Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 5
48
Views
74
CrossRef citations to date
0
Altmetric
Original Article

The metabolism and excretion of (+)-[14C]cyanidanol-3 in man following oral administration

, , &
Pages 279-286 | Received 05 Nov 1982, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Michael N. Clifford, Laurence J. King, Asimina Kerimi, Maria Gema Pereira-Caro & Gary Williamson. (2022) Metabolism of phenolics in coffee and plant-based foods by canonical pathways: an assessment of the role of fatty acid β-oxidation to generate biologically-active and -inactive intermediates. Critical Reviews in Food Science and Nutrition 0:0, pages 1-58.
Read now
Robert M Levy, Lakshmi Pillai & Bruce P Burnett. (2010) Nutritional benefits of flavocoxid in patients with osteoarthritis: efficacy and safety. Nutrition and Dietary Supplements 2, pages 27-38.
Read now
M.S. Fernandez-Panchon, D. Villano, A.M. Troncoso & M.C. Garcia-Parrilla. (2008) Antioxidant Activity of Phenolic Compounds: From In Vitro Results to In Vivo Evidence. Critical Reviews in Food Science and Nutrition 48:7, pages 649-671.
Read now
M. N. Clifford, E. L. Copeland, J. P. Bloxsidge & L. A. Mitchell. (2000) Hippuric acid as a major excretion product associated with black tea consumption. Xenobiotica 30:3, pages 317-326.
Read now
Kazuo OKUSHIO, Masayuki SUZUKI, Natsuki MATSUMOTO, Fumio NANJO & Yukihiko HARA. (1999) Methylation of Tea Catechins by Rat Liver Homogenates. Bioscience, Biotechnology, and Biochemistry 63:2, pages 430-432.
Read now
Tomomasa KANDA, Hiroshi AKIYAMA, Akio YANAGIDA, Masayuki TANABE, Yukihiro GODA, Masatake TOYODA, Reiko TESHIMA & Yukio SAITO. (1998) Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells. Bioscience, Biotechnology, and Biochemistry 62:7, pages 1284-1289.
Read now
Creina S. Stockley. (1998) Wine in moderation: How could and should recent in vitro and in vivo data be interpreted?. Drug and Alcohol Review 17:4, pages 365-376.
Read now
PeterC. H. Hollman, LilianB. M. Tijburg & ChungS. Yang. (1997) Bioavailability of flavonoids from tea. Critical Reviews in Food Science and Nutrition 37:8, pages 719-738.
Read now
G. Groenewoud & H. K. L. Hundt. (1986) The microbial metabolism of condensed (+)-catechins by rat-caecal microflora. Xenobiotica 16:2, pages 99-107.
Read now
A. M. Hackett, L. A. Griffiths & M. Wermeille. (1985) The quantitative disposition of 3-O-methyl-(+)-[U-14C]catechin in man following oral administration. Xenobiotica 15:11, pages 907-914.
Read now

Articles from other publishers (62)

Gary Williamson, Colin D. Kay & Alan Crozier. (2018) The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective. Comprehensive Reviews in Food Science and Food Safety 17:5, pages 1054-1112.
Crossref
Javier I. Ottaviani, Gina Borges, Tony Y. Momma, Jeremy P. E. Spencer, Carl L. Keen, Alan Crozier & Hagen Schroeter. (2016) The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives. Scientific Reports 6:1.
Crossref
Torsten Bohn. (2014) Dietary factors affecting polyphenol bioavailability. Nutrition Reviews 72:7, pages 429-452.
Crossref
Huadong Chen & Shengmin Sang. (2014) Biotransformation of tea polyphenols by gut microbiota. Journal of Functional Foods 7, pages 26-42.
Crossref
Wan Yong Feng. 2013. Tea in Health and Disease Prevention. Tea in Health and Disease Prevention 971 991 .
Wan Yong Feng. 2013. Tea in Health and Disease Prevention. Tea in Health and Disease Prevention 953 969 .
Cesar A. Lau-Cam. 2013. Chocolate in Health and Nutrition. Chocolate in Health and Nutrition 201 246 .
Martin de Bock, José G.B. Derraik & Wayne S. Cutfield. (2012) Polyphenols and Glucose Homeostasis in Humans. Journal of the Academy of Nutrition and Dietetics 112:6, pages 808-815.
Crossref
Javier I Ottaviani, Catherine Kwik-Uribe, Carl L Keen & Hagen Schroeter. (2012) Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. The American Journal of Clinical Nutrition 95:4, pages 851-858.
Crossref
Aida Serra, Alba Macià, Maria-Paz Romero, Josep Valls, Cinta Bladé, Lluís Arola & Maria-José Motilva. (2009) Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models . British Journal of Nutrition 103:7, pages 944-952.
Crossref
Jeremy P. E. Spencer, Manal M. Abd El Mohsen, Ann-Marie Minihane & John C. Mathers. (2007) Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. British Journal of Nutrition 99:1, pages 12-22.
Crossref
Gian Luigi Russo. (2007) Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochemical Pharmacology 74:4, pages 533-544.
Crossref
Tanja Grimm, Roswitha Skrabala, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdeňka Ďuračková & Petra Högger. (2006) Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers. BMC Clinical Pharmacology 6:1.
Crossref
D. Venkat Ratnam, D.D. Ankola, V. Bhardwaj, D.K. Sahana & M.N.V. Ravi Kumar. (2006) Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. Journal of Controlled Release 113:3, pages 189-207.
Crossref
Toshihiko Shoji, Saeko Masumoto, Nina Moriichi, Hiroshi Akiyama, Tomomasa Kanda, Yasuyuki Ohtake & Yukihiro Goda. (2006) Apple Procyanidin Oligomers Absorption in Rats after Oral Administration:  Analysis of Procyanidins in Plasma Using the Porter Method and High-Performance Liquid Chromatography/Tandem Mass Spectrometry. Journal of Agricultural and Food Chemistry 54:3, pages 884-892.
Crossref
Hagen SchroeterChristian HeissJan BalzerPetra KleinbongardCarl L. KeenNorman K. HollenbergHelmut SiesCatherine Kwik-UribeHarold H. SchmitzMalte Kelm. (2006) (–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proceedings of the National Academy of Sciences 103:4, pages 1024-1029.
Crossref
Claudine Manach, Gary Williamson, Christine Morand, Augustin Scalbert & Christian Rémésy. (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. The American Journal of Clinical Nutrition 81:1, pages 230S-242S.
Crossref
Elzbieta M. Kurowska & John A. Manthey. (2004) Hypolipidemic Effects and Absorption of Citrus Polymethoxylated Flavones in Hamsters with Diet-Induced Hypercholesterolemia. Journal of Agricultural and Food Chemistry 52:10, pages 2879-2886.
Crossref
W. M. Stöggl, C. W. Huck & Günther K. Bonn. (2004) Structural elucidation of catechin and epicatechin in sorrel leaf extracts using liquid-chromatography coupled to diode array-, fluorescence-, and mass spectrometric detection. Journal of Separation Science 27:7-8, pages 524-528.
Crossref
Thomas Walle. (2004) Absorption and metabolism of flavonoids. Free Radical Biology and Medicine 36:7, pages 829-837.
Crossref
Marie-Paule Gonthier, Jennifer L Donovan, Odile Texier, Catherine Felgines, Christian Remesy & Augustin Scalbert. (2003) Metabolism of dietary procyanidins in rats. Free Radical Biology and Medicine 35:8, pages 837-844.
Crossref
Gary D. Manners, Robert A. Jacob, Breksa, Thomas K. Schoch & Shin Hasegawa. (2003) Bioavailability of Citrus Limonoids in Humans. Journal of Agricultural and Food Chemistry 51:14, pages 4156-4161.
Crossref
Qingli Wu, Mingfu Wang & James E. Simon. (2003) Determination of Proanthocyanidins in Grape Products by Liquid Chromatography/Mass Spectrometric Detection under Low Collision Energy. Analytical Chemistry 75:10, pages 2440-2444.
Crossref
E.F Lhoste, V Ouriet, S Bruel, J.-P Flinois, C Brézillon, J Magdalou, C Chèze & L Nugon-Baudon. (2003) The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats. Food and Chemical Toxicology 41:5, pages 695-702.
Crossref
Susan E Ebeler, Charles A Brenneman, Gap-Soon Kim, William T Jewell, Michael R Webb, Leticia Chacon-Rodriguez, Emily A MacDonald, Amanda C Cramer, Andrew Levi, John D Ebeler, Alma Islas-Trejo, Amber Kraus, Steven H Hinrichs & Andrew J Clifford. (2002) Dietary catechin delays tumor onset in a transgenic mouse model,,. The American Journal of Clinical Nutrition 76:4, pages 865-872.
Crossref
Yoshinori Fujimura, Hirofumi Tachibana, Mari Maeda-Yamamoto, Toshio Miyase, Mitsuaki Sano & Koji Yamada. (2002) Antiallergic Tea Catechin, (−)-Epigallocatechin-3- O -(3- O -methyl)-gallate, Suppresses FcεRI Expression in Human Basophilic KU812 Cells . Journal of Agricultural and Food Chemistry 50:20, pages 5729-5734.
Crossref
Jennifer L. Donovan, Adam Lee, Claudine Manach, Laurent Rios, Christine Morand, Augustin Scalbert & Christian Rémésy. (2007) Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B 3 . British Journal of Nutrition 87:4, pages 299-306.
Crossref
Allison F. Wren, Michael Cleary, Christopher Frantz, Shawn Melton & Leslie Norris. (2002) 90-Day Oral Toxicity Study of a Grape Seed Extract (IH636) in Rats. Journal of Agricultural and Food Chemistry 50:7, pages 2180-2192.
Crossref
Jennifer L. Donovan, Sidika Kasim-Karakas, J. Bruce German & Andrew L. Waterhouse. (2007) Urinary excretion of catechin metabolites by human subjects after red wine consumption. British Journal of Nutrition 87:1, pages 31-37.
Crossref
Theo P.J. Mulder, Chris J. van Platerink, P.J. Wijnand Schuyl & Johan M.M. van Amelsvoort. (2001) Analysis of theaflavins in biological fluids using liquid chromatography–electrospray mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 760:2, pages 271-279.
Crossref
Jennifer L. Donovan, Vanessa Crespy, Claudine Manach, Christine Morand, Catherine Besson, Augustin Scalbert & Christian Rémésy. (2001) Catechin Is Metabolized by Both the Small Intestine and Liver of Rats. The Journal of Nutrition 131:6, pages 1753-1757.
Crossref
G.J Soleas, J Yan & D.M Goldberg. (2001) Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. Journal of Chromatography B: Biomedical Sciences and Applications 757:1, pages 161-172.
Crossref
George J. Soleas, Joe Yan & David M. Goldberg. 2001. Flavonoids and Other Polyphenols. Flavonoids and Other Polyphenols 130 145 .
C�cile Cren-Oliv�, St�phanie D�prez, St�phane Lebrun, Bernadette Coddeville & Christian Rolando. (2000) Characterization of methylation site of monomethylflavan-3-ols by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 14:23, pages 2312-2319.
Crossref
Masazumi Suzuki, Kyoji Yoshino, Mari Maeda-Yamamoto, Toshio Miyase & Mitsuaki Sano. (2000) Inhibitory Effects of Tea Catechins and O -Methylated Derivatives of (−)-Epigallocatechin-3- O -gallate on Mouse Type IV Allergy . Journal of Agricultural and Food Chemistry 48:11, pages 5649-5653.
Crossref
Dietrich Rein, Teresa G. Paglieroni, Debra A. Pearson, Ted Wun, Harold H. Schmitz, Robert Gosselin & Carl L. Keen. (2000) Cocoa and Wine Polyphenols Modulate Platelet Activation and Function. The Journal of Nutrition 130:8, pages 2120S-2126S.
Crossref
Augustin Scalbert & Gary Williamson. (2000) Dietary Intake and Bioavailability of Polyphenols. The Journal of Nutrition 130:8, pages 2073S-2085S.
Crossref
Dietrich Rein, Teresa G Paglieroni, Ted Wun, Debra A Pearson, Harold H Schmitz, Robert Gosselin & Carl L Keen. (2000) Cocoa inhibits platelet activation and function. The American Journal of Clinical Nutrition 72:1, pages 30-35.
Crossref
Andrea T. Borchers, Carl L. Keen, Sandra M. Hannum & M. Eric Gershwin. (2000) Cocoa and Chocolate: Composition, Bioavailability, and Health Implications. Journal of Medicinal Food 3:2, pages 77-105.
Crossref
Jennifer RC Bell, Jennifer L Donovan, Rodney Wong, Andrew L Waterhouse, J Bruce German, Rosemary L Walzem & Sidika E Kasim-Karakas. (2000) (+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine. The American Journal of Clinical Nutrition 71:1, pages 103-108.
Crossref
Jennifer L. Donovan, Jennifer R. Bell, Sidika Kasim-Karakas, J. Bruce German, Rosemary L. Walzem, Robert J. Hansen & Andrew L. Waterhouse. (1999) Catechin Is Present as Metabolites in Human Plasma after Consumption of Red Wine. The Journal of Nutrition 129:9, pages 1662-1668.
Crossref
Jennifer L Donovan, Devanand L Luthria, Phil Stremple & Andrew L Waterhouse. (1999) Analysis of (+)-catechin, (−)-epicatechin and their 3′- and 4′-O-methylated analogs. Journal of Chromatography B: Biomedical Sciences and Applications 726:1-2, pages 277-283.
Crossref
Debra A. Pearson, Christine H. Tan, J.Bruce German, Paul A. Davis & M.Eric Gershwin. (1999) Apple juice inhibits human low density lipoprotein oxidation. Life Sciences 64:21, pages 1913-1920.
Crossref
Yukiaki Kuroda & Yukihiko Hara. (1999) Antimutagenic and anticarcinogenic activity of tea polyphenols. Mutation Research/Reviews in Mutation Research 436:1, pages 69-97.
Crossref
Junji Terao. 1999. Antioxidant Food Supplements in Human Health. Antioxidant Food Supplements in Human Health 255 268 .
Stéphanie Déprez & Augustin Scalbert. 2000. Plant Polyphenols 2. Plant Polyphenols 2 357 370 .
KEVIN D. CROFT. (1998) The Chemistry and Biological Effects of Flavonoids and Phenolic Acidsa. Annals of the New York Academy of Sciences 854:1 TOWARDS PROLO, pages 435-442.
Crossref
A. T. Diplock, J.-L. Charuleux, G. Crozier-Willi, F. J. Kok, C. Rice-Evans, M. Roberfroid, W. Stahl & J. Viña-Ribes. (2007) Functional food science and defence against reactive oxidative species. British Journal of Nutrition 80:S1, pages S77-S112.
Crossref
Hironori Tsuchiya, Masaru Sato, Hirotsugu Kato, Hidetoshi Kureshiro & Nobuhiko Takagi. (1998) Nanoscale analysis of pharmacologically active catechins in body fluids by HPLC using borate complex extraction pretreatment. Talanta 46:4, pages 717-726.
Crossref
Mauro Serafini, Giuseppe Maiani & Anna Ferro-Luzzi. (1998) Alcohol-Free Red Wine Enhances Plasma Antioxidant Capacity in Humans. The Journal of Nutrition 128:6, pages 1003-1007.
Crossref
Edson L Da Silva, Mariusz Piskula & Junji Terao. (1998) Enhancement of Antioxidative Ability of Rat Plasma by Oral Administration of (−)-Epicatechin. Free Radical Biology and Medicine 24:7-8, pages 1209-1216.
Crossref
W.E Bronner & G.R Beecher. (1998) Method for determining the content of catechins in tea infusions by high-performance liquid chromatography. Journal of Chromatography A 805:1-2, pages 137-142.
Crossref
Stéphane Carando, Pierre-Louis Teissedre & Jean-Claude Cabanis. (1998) Comparison of (+)-catechin determination in human plasma by high-performance liquid chromatography with two types of detection: fluorescence and ultraviolet. Journal of Chromatography B: Biomedical Sciences and Applications 707:1-2, pages 195-201.
Crossref
Ruping Xu, Wallace H Yokoyama, Delilah Irving, Dietrich Rein, Rosemary L Walzem & J.Bruce German. (1998) Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters. Atherosclerosis 137:1, pages 29-36.
Crossref
Isabel Rayo Llerena & Emilio Marín Huerta. (1998) Vino y corazón. Revista Española de Cardiología 51:6, pages 435-449.
Crossref
Devanand L. Luthria, A. Daniel Jones, Jennifer L. Donovan & Andrew L. Waterhouse. (1997) GC-MS determination of catechin and epicatechin levels in human plasma. Journal of High Resolution Chromatography 20:11, pages 621-623.
Crossref
Isabel Hurtado, Pilar Caldú, Albert Gonzalo, Josep M. Ramon, Santiago Mínguez & Concepció Fiol. (1997) Antioxidative Capacity of Wine on Human LDL Oxidation in Vitro :  Effect of Skin Contact in Winemaking of White Wine . Journal of Agricultural and Food Chemistry 45:4, pages 1283-1289.
Crossref
Tibor Fuleki & Jorge M. Ricardo da Silva. (1997) Catechin and Procyanidin Composition of Seeds from Grape Cultivars Grown in Ontario. Journal of Agricultural and Food Chemistry 45:4, pages 1156-1160.
Crossref
Yih Ho, Yueh-Lin Lee & Kuang-Yang Hsu. (1995) Determination of (+)-catechin in plasma by high-performance liquid chromatography using fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications 665:2, pages 383-389.
Crossref
S H el-SharkawayM I SelimM S AfifiF T Halaweish. (1991) Microbial transformation of zearalenone to a zearalenone sulfate. Applied and Environmental Microbiology 57:2, pages 549-552.
Crossref
A R IbrahimY J Abul-Hajj. (1989) Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus. Applied and Environmental Microbiology 55:12, pages 3140-3142.
Crossref
M. V. Smillie, L. A. Griffiths, P. J. Male & M. M. Wermeille. (1987) The disposition and metabolism of (+)-cyanidanol-3 in patients with alcoholic cirrhosis. European Journal of Clinical Pharmacology 33:3, pages 255-259.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.