clabots, Lance R. Peterson & Dale N. Gerding. (1992) Treatment of Asymptomatic Clostridium difficile Carriers (Fecal Excretors) with Vancomycin or Metronidazole . Annals of Internal Medicine 117:4, pages 297-302.
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Steffen Loft. (1990) Metronidazole and Antipyrine as Probes for the Study of Foreign Compound Metabolism. Pharmacology & Toxicology 66, pages 1-31.
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Steffen Loft & Henrik Enohusen Poulsen. (1989) Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Biochemical Pharmacology 38:7, pages 1125-1136.
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Okponanabofa Eradiri, Fakhreddin Jamali & Alan B. R. Thomson. (1987) Steady-state pharmacokinetics of metronidazole in Crohn's disease. Biopharmaceutics & Drug Disposition 8:3, pages 249-259.
Crossref
A. Barrow, S. R. Burford, T. J. Forrest, A. J. Hawkins, D. A. Rose, P. M. Stevens, C. W. Vose & C. M. Walls. (1987) Studies on the disposition of a 5-nitroimidazole in laboratory animals. European Journal of Drug Metabolism and Pharmacokinetics 12:2, pages 85-90.
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P. T. Männistö, O. Saijonmaa & H. Haataja. (2009) Effect of Enzyme Induction and Inhibition on the Fate of Metronidazole and Tinidazole in the Rat. Pharmacology & Toxicology 60:1, pages 24-28.
Crossref
R P Bolton & M A Culshaw. (1986) Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile.. Gut 27:10, pages 1169-1172.
Crossref
B.H. Raseroka & W.E. Ormerod. (1986) The trypanocidal effect of drugs in different parts of the brain. Transactions of the Royal Society of Tropical Medicine and Hygiene 80:4, pages 634-641.
Crossref
S N Moreno & R Docampo. (1985) Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis.. Environmental Health Perspectives 64, pages 199-208.
Crossref
Helen Allars, Malcolm D. Coleman & Raymond S. Norton. (2010) 1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver. European Journal of Drug Metabolism and Pharmacokinetics 10:3, pages 253-260.
Crossref
J. Lindhe, B. Liljenberg, B. Adielson & I. Börjesson. (2005) Use of metronidazole as a probe in the study of human periodontal disease. Journal of Clinical Periodontology 10:1, pages 100-112.
Crossref
Moises Agosin. (1983) The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 75:2, pages 311-315.
Crossref
M. D. Nair & K. Nagarajan. 1983. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 163 252 .
T K Daneshmend, M Homeida, C M Kaye, A A Elamin & C J Roberts. (1982) Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis.. Gut 23:10, pages 807-813.
Crossref
M.J. Cho, R.R. Kurtz, C. Lewis, S.M. Machkovech & D.J. Houser. (1982) Metronidazole Phosphate—A Water-Soluble Prodrug for Parenteral Solutions of Metronidazole. Journal of Pharmaceutical Sciences 71:4, pages 410-414.
Crossref
Paul Workman. 1982. Advanced Topics on Radiosensitizers of Hypoxic Cells. Advanced Topics on Radiosensitizers of Hypoxic Cells 143 163 .
D. E. Schwartz & W. Hofheinz. 1982. Nitroimidazoles. Nitroimidazoles 91 104 .
Francis P. Tally & C. Edmond Sullivan. (2012) Metronidazole: In Vitro Activity, Pharmacology and Efficacy in Anaerobic Bacterial Infections. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 1:1, pages 28-38.
Crossref
A Krook, B Lindstrom, J Kjellander, G Jarnerot & L Bodin. (1981) Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals.. Journal of Clinical Pathology 34:6, pages 645-650.
Crossref
CAROL A. NEFF‐DAVIS, LLOYD E. DAVIS & EDWARD L. GILLETTE. (2008) Metronidazole: a method for its determination in biological fluids and its disposition kinetics in the dog. Journal of Veterinary Pharmacology and Therapeutics 4:2, pages 121-127.
Crossref
C.E. Voogd. (1981) On the mutagenicity of nitroimidazoles. Mutation Research/Reviews in Genetic Toxicology 86:3, pages 243-277.
Crossref
A. Li Wan Po & W. J. Irwin. (1980) HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUES AND APPLICATIONS. Journal of Clinical Pharmacy and Therapeutics 5:2, pages 107-144.
Crossref
MichaelJ Balsdon, GeorgeE Taylor, Rosalind Maskell & Linda Pead. (1980) CORYNEBACTERIUM VAGINALE AND VAGINITIS: A CONTROLLED TRIAL OF TREATMENT. The Lancet 315:8167, pages 501-504.
Crossref
Ronald L. Koch, Ewan J.T. Chrystal, Bernard B. BeaulieuJr.Jr. & Peter Goldman. (1979) Acetamide—a metabolite of metronidazole formed by the intestinal flora. Biochemical Pharmacology 28:24, pages 3611-3615.
Crossref
L. Heijl & J. Lindhe. (2005) The effect of metronidazole on the development of plaque and gingivitis in the beagle dog. Journal of Clinical Periodontology 6:4, pages 197-209.
Crossref
Bo Lambert, Annette Lindblad & Ulrik Ringborg. (1979) Absence of genotoxic effects of metronidazole and two of its urinary metabolites on human lymphocytes in vitro. Mutation Research/Genetic Toxicology 67:3, pages 281-287.
Crossref
C.E. Voogd, J.J. Van Der Stel & J.J.J.A.A. Jacobs. (1979) The mutagenic action of nitroimidazoles. Mutation Research/Genetic Toxicology 66:3, pages 207-221.
Crossref
Z. Brener. (1979) Present status of chemotheraphy and chemoprophylaxis of human trypanosomiasis in the Western Hemisphere. Pharmacology & Therapeutics 7:1, pages 71-90.
Crossref
Nicholas F. Larusso, Donald G. Lindmark & Miklós Müller. (1978) Biliary and renal excretion, hepatic metabolism, and hepatic subcellular distribution of metronidazole in the rat. Biochemical Pharmacology 27:18, pages 2247-2254.
Crossref
Michael N. Eakins, Peter J. Conroy, Andrew J. Searle, Trevor F. Slater & Robin L. Willson. (1976) Metronidazole (flagyl), a radiosensitiser of possible clinical use in cancer chemotherapy: Some biochemical and pharmacological considerations. Biochemical Pharmacology 25:10, pages 1151-1156.
Crossref
Lorraine L. Wearley & Gaylord D. Anthony. 1976. 327 344 .

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