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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 1
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Review Article

Novel Pathways in Drug Metabolism

Peter Jenner University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, Denmark Hill, London, SE 5, UK
&
Bernard Testa School of Pharmacy, University of Lausanne, Place du Chateau, CH-1005, Lausanne, Switzerland
Pages 1-25 | Received 24 Feb 1977, Published online: 22 Sep 2008

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Timothy L. Macdonald & M. W. Anders. (1983) Chemical Mechanisms of Halocarbon Metabolism. CRC Critical Reviews in Toxicology 11:2, pages 85-120.
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Peter G. Dayton & James E. Sanders. (1983) Dose-Dependent Pharmacokinetics: Emphasis on Phase I Metabolism. Drug Metabolism Reviews 14:3, pages 347-405.
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Björn Lindeke. (1982) The Non-and Postenzymatic Chemistry of N-Oxygenated Molecules. Drug Metabolism Reviews 13:1, pages 71-121.
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Bernard Testa. (1982) Nonenzymatic Contributions to Xenobiotic Metabolism. Drug Metabolism Reviews 13:1, pages 25-50.
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R. Kaul, B. Hempel & G. Kiefer. (1982) Structure of a novel sulphur-containing metabolite of Acluracil (1-allyl-3,5-diethyl-6-chlorouracil). Xenobiotica 12:8, pages 495-498.
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John Caldwell. (1981) The Current Status of Attempts to Predict Species Differences in Drug Metabolism. Drug Metabolism Reviews 12:2, pages 221-237.
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Bernard Testa & Peter Jenner. (1978) Novel Drug Metabolites Produced by Functionalization Reactions: Chemistry and Toxicology. Drug Metabolism Reviews 7:2, pages 325-369.
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A H Beckett, G E Navas, A J Hutt & M Farag. (1979) Disappearing N -hydroxy compounds . Journal of Pharmacy and Pharmacology 31:1, pages 476-477.
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V. G. Gorokhova, A. G. Gorokhov, E. E. Kuznetsova & A. A. Runovich. (2008) Rapid evaluation of the functional activity of the hepatic monooxygenase system. Pharmaceutical Chemistry Journal 41:12.
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B. Testa. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 133 166 .
Donald J. AbrahamBernard Testa & William Soine. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 431 498 .
Yoshihisa Kato, Koichi Haraguchi, Koichi Tomiyasu, Hiroyuki Saito, Tomoo Shibahara, Yoshito Masuda & Ryohei Kimura. (1999) The role of 3-methylsulfonyl-2,2′,4′,5,5′-pentachlorobiphenyl, a metabolite of 2,2′,4,5,5′-pentachlorobiphenyl, in the induction of hepatic microsomal drug-metabolizing enzymes by 2,2′,4,5,5′-pentachlorobiphenyl in rats. Environmental Toxicology and Pharmacology 8:1, pages 39-47.
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Masayuki Uchimura, Roger Sandeaux & Christian Larroque. (1999) The Enzymatic Detoxifying System of a Native Mediterranean Scorpio Fish Is Affected by Caulerpa taxifolia in Its Environment . Environmental Science & Technology 33:10, pages 1671-1674.
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R. J. Schmidt & L. Y. Chung. (1992) Biochemical responses of skin to allergenic and non-allergenic nitrohalobenzenes. Archives of Dermatological Research 284:7, pages 400-408.
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Yoshihisa Kato, Toshihiro Kogure, Masaki Sato & Ryohei Kimura. (1988) Contribution of methylsulfonyl metabolites of m-dichlorobenzene to the heme metabolic enzyme induction by the parent compound in rat liver. Toxicology and Applied Pharmacology 96:3, pages 550-559.
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Sylvie Fournel & John Caldwell. (1986) The metabolic chiral inversion of 2-phenylpropionic acid in rat, mouse and rabbit. Biochemical Pharmacology 35:23, pages 4153-4159.
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Yoshihisa Kato, Toshihiro Kogure, Masaki Sato, Toshiro Murata & Ryohei Kimura. (1986) Evidence that methylsulfonyl metabolites of m-dichlorobenzene are causative substances of induction of hepatic microsomal drug-metabolizing enzymes by the parent compound in rats. Toxicology and Applied Pharmacology 82:3, pages 505-511.
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G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1986. Introduction to Drug Metabolism. Introduction to Drug Metabolism 1 37 .
John A. Nash, Laurence J. King, Edward A. Lock & Trevor Green. (1984) The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity. Toxicology and Applied Pharmacology 73:1, pages 124-137.
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Jean-Michel Maître, Gilles Boss & Bernard Testa. (1984) High-performance liquid chromatographic separation of the enantiomers of anti-inflammatory 2-arylpropionates: suitability of the method for in vitro metabolic studies. Journal of Chromatography A 299, pages 397-403.
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Christian Malaveille & Helmut Bartsch. 1984. Handbook of Mutagenicity Test Procedures. Handbook of Mutagenicity Test Procedures 615 641 .
A. L. Burlingame, K. Straub & T. A. Baillie. (2005) Mass spectrometric studies on the molecular basis of xenobiotic‐induced toxicities. Mass Spectrometry Reviews 2:3, pages 331-387.
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Ryohei Kimura, Masahiro Kawai, Masaki Sato, Tachio Aimoto & Toshiro Murata. (1983) Induction of hepatic microsomal drug-metabolizing enzymes by sulfur-containing metabolites of chlorinated benzenes in rats. Toxicology and Applied Pharmacology 67:3, pages 338-345.
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Ravinder Kaul, Bernd Hempel & Gebhard Kiefer. (1982) 2- 14C-1 -Allyl-3,5-diethyl-6-chlorouracil II: Isolation and Structures of the Major Sulfur-Free and Three Minor Sulfur-Containing Metabolites and Mechanism of Biotransformation. Journal of Pharmaceutical Sciences 71:8, pages 897-900.
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BJÖRN LINDEKE & ARTHUR K. CHO. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 105 126 .
H. Wyman Dorough & Sue K. Ballard. 1982. Biodegradation of Pesticides. Biodegradation of Pesticides 3 20 .
H. Bartsch, T. Kuroki, M. Roberfroid & C. Malaveille. 1982. Chemical Mutagens. Chemical Mutagens 95 161 .
Dieter Reichert. (2006) Giftung körperfremder Stoffe durch Konjugationsreaktionen. Angewandte Chemie 93:2, pages 135-142.
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Vernon L. Singleton. 1981. 149 242 .
R. Kaul, G. Kiefer & B. Hempel. (1981) Mechanism of formation of SCH3-metabolites investigated on the biotransformation of 1-allyl-3,5-diethyl-6-chlorouracil in rabbits. Chemosphere 10:8, pages 929-934.
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M. B. Roberfroid. (1980) Metabolic activation of drugs in mutagenicity tests in vitro. Archives of Toxicology 46:1-2, pages 181-193.
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CHARLES B. KASPER & DONABY HENTON. 1980. Enzymatic Basis of Detoxication. Enzymatic Basis of Detoxication 3 36 .
PETER G. WISLOCKI, GERALD T. MIWA & ANTHONY Y.H. LU. 1980. Enzymatic Basis of Detoxication. Enzymatic Basis of Detoxication 135 182 .
Eino Hietanen. (1980) Modification of hepatic drug metabolizing enzyme activities and their induction by dietary protein. General Pharmacology: The Vascular System 11:5, pages 443-450.
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Linda S. Birnbaum & Malcolm B. Baird. (1979) Senescent changes in rodent hepatic epoxide metabolism. Chemico-Biological Interactions 26:3, pages 245-256.
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Bruce H. Migdalof, Kishin J. Kripalani & Sampat M. Singhvi. 1979. Annual Reports in Medicinal Chemistry Volume 14. Annual Reports in Medicinal Chemistry Volume 14 188 197 .
Bruce H. Migdalof. 1978. 196 205 .
D. Reichert, H. W. Werner, M. Metzler & D. Henschler. (1978) Molecular mechanism of 1,1-dichloroethylene toxicity: excreted metabolites reveal different pathways of reactive intermediates. Archives of Toxicology 42:3, pages 159-169.
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G. Koss, W. Koransky & K. Steinbach. (1978) Studies on the toxicology of hexachlorobenzene. Archives of Toxicology 42:1, pages 19-31.
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