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Original Articles

Distribution, excretion, and metabolism of nitro‐p‐phenylenediamine in rats

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Pages 93-100 | Received 13 Jul 1982, Accepted 30 Aug 1982, Published online: 19 Oct 2009
 

Abstract

The distribution, excretion, and metabolism of nitro‐p‐phenylenediamine, a constituent of hair dye, was studied after administration of [14C/nitro‐p‐phenylenediamine (2.6 mg/30 μCi/kg) to male rats. After intraperitoneal administration, 37.4% of the radioactivity administered was excreted in the urine and 54.3% in the feces within 24 h. After intravenous administration, 42.2% of the radioactivity was excreted in the bile within 24 h. The highest concentration of radioactivity in tissues was found at 1 h, except in the small and large intestines, followed by a rapid decrease in concentration. Only small amounts of radioactivity were found in the tissues 48 h after administration. Some of the radioactive materials in the urine were separated by thin‐layer chromatography and identified as N1 ,N4‐diacetyl‐2‐amino‐p‐phenylenediamine, N4‐acetyl‐2‐nitro‐p‐phenylenediamine, and unchanged nitro‐p‐phenylenediamine.

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