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Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 7
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Research Article

The Metabolism of a Substituted Aminoacetamido-benzophenone and Cyclization to the Corresponding Benzodiazepine in the Rat in vivo

P. A. Rising Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
,
H. P. A. Illing Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
,
P. Johnson Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
&
M. A. Yeomans Drug Development, Hoechst Pharmaceutical Research Laboratories, Walton Manor, Walton Milton Keynes, MK7 7AJ, UK
Pages 425-437 | Received 24 Aug 1976, Published online: 22 Sep 2008

Citations (7)

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Read on this site (3)

T. Sato, M. Konishi, T. Ago, Y. Nakagawa, K. Iwatani & Y. Mori. (1980) Metabolism of peptido-aminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N′-glycyl-glycinanilide) in dogs. Xenobiotica 10:2, pages 125-133.
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P. Johnson & P. A. Rising. (1978) Techniques for Assessment of Biliary Excretion and Enterohepatic Circulation in the Rat. Xenobiotica 8:1, pages 27-36.
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H. P. A. Illing, M. A. Yeomaxs, P. A. Rising & P. Johnson. (1977) Enzymic Dealkylation of a Substituted Aminoacetamidobenzophenone and Cyclization to the Corresponding Benzodiazepine in vitro. Xenobiotica 7:7, pages 439-454.
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Articles from other publishers (4)

N. Ya. Golovenko, M. Yu. Totrova, O. P. Rudenko & O. P. Povolotskaya. (1986) Anticonvulsive activity of peptidoamidobenzophenones. Pharmaceutical Chemistry Journal 20:7, pages 467-471.
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N. Ya. Golovenko & M. Yu. Totrova. (1985) Strategy of the search for physiologically active substances according to their metabolites (survey). Pharmaceutical Chemistry Journal 19:3, pages 163-170.
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Shin'Ichirō Hashimoto & Shirō Takahashi. (2006) Synthesis of deuterium‐labelled peptido‐aminobenzophenone [4‐chloro‐2‐(2′‐chlorobenzoyl)‐N‐(glycylglycyl)‐N‐methyl‐anilide] and its metabolites. Journal of Labelled Compounds and Radiopharmaceuticals 19:7, pages 867-880.
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HM Kellner, C. Baeder, O. Christ, W. Heptner, I. Hornke & RM Ings. (2012) Kinetics and metabolism of nomifensine in animals.. British Journal of Clinical Pharmacology 4:S2.
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