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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 11
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Research Article

The Reduction of Nitrobenzoic Acids in the Rat

D. M. Gardner Pharmacology, Faculty of Medicine, University of Southampton, Southampton, SO9 3TU, UK
&
A. G. Renwick Pharmacology, Faculty of Medicine, University of Southampton, Southampton, SO9 3TU, UK
Pages 679-690 | Received 16 Jun 1978, Published online: 22 Sep 2008

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O. Ueda, S. Kitamura, R. Kubo, Y. Yano, Y. Kanzaki, T. Fujimoto, K. Tatsumi & S. Ohta. (2001) Metabolism of 2-nitrofluorene, 2-aminofluorene and 2-acylaminofluorenes in rat and dog and the role of intestinal bacteria. Xenobiotica 31:1, pages 33-49.
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Ian R. Rowland, Anthony K. Mallett & Alan Wise. (1985) The Effect of Diet on the Mammalian Gut Flora and Its Metabolic Activities. CRC Critical Reviews in Toxicology 16:1, pages 31-103.
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Mitsuo Nakao & Yasushi Takeda. (1983) Distribution, excretion, and metabolism of nitro‐p‐phenylenediamine in rats. Journal of Toxicology and Environmental Health 11:1, pages 93-100.
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E. J. A. Kuzniar & S. P. James. (1981) Influence of the gut microflora on the metabolism of 4-nitrobenzoic acid in the marmoset. Xenobiotica 11:10, pages 675-683.
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V. Facchini & L. A. Griffiths. (1980) Metabolism of nitromide in the rat. II. Sites of nitro-reduction. Xenobiotica 10:4, pages 299-305.
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V. Facchini & L. A. Griffiths. (1980) The metabolic fate of nitromide in the rat. I. Metabolism and excretion. Xenobiotica 10:4, pages 289-297.
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Ovanes G. Mekenyan, Petko I. Petkov, Stefan V. Kotov, Stoyanka Stoeva, Verginia B. Kamenska, Sabcho D. Dimitrov, Masamitsu Honma, Makoto Hayashi, Romualdo Benigni, E. Maria Donner & Grace Patlewicz. (2012) Investigating the Relationship between in Vitro–in Vivo Genotoxicity: Derivation of Mechanistic QSAR Models for in Vivo Liver Genotoxicity and in Vivo Bone Marrow Micronucleus Formation Which Encompass Metabolism. Chemical Research in Toxicology 25:2, pages 277-296.
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Shigeyuki Kitamura, Kazumi Sugihara, Mie Kuwasako & Kiyoshi Tatsumi. (1997) The Role of Mammalian Intestinal Bacteria in the Reductive Metabolism of Zonisamide. Journal of Pharmacy and Pharmacology 49:3, pages 253-256.
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Peter E. J. Groenewegen & Jan A. M. de Bont. (1992) Degradation of 4-nitrobenzoate via 4-hydroxylaminobenzoate and 3,4-dihydroxybenzoate in Comamonas acidovorans NBA-10. Archives of Microbiology 158:5, pages 381-386.
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IAN R. ROWLAND. 1986. Bioreduction in the Activation of Drugs. Bioreduction in the Activation of Drugs 27 32 .
Ian R. Rowland. (1986) Reduction by the gut microflora of animals and man. Biochemical Pharmacology 35:1, pages 27-32.
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PETER GOLDMAN. 1983. Human Intestinal Microflora in Health and Disease. Human Intestinal Microflora in Health and Disease 241 263 .
A.G. Renwick. 1983. Biological Basis of Detoxication. Biological Basis of Detoxication 151 179 .
J. Sims & A.G. Renwick. (1983) The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat. Toxicology and Applied Pharmacology 67:1, pages 132-151.
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Andrew G. Renwick, Susan P. Evans, Trevor W. Sweatman, Janet Cumberland & Charles F. George. (1982) The role of the gut flora in the reduction of sulphinpyrazone in the rat. Biochemical Pharmacology 31:16, pages 2649-2656.
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A.G. Renwick. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 3 28 .
Ronald P. Mason. 1982. Free Radicals in Biology. Free Radicals in Biology 161 222 .
D.S. HEWICK. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 151 170 .

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