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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 8
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Research Article

The Metabolism of N-Ethyl-N-methylaniline by Rabbit Liver Microsomes: The Measurement of Metabolites by Gas-liquid Chromatography

J. W. Gorrod Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX; Institut für Pharmazeutische Chemie der Johann Wolfgang Goethe-Universität, 6 Frankfurt am Main, Georg-Voigt-Straβe, West Germany, 14
,
D. J. Temple Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX
&
A. H. Beckett Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX
Pages 453-463 | Received 02 Nov 1974, Published online: 14 Oct 2008

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R. A. H. J. Gilissen, L. Ferrari, R. J. Barnaby & M. Kajbaf. (2000) Human hepatic metabolism of a novel 2-carboxyindole glycine antagonist for stroke: in vitro-in vivo correlations. Xenobiotica 30:9, pages 843-856.
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M. KAJBAF, P. ROSSATO, J. R. BARNABY & M. PELLEGATTI. (1998) Metabolism of a novel CCK-B antagonist in rat, dog and human liver microsomes. Xenobiotica 28:2, pages 167-178.
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T. G. ALTUNTAS & J. W. GORROD. (1997) Comutagenesis-III. In vitro metabolism of 2-amino3-methylpyridine : the effect of various potential inhibitors, activators and inducers. Xenobiotica 27:11, pages 1103-1111.
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J. W. Gorrod & M. Ulgen. (1994) Metabolic N-Oxidation of Diarylimines: A New Metabolic Reaction of Potential Toxicological Significance. Drug Metabolism Reviews 26:1-2, pages 241-252.
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J. W. Gorrod & J. Fang. (1993) On the metabolism of haloperidol. Xenobiotica 23:5, pages 495-508.
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M. Kajbaf, M. Jahanshahi, J. H. Lamb, J. W. Gorrod & S. Naylor. (1992) Bioanalytical applications of tandem mass spectrometry in the in vitro metabolism of the anticholinergic drug cimetropium bromide to detect differences in species metabolism. Xenobiotica 22:6, pages 641-655.
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J. W. Gorrod & A. Raman. (1989) Mines as Intermediates in Oxidative Aralkylamine Metabolism. Drug Metabolism Reviews 20:2-4, pages 307-339.
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J. W. Gorrod & N. J. Gooderham. (1987) The metabolism of N-benzyl-4-substituted anilines: factors influencing in vitro C- and N-oxidation. Xenobiotica 17:2, pages 165-177.
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L. A. Damani, M. S. Shaker, P. A. Crooks, C. S. Godin & C. Nwosu. (1986) N-Methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosy1-L-methioninedependent reaction. Xenobiotica 16:7, pages 645-650.
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J. W. Gorrod & M. Christou. (1986) Metabolic N-Hydroxylation of substituted acetophenone ixnines. I. Evidence for formation of isomeric oximes. Xenobiotica 16:6, pages 575-585.
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J. W. Gorrod & N. J. Gooderham. (1985) Microsomal N- and C-oxidation of 4-substituted N-benzylanilines. Xenobiotica 15:12, pages 1021-1031.
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J. W. Gorrord & L. H. Patterson. (1983) The metabolism of 4-substituted N-ethyl-N-methylanilines: III. Effect of various potential inhibitors, activators and inducers on α-C- and N-oxidation. Xenobiotica 13:9, pages 521-529.
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J. W. Gorrod & L. H. Patterson. (1983) The metabolism of 4-substituted-N-ethyl-N-methyl-anilines: II. Some factors influencing α-C- and N-oxidation. Xenobiotica 13:9, pages 513-520.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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L. A. Damani, J. Bryan, D. A. Cowan & J. W. Gorrod. (1980) The origin of 1-(3-pyridyl-N-oxide)ethanol as a metabolite of 3-acetylpyridine. Xenobiotica 10:7-8, pages 645-653.
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J. W. Gorrod & L. H. Patterson. (1980) Evidence for p-hydroxylation of N-ethyl-N-methylaniline. Xenobiotica 10:7-8, pages 603-610.
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J. W. Gorrod & L. A. Damani. (1979) Some factors involved in the N-oxidation of 3-substituted pyridines by microsomal preparations in vitro. Xenobiotica 9:4, pages 209-218.
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J. W. Gorrod, D. J. Temple & A. H. Beckett. (1979) The N- and α- C-Oxidation of N,N-Dialkylanilines by Rabbit Liver Microsomes in vitro. Xenobiotica 9:1, pages 17-25.
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A. H. Beckett & K. Haya. (1978) The Stereoselective Metabolism of Ethylamphetamine with Fortified Rabbit Liver Homogenates. Xenobiotica 8:2, pages 85-96.
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Arnold H. Beckett & G. Gordon Gibson. (1978) Stereochemistry of the Metabolic Incorporation of Oxygen into (+)- and (-)-N-Benzylamphetamine. Xenobiotica 8:2, pages 73-83.
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J. W. Gorrod & D. J. Temple. (1976) The Formation of an N-Hydroxymethyl Intermediate in the N-Demethylation of N-Methylcarbazole in vivo and in vitro. Xenobiotica 6:5, pages 265-274.
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A. H. Beckett & G. G. Gibson. (1975) Microsomal N-Hydroxylation of Dibenzylamine. Xenobiotica 5:11, pages 677-686.
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J. W. Gorrod, D. J. Temple & A. H. Beckett. (1975) The Differentiation of N-Oxidation and N-Dealkylation of N-Ethyl-N-methylaniline by Rabbit Liver Microsomes as Distinct Metabolic Routes. Xenobiotica 5:8, pages 465-474.
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