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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 9
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Original Article

Metabolism of [14C]Paracetamol and its Interactions with Aspirin in Hamsters

L. T. Wong Drug Research Laboratories, Health Protection Branch, Health and Welfare Canada, Ottawa, K1A OL2, Canada
,
G. Solomonraj Drug Research Laboratories, Health Protection Branch, Health and Welfare Canada, Ottawa, K1A OL2, Canada
&
B. H. Thomas Drug Research Laboratories, Health Protection Branch, Health and Welfare Canada, Ottawa, K1A OL2, Canada
Pages 575-584 | Received 12 Jan 1976, Published online: 30 Sep 2009

Citations (15)

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M. E. Veronese, S. McLean, C. A. D'souza & N. W. Davies. (1985) Formation of reactive metabolites of phenacetin in humans and rats. Xenobiotica 15:11, pages 929-940.
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A. Warrander, J. M. Allen & R. S. Andrews. (1985) Incorporation of radiolabelled amino acids into the sulphur-containing metabolites of paracetamol by the hamster. Xenobiotica 15:11, pages 891-897.
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Mitsuru Tateishi. (1983) Methylthlolated Metabolites. Drug Metabolism Reviews 14:6, pages 1207-1234.
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S. J. Hart, K. Healey, M. C. Smail & I. C. Calder. (1982) 3-Thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol. Xenobiotica 12:6, pages 381-386.
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Articles from other publishers (11)

L van Bree, E J Groot & J de Vries. (1989) Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4‘-dichlorobiphenyl, phenobarbitone and pregnenolone-16-α-carbonitrile. Journal of Pharmacy and Pharmacology 41:5, pages 343-345.
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Arthur J. L. Cooper & John T. Pinto. 2008. Advances in Bioactivation Research. Advances in Bioactivation Research 1 24 .
Humeida A. El-Obeid & Abdullah A. Al-Badr. 1985. 551 596 .
K.D. Rainsford. 1984. Aspirin and the Salicylates. Aspirin and the Salicylates 148 271 .
A. L. Burlingame, K. Straub & T. A. Baillie. (2005) Mass spectrometric studies on the molecular basis of xenobiotic‐induced toxicities. Mass Spectrometry Reviews 2:3, pages 331-387.
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Michael C. Savides & Frederick W. Oehme. (2006) Acetaminophen and its toxicity. Journal of Applied Toxicology 3:2, pages 96-111.
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S. J. Hart, I. C. Calder & J. D. Tange. (1982) The metabolism and toxicity of paracetamol in Sprague-Dawley and wistar rats. European Journal of Drug Metabolism and Pharmacokinetics 7:3, pages 203-222.
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S.J. Hart, R. Tontodonati & I.C. Calder. (1981) Reversed-phase chromatography of urinary metabolites of paracetamol using ion suppression and ion pairing. Journal of Chromatography B: Biomedical Sciences and Applications 225:2, pages 387-405.
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Ad J.M. Seegers, Martin Olling, Lowie P. Jager & Jacobus van Noordwijk. (1980) Interactions of aspirin with acetaminophen and caffeine in rat stomach: Pharmacokinetics of absorption and accumulation in gastric mucosa. Journal of Pharmaceutical Sciences 69:8, pages 900-906.
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M. TATEISHI & HIROTOSHI SHIMIZU. 1980. Enzymatic Basis of Detoxication. Enzymatic Basis of Detoxication 121 130 .
M. Tateishi, S. Suzuki & H. Shimizu. (1978) Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.. Journal of Biological Chemistry 253:24, pages 8854-8859.
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