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Xenobiotica
the fate of foreign compounds in biological systems
Volume 7, 1977 - Issue 3
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Original Article

Microbial Models of Mammalian Metabolism O-Demethylations of Papaverine

John P. Rosazza Division of Medicinal Chemistry and Natural Products, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA
,
Marianne Kammer Division of Medicinal Chemistry and Natural Products, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA
,
Leisa Youel Division of Medicinal Chemistry and Natural Products, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA
,
Robert V. Smith Drug Dynamics Institute and Department of Pharmacology, College of Pharmacy, University of Texas at Austin, Austin, Texas, 78712, USA
,
Paul W. Erhardt Drug Dynamics Institute and Department of Pharmacology, College of Pharmacy, University of Texas at Austin, Austin, Texas, 78712, USA
,
Duyen H. Truong Drug Dynamics Institute and Department of Pharmacology, College of Pharmacy, University of Texas at Austin, Austin, Texas, 78712, USA
&
Steven W. Leslie Drug Dynamics Institute and Department of Pharmacology, College of Pharmacy, University of Texas at Austin, Austin, Texas, 78712, USA
 show all
Pages 133-143 | Received 29 May 1976, Published online: 30 Sep 2009

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Françoise Bister-Miel, Catherine Agier, Michèle Bury, Claude Viel & Jean Louis Guignard. (1988) Biotransformations comparées de benzylisoquinoléines par des suspensions cellulaires végétales non productrices d'alcaloïdes. Bulletin de la Société Botanique de France. Lettres Botaniques 135:1, pages 57-70.
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O. K. Sebek. (1983) Fungal Transformations as a Useful Method for the Synthesis of Organic Compounds. Mycologia 75:2, pages 383-394.
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Articles from other publishers (29)

Nico D. Fessner, Christopher Grimm, Matic Srdič, Hansjörg Weber, Wolfgang Kroutil, Ulrich Schwaneberg & Anton Glieder. (2021) Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A4. ChemCatChem 14:1.
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B. Kaboudin & M. Sohrabi. (2021) Chemistry and synthesis of major opium alkaloids: a comprehensive review. Journal of the Iranian Chemical Society 18:12, pages 3177-3218.
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Christopher Grimm, Mattia Lazzarotto, Simona Pompei, Johanna Schichler, Nina Richter, Judith E. Farnberger, Michael Fuchs & Wolfgang Kroutil. (2020) Oxygen-Free Regioselective Biocatalytic Demethylation of Methyl-phenyl Ethers via Methyltransfer Employing Veratrol- O -demethylase . ACS Catalysis 10:18, pages 10375-10380.
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Jan M Klenk, Max-Philipp Fischer, Paulina Dubiel, Mahima Sharma, Benjamin Rowlinson, Gideon Grogan & Bernhard Hauer. (2019) Identification and characterization of cytochrome P450 1232A24 and 1232F1 from Arthrobacter sp. and their role in the metabolic pathway of papaverine. The Journal of Biochemistry 166:1, pages 51-66.
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Chen Shen, Wanli Zhao, Xuming Liu & Jihua Liu. (2018) Enzyme-catalyzed regio-selective demethylation of papaverine by CYP105D1. Biotechnology Letters 41:1, pages 171-180.
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N. Fan, C. H. Du, J. Q. Xu, Y. X. Xu, B. Y. Yu & J. Zhang. (2017) Glycosylation and sulfation of 4-methylumbelliferone by Gliocladium deliquescens NRRL 1086. Applied Biochemistry and Microbiology 53:1, pages 85-93.
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Irfan Pervaiz, Saeed Ahmad, Muhammad Fahad Mukhtar, Adeel Arshad, Muhammad Imran & Wajahat Mahmood. (2015) Microbial Biotransformation of Dexamethasone by Bacillus Subtilis (ATCC 6051). Pharmaceutical Chemistry Journal 49:6, pages 405-408.
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Sepuri Asha & Maravajhala Vidyavathi. (2009) Cunninghamella – A microbial model for drug metabolism studies – A review. Biotechnology Advances 27:1, pages 16-29.
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Mahmud Tareq Hassan Khan & Arjumand Ather. 2007. Bioactive Heterocycles IV. Bioactive Heterocycles IV 99 122 .
M. Sanchez-Gonzalez & J. P. N. Rosazza. (2004) Microbial Transformations of Chalcones:  Hydroxylation, O -Demethylation, and Cyclization to Flavanones . Journal of Natural Products 67:4, pages 553-558.
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Khalid A. El Sayed. (2000) Microbial transformation of papaveraldine. Phytochemistry 53:6, pages 675-678.
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R. Azerad. 1999. Biotransformations. Biotransformations 169 218 .
K. Anil Kumar, B.S.Vijay Kumar, B. Laxminarayana & S. Ananthanarayanan. 1998. Recent Advances In Basic and Applied Aspects of Industrial Catalysis, Proceedings of 13th National Symposium and Silver Jubilee Symposium of Catalysis of India. Recent Advances In Basic and Applied Aspects of Industrial Catalysis, Proceedings of 13th National Symposium and Silver Jubilee Symposium of Catalysis of India 541 546 .
C. Viel, F. Bister-Miel & J. L. Guignard. 1993. Medicinal and Aromatic Plants IV. Medicinal and Aromatic Plants IV 326 338 .
Joël Briand, Henri Blehaut, Régis Calvayrac & Danielle Laval-Martin. (1992) Use of a microbial model for the determination of drug effects on cell metabolism and energetics: Study of citrulline-malate. Biopharmaceutics & Drug Disposition 13:1, pages 1-22.
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David A. Griffiths, David J. Best & Serge G. Jezequel. (1991) The screening of selected microorganisms for use as models of mammalian drug metabolism. Applied Microbiology and Biotechnology 35:3, pages 373-381.
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Julio C. Davila, Patrick J. Davis & Daniel Acosta. (1991) Changes in glutathione and cellular energy as potential mechanisms of papaverine-induced hepatotoxicity in Vitro. Toxicology and Applied Pharmacology 108:1, pages 28-36.
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Julio C. Davila, Chandrasekara G. Reddy, Patrick J. Davis & Daniel Acosta. (1990) Toxicity assessment of paraverine hydrochloride and papaverine-derived metabolites in primary cultures of rat hepatocytes. In Vitro Cellular & Developmental Biology 26:5, pages 515-524.
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H.G. Davies, R.H. Green, D.R. Kelly & Stanley M. Roberts. 1989. Biotransformations in Preparative Organic Chemistry. Biotransformations in Preparative Organic Chemistry 221 257 .
Mohamed S. Hifnawy & Farid J. Muhtadi. 1988. 367 447 .
John B. Sutherland. (1986) Demethylation of Veratrole by Cytochrome P-450 in Streptomyces setonii . Applied and Environmental Microbiology 52:1, pages 98-100.
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F.Sima Sariaslani & John P.N. Rosazza. (1984) Biocatalysis in natural products chemistry. Enzyme and Microbial Technology 6:6, pages 242-253.
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F. Sima Sariaslani & John P. Rosazza. (1983) Novel Biotransformations of 7-Ethoxycoumarin by Streptomyces griseus . Applied and Environmental Microbiology 46:2, pages 468-474.
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J Wu & L K Wong. (1981) Microbial transformations of 7,2-dimethylbenz[a]anthracene. Applied and Environmental Microbiology 41:3, pages 843-845.
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H.L. Holland. 1981. 323 400 .
Klaus HAASE-ASCHOFF & Franz LINGENS. (1979) Mikrobieller Abbau von Papaverin. Hoppe-Seyler´s Zeitschrift für physiologische Chemie 360:1, pages 621-632.
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John P. Rosazza & Robert V. Smith. 1979. 169 208 .
Geng-Shuen Wu, Thomas Nabih, Leisa Youel, Wanda Peczynska-Czoch & John P. Rosazza. (1978) Microbial Transformations of Natural Antitumor Agents: O -Demethylation of Vindoline by Sepedonium chrysospermum . Antimicrobial Agents and Chemotherapy 14:4, pages 601-604.
Crossref
J. P. N. Rosazza. 1978. Antitumor Antibiotics. Antitumor Antibiotics 58 68 .

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