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Xenobiotica
the fate of foreign compounds in biological systems
Volume 5, 1975 - Issue 8
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Research Article

The Differentiation of N-Oxidation and N-Dealkylation of N-Ethyl-N-methylaniline by Rabbit Liver Microsomes as Distinct Metabolic Routes

J. W. Gorrod Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX
,
D. J. Temple Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX; Institut für Pharmazeutische Chemie der Johann Wolfgang Goethe-Universität, 6 Frankfurt am Main, Georg-Voigt-Straβe, West Germany, 14
&
A. H. Beckett Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, UK, SW3 6LX
Pages 465-474 | Received 02 Nov 1974, Published online: 14 Oct 2008

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J. W. Gorrord & L. H. Patterson. (1983) The metabolism of 4-substituted N-ethyl-N-methylanilines: III. Effect of various potential inhibitors, activators and inducers on α-C- and N-oxidation. Xenobiotica 13:9, pages 521-529.
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J. W. Gorrod & L. H. Patterson. (1983) The metabolism of 4-substituted-N-ethyl-N-methyl-anilines: II. Some factors influencing α-C- and N-oxidation. Xenobiotica 13:9, pages 513-520.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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G. Hallström, B. Lindeke & E. Anderson. (1981) Metabolism of N-(5-pyrrolidinopent-3-ynyl)-succinimide (BL 14) in rat liver preparations. Characterization of four oxidative reactions. Xenobiotica 11:7, pages 459-471.
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J. W. Gorrod & L. H. Patterson. (1980) Evidence for p-hydroxylation of N-ethyl-N-methylaniline. Xenobiotica 10:7-8, pages 603-610.
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J. W. Gorrod & L. A. Damani. (1979) The effect of various potential inhibitors, activators and inducers on the N-oxidation of 3-substituted pyridines in vitro. Xenobiotica 9:4, pages 219-226.
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J. W. Gorrod & L. A. Damani. (1979) Some factors involved in the N-oxidation of 3-substituted pyridines by microsomal preparations in vitro. Xenobiotica 9:4, pages 209-218.
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J. W. Gorrod, D. J. Temple & A. H. Beckett. (1979) The N- and α- C-Oxidation of N,N-Dialkylanilines by Rabbit Liver Microsomes in vitro. Xenobiotica 9:1, pages 17-25.
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H. P. A. Illing, M. A. Yeomaxs, P. A. Rising & P. Johnson. (1977) Enzymic Dealkylation of a Substituted Aminoacetamidobenzophenone and Cyclization to the Corresponding Benzodiazepine in vitro. Xenobiotica 7:7, pages 439-454.
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Articles from other publishers (13)

Marcus Taupp, Frank Heckel, Dag Harmsen & Peter Schreier. (2006) Direct trapping of formaldehyde formed via oxidative N-demethylation of N,N-dialkylarylamines by Bacillus megaterium using cysteamine derivatization. Journal of Microbiological Methods 67:2, pages 357-362.
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M. R. Hadley, H. G. Oldham, L. A. Damani & A. J. Hutt. (1998) High performance liquid chromatographic analysis of theIn vitro N-dealkylated andN-oxide metabolites ofN-ethyl-N-methylaniline: Methodology for the determination of enzyme activity and stereoselectivity ofN-oxidation. Chromatographia 48:9-10, pages 664-670.
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Mark R. Hadley, Harriet G. Oldham, Patrick Camilleri, Lyaquatali A. Damani & Andrew J. Hutt. (1996) Species differences in the stereoselectivity ofN-oxygenation ofN-ethyl-N-methylaniline in vitro. Chirality 8:6, pages 430-440.
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P. Hlavica & I. Golly. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 71 90 .
R.C. HILES & K.M. ABDO. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 197 201 .
Ramendra N. Pandey, Arthur P. Armstrong & Paul F. Hollenberg. (1989) Oxidative N-demethylation of N,N-dimethylaniline by purified isozymes of cytochrome P-450. Biochemical Pharmacology 38:13, pages 2181-2185.
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M. Gibson, C.J. Soper, R.T. Parfitt & G.J. Sewell. (1984) Studies on the mechanism of microbial N-demethylation of codeine by cell-free extracts of Cunninghamella bainieri. Enzyme and Microbial Technology 6:10, pages 471-475.
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Mark Gibson, Colin J. Soper & Robert T. Parfitt. (1984) Application of 13C-n.m.r. spectroscopy to study the mechanism of N-demethylation of [NMe13C] codeine by cell-free extracts of Cunninghamella bainieri. Analytica Chimica Acta 163, pages 175-183.
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Janine Rose & Neal CastagnoliJr.Jr.. (2006) The metabolism of tertiary amines. Medicinal Research Reviews 3:1, pages 73-88.
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David A. Cowan, Laurence H. Patterson, Lyaquatali A. Damani & John W. Gorrod. (1982) Metabolism of 4-substituted-N-ethyl-N-methylanilines: Chromatographic and mass spectrometric identification ofN-oxidation metabolic products formedin vitro. Biological Mass Spectrometry 9:6, pages 233-240.
Crossref
G. Hallström, B. Lindeke, A.-H. Khuthier & M.A. Al-Iraqi. (1981) Microsomal formation and chemical decomposition of pargyline N-oxide. Chemico-Biological Interactions 34:2, pages 185-200.
Crossref
P. Hlavica & S. Hülsmann. 1980. Microsomes, Drug Oxidations and Chemical Carcinogenesis. Microsomes, Drug Oxidations and Chemical Carcinogenesis 217 220 .
Neal CastagnoliJr.Jr.. 1978. Stimulants. Stimulants 335 387 .

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