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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 4
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Original Article

The effect of various potential inhibitors, activators and inducers on the N-oxidation of 3-substituted pyridines in vitro

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Pages 219-226 | Received 17 Nov 1978, Published online: 30 Sep 2009

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J. W. Gorrod & M. Ulgen. (1994) Metabolic N-Oxidation of Diarylimines: A New Metabolic Reaction of Potential Toxicological Significance. Drug Metabolism Reviews 26:1-2, pages 241-252.
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Raymond f. Novak, Karen l. Kaul & Sang Geon Kim. (1989) Induction of the Alcohol Inducible Form of Cytochrome P-450 By Nitrogen-Containing Heterocycles: Effects on Pyridine It-Oxide Production. Drug Metabolism Reviews 20:2-4, pages 781-792.
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T. J. Wilke, W. R. Jondorf & G. Powis. (1989) Oxidative metabolism of 14C-pyridine by human and rat tissue subcellular fractions. Xenobiotica 19:9, pages 1013-1022.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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L. A. Damani, P. A. Crooks, M. S. Shaker, J. Caldwell, J. D'souza & R. L. Smith. (1982) Species differences in the metabolic C- and N-oxidation, and N-methylation of [14C]pyridine in vivo. Xenobiotica 12:8, pages 527-534.
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Bernard Testa & Peter Jenner. (1981) Inhibitors of Cytochrome P-450s and Their Mechanism of Action. Drug Metabolism Reviews 12:1, pages 1-117.
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L. A. Damani, J. Bryan, D. A. Cowan & J. W. Gorrod. (1980) The origin of 1-(3-pyridyl-N-oxide)ethanol as a metabolite of 3-acetylpyridine. Xenobiotica 10:7-8, pages 645-653.
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Articles from other publishers (25)

Domenico Gadaleta, Serena Manganelli, Alberto Manganaro, Nicola Porta & Emilio Benfenati. (2016) A knowledge-based expert rule system for predicting mutagenicity (Ames test) of aromatic amines and azo compounds. Toxicology 370, pages 20-30.
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Finis L. Cavender. 2003. Patty's Toxicology. Patty's Toxicology 1 84 .
M E McManus, D S Davies, A R Boobis, P H Grantham & P J Wirth. (1987) Guanethidine N -oxidation in human liver microsomes . Journal of Pharmacy and Pharmacology 39:12, pages 1052-1055.
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C A Joseph & P A F Dixon. (1984) A possible cytochrome P-450-mediated N -oxidation of diethylcarbamazine . Journal of Pharmacy and Pharmacology 36:10, pages 711-712.
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Zvi RappoportPeter Hlavica & Michael Lehnerer. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Finis L. Cavender. 2001. Patty's Toxicology. Patty's Toxicology.
Finis L. Cavender. 2003. Patty's Toxicology. Patty's Toxicology.
Gary P. Carlson. (1996) Comparison of the effects of pyridine and its metabolites on rat liver and kidney. Toxicology Letters 85:3, pages 173-178.
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Peter Hlavica & Michael Lehnerer. (2006) Some aspects of the role of cytochrome P‐450 isozymes in the n‐oxidative transformation of secondary and tertiary amine compounds. Journal of Biochemical Toxicology 10:5, pages 275-285.
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P. A. Crooks. 1993. Nicotine and Related Alkaloids. Nicotine and Related Alkaloids 81 109 .
Hyesook Kim, Sang G. Kim, Min-Young Lee & Raymond F. Novak. (1992) Evidence for elevation of cytochrome P4502E1 (alcohol-inducible form) mRNA levels in rat kidney following pyridine administration. Biochemical and Biophysical Research Communications 186:2, pages 846-853.
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RALPH L. REED. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 259 267 .
AZIZ EL-HRAIKI. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 225 231 .
Michel Charest, Guy Rossignol & Andre Castonguay. (1989) In vitro and in vivo modulation of the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in hamster lung tissues. Chemico-Biological Interactions 71:2-3, pages 265-278.
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L.A. Damani & A.A. Houdi. (1988) CYTOCHROME P-450 AND FAD-MONOOXYGENASE MEDIATED S- AND N-OXYGENATIONS. Drug Metabolism and Drug Interactions 6:3-4.
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K. El-Ghomari & J. W. Gorrod. (1987) Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines. European Journal of Drug Metabolism and Pharmacokinetics 12:4, pages 253-258.
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John A. Thompson, Kenneth J. Norris & Dennis R. Petersen. (1985) Isolation and analysis of N-oxide metabolites of tertiary amines: Quantitation of nicotine-1′-N-oxide formation in mice. Journal of Chromatography B: Biomedical Sciences and Applications 341, pages 349-359.
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. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 673 731 .
L.A. Damani & D.E. Case. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 223 246 .
Bernd Clement. (2006) In vitro Untersuchungen zur mikrosomalen N‐Oxidation N‐substituierter Benzamidine. Archiv der Pharmazie 317:11, pages 925-933.
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A. Jori, D. Calamari, F. Cattabeni, A. Di Domenico, C.L. Galli, E. Galli & V. Silano. (1983) Ecotoxicological profile of pyridine. Ecotoxicology and Environmental Safety 7:3, pages 251-275.
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L.A. DAMANI & P.A. CROOKS. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 69 89 .
G. Hallström, B. Lindeke, A.-H. Khuthier & M.A. Al-Iraqi. (1981) Microsomal formation and chemical decomposition of pargyline N-oxide. Chemico-Biological Interactions 34:2, pages 185-200.
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J.W. Gorrod, J. Bryan, D.A. Cowan & L.A. Damani. 1980. Microsomes, Drug Oxidations and Chemical Carcinogenesis. Microsomes, Drug Oxidations and Chemical Carcinogenesis 961 964 .
J. W. Gorrod & L. A. Damani. (1980) The metabolic N-oxidation of 3-substituted pyridines in various animal species in vivo. European Journal of Drug Metabolism and Pharmacokinetics 5:1, pages 53-57.
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