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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 9
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Original Article

Inhibition of antipyrine metabolite formation in rats in vivo

J. C. Rhodes Department of Pharmacy, University of Manchester, M13 9PLUK
,
S. T. Hall Department of Pharmacy, University of Manchester, M13 9PLUK
&
J. B. Houston Department of Pharmacy, University of Manchester, M13 9PLUK
Pages 677-686 | Received 21 Jul 1983, Published online: 30 Sep 2009

Citations (16)

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Read on this site (4)

Chaoqun Tan, Naiyun Gao, Yang Deng, Lei Li, Jing Deng & Shiqing Zhou. (2015) Kinetic oxidation of antipyrine in heat-activated persulfate. Desalination and Water Treatment 53:1, pages 263-271.
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S. K. Kuwahara, T. J. Shinn, B. D. Schreider, M. L. Phan & A. N. Kotake. (1995) Aminopyrine infusion breath test for the determination of changes in P450 metabolism in vivo. Xenobiotica 25:9, pages 973-980.
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Ripla Beri & Ramesh Chandra. (1993) Chemistry and Biology of Heme Effect of Metal Salts, Organometals, and Metalloporphyrins on Heme Synthesis and Catabolism, with Special Reference to Clinical Implications and Interactions with Cytochrome P-450. Drug Metabolism Reviews 25:1-2, pages 49-152.
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P. N. Shaw, S. T. Hall & J. B. Houston. (1986) Effect of pregnenolone carbonitrile, promethazine and antipyrine pretreatment on antipyrine metabolite formation in rats. Xenobiotica 16:12, pages 1109-1116.
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Articles from other publishers (12)

A Adedoyin, L Aarons & J B Houston. (1985) Plasma Concentration-Response Relationship for Cimetidine Inhibition of Drug Metabolism in the Rat. Journal of Pharmacy and Pharmacology 37:Supplement_12, pages 37P-37P.
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A Woolley, J Haslam & P N Shaw. (1985) Effects of Phenylbutazone and Oxyphenbutazone on Hepatic Drug Metabolism in the Rat. Journal of Pharmacy and Pharmacology 37:Supplement_12, pages 34P-34P.
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M. J. Eccles, T. C. Danbury, J. M. Ford & C. J. C. Roberts. (1997) The effect of velnacrine on the mixed function oxidase system. European Journal of Drug Metabolism and Pharmacokinetics 22:2, pages 121-125.
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I. Velic, M. Metzler, H.G. Hege & J. Weymann. (1995) Separation and identification of phase I and phase II [14C]antipyrine metabolites in rat and dog urine. Journal of Chromatography B: Biomedical Sciences and Applications 666:1, pages 139-147.
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Steffen Loft. (1990) Metronidazole and Antipyrine as Probes for the Study of Foreign Compound Metabolism. Pharmacology & Toxicology 66, pages 1-31.
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Richard A. Galbraith & Peter H. Jellinck. (1989) Differential effects of cimetidine, ranitidine and famotidine on the hepatic metabolism of estrogen and testosterone in male rats. Biochemical Pharmacology 38:12, pages 2046-2049.
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Steffen Loft & Henrik Enohusen Poulsen. (1989) Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Biochemical Pharmacology 38:7, pages 1125-1136.
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Richard A. Galbraith & Peter H. Jellinck. (1989) Decreased estrogen hydroxylation in male rat liver following cimetidine treatment. Biochemical Pharmacology 38:2, pages 313-319.
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J.Brian Houston, Michael J. Humphrey, Diana E. Matthew & Michael H. Tarbit. (1988) Comparison of two azole antifungal drugs, ketoconazole and fluconazole, as modifiers of rat hepatic monooxygenase activity. Biochemical Pharmacology 37:3, pages 401-408.
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P. Nicholas Shaw & J. Brian Houston. (1987) Kinetics of drug metabolism inhibition: Use of metabolite concentration-time profiles. Journal of Pharmacokinetics and Biopharmaceutics 15:5, pages 497-510.
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P.N. Shaw & J.B. Houston. (1986) Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats. Toxicology and Applied Pharmacology 84:2, pages 232-240.
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Porntip Buppodom, Nobuyuki Koga, Hideyuki Yamada & Hidetoshi Yoshimura. (1986) Studies on rat liver cytochrome P-450s involved in the metabolism of antipyrine: phenobarbital- and 3-methylcholanthrene-inducible isozymes possessing 4-hydroxylase activity. Biochemical Pharmacology 35:8, pages 1404-1406.
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