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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 11
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Research Article

1,2-Dichloropropane: metabolism and fate in the rat

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Pages 835-846 | Received 23 May 1980, Published online: 22 Sep 2008

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Makoto Take, Michiharu Matsumoto, Tetsuya Takeuchi, Mitsuru Haresaku, Hitomi Kondo, Hideki Senoh, Yumi Umeda, Takeji Takamura-Enya & Shoji Fukushima. (2014) Inhalation exposure to 1,2-dichloropropane: Distribution of blood and tissue concentrations of 1,2-dichloropropane in rats during and after exposure. Journal of Environmental Science and Health, Part A 49:12, pages 1341-1348.
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M. J. Bartels & C. Timchalk. (1990) 1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat. Xenobiotica 20:10, pages 1035-1042.
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M. S. Dobbie, K. E. Porter & A. R. Jones. (1988) Is the Nephrotoxicity of (R)-3-Chlorolactate in the Rat Caused by 3-Chloropyruvate?. Xenobiotica 18:12, pages 1389-1399.
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M. Åhlman, Å. Bergman, P. O. Darnerud, B. Egestad & J. Sjövall. (1986) Chlorinated paraffins: formation of sulphur-containing metabolites of polychlorohexadecane in rats. Xenobiotica 16:3, pages 225-232.
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A. R. Jones & G. Wells. (1981) The comparative metabolism of 2-bromoethanol and ethylene oxide in the rat. Xenobiotica 11:11, pages 763-770.
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Makoto Take, Tetsuya Takeuchi, Shigeyuki Hirai, Kenji Takanobu, Michiharu Matsumoto, Shoji Fukushima & Jun Kanno. (2017) Distribution of 1,2-dichloropropane in blood and other tissues of rats after oral administration. The Journal of Toxicological Sciences 42:2, pages 121-128.
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Yukie Yanagiba, Tetsuya Suzuki, Megumi Suda, Rieko Hojo, Frank J Gonzalez, Tamie Nakajima & Rui-Sheng Wang. (2016) Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage. Toxicology and Industrial Health 32:9, pages 1589-1597.
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Yu Toyoda, Tappei Takada & Hiroshi Suzuki. (2016) Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis. Scientific Reports 6:1.
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Andrea Trevisan, Paola Meneghetti, Stefano Maso & Ornella Troso. (2016) In-Vitro Mechanisms of 1,2-Dichloropropane Nephrotoxicity using the Renal Cortical Slice Model. Human & Experimental Toxicology 12:2, pages 117-121.
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B. Alex Merrick, Merrel Robinson & Lyman W. Condie. (2006) Cardiopathic effect of 1,2,3‐trichloropropane after subacute and subchronic exposure in rats. Journal of Applied Toxicology 11:3, pages 179-187.
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Charles Timchalk, Mark D. Dryzga, Fred A. Smith & Michael J. Bartels. (1991) Disposition and metabolism of [14C]1,2-dichloropropane following oral and inhalation exposure in Fischer 344 rats. Toxicology 68:3, pages 291-306.
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A. di Nucci, C. Gregotti, L. Manzo, M. Imbriani, S. Ghittori, L. Bianco, L. Maestri & E. Capodaglio. (2006) 1,2‐Dichloropropane hepatotoxicity in rats after inhalation exposure. Journal of Applied Toxicology 10:6, pages 391-394.
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R. Imberti, A. Mapelli, P. Colombo, P. Richelmi, F. Bertè & G. Bellomo. (1990) 1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH. Archives of Toxicology 64:6, pages 459-465.
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Andrea Trevisan, Enrico Rizzi, Antonio Scapinello, Francesco Gioffr� & Paolo Chiesura. (1989) Liver toxicity due to 1,2-dichloropropane in the rat. Archives of Toxicology 63:6, pages 445-449.
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A. Trevisan, E. Rizzi, G. Grandesso & P. Chiesura. (2016) 1-Chloro-2-hydroxypropane Epoxidase in Rat Liver and Other Organs. Human Toxicology 8:2, pages 163-163.
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Joop Hermens, Antoon Opperhuizen, Dirk T. H. M. Sijm, R. P. Wayne & B. L. WorobeyB. L. Worobey. 1989. Reactions and Processes. Reactions and Processes 57 110 .
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