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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 9
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Original Article

The disposition of clavulanic acid in man

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Pages 853-863 | Received 03 Oct 1985, Published online: 30 Sep 2009

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David E Amacher. (2012) The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 8:3, pages 335-347.
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Peyman Esmaili‐Shahzade‐Ali‐Akbari, Amir Ghaderi, Seyyed Mohammad Mehdi Hosseini, Fatemeh Nejat, Maryam Saeedi‐Mofrad, Motahareh Karimi‐Houyeh, Alireza Ghattan, Amirreza Etemadi, Elham Rasoulian & Arina Khezri. (2023) β_lactam antibiotics against drug addiction: A novel therapeutic option. Drug Development Research 84:7, pages 1411-1426.
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Fleur M. Keij, Gerdien A. Tramper-Stranders, Birgit C. P. Koch, Irwin K. M. Reiss, Anouk E. Muller, René F. Kornelisse & Karel Allegaert. (2022) Pharmacokinetics of Clavulanic Acid in the Pediatric Population: A Systematic Literature Review. Clinical Pharmacokinetics 61:5, pages 637-653.
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Paula Viana, Leonor Meisel, Ana Lopes, Rosário de Jesus, Georgina Sarmento, Sofia Duarte, Bruno Sepodes, Ana Fernandes, Margarida M. Correia dos Santos, Anabela Almeida & M. Conceição Oliveira. (2021) Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study. Antibiotics 10:8, pages 888.
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Sînziana Cristea, Elke H. J. Krekels, Karel Allegaert, Peter De Paepe, Annick de Jaeger, Pieter De Cock & Catherijne A. J. Knibbe. (2021) Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3. The AAPS Journal 23:3.
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Anab Fatima, Mohammad Jiyad Shaikh, Hina Zahid, Ishart Younus, Sheikh Abdul Khaliq & Farah Khalid. 2019. Medicinal Chemistry. Medicinal Chemistry.
Ryan L. Crass & Manjunath P. Pai. (2019) Pharmacokinetics and Pharmacodynamics of β‐Lactamase Inhibitors. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 39:2, pages 182-195.
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C. Stephens, M.I. Lucena & R.J. Andrade. 2018. Comprehensive Toxicology. Comprehensive Toxicology 625 650 .
Alqassem Y. Hakami & Youssef Sari. (2017) β-Lactamase inhibitor, clavulanic acid, attenuates ethanol intake and increases glial glutamate transporters expression in alcohol preferring rats. Neuroscience Letters 657, pages 140-145.
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Jae Kim, Joel John, Dianne Langford, Ellen Walker, Sara Ward & Scott M. Rawls. (2015) Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. Amino Acids 48:3, pages 689-696.
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Joseph A. Schroeder, Nicholas G. Tolman, Faye F. McKenna, Kelly L. Watkins, Sara M. Passeri, Alexander H. Hsu, Brittany R. Shinn & Scott M. Rawls. (2014) Clavulanic acid reduces rewarding, hyperthermic and locomotor-sensitizing effects of morphine in rats: A new indication for an old drug?. Drug and Alcohol Dependence 142, pages 41-45.
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Ann K. Daly. (2012) Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions. Annual Review of Pharmacology and Toxicology 52:1, pages 21-35.
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S.M. Rawls, F. Karaca, I. Madhani, V. Bhojani, R.L. Martinez, M. Abou-Gharbia & R.B. Raffa. (2010) β-lactamase inhibitors display anti-seizure properties in an invertebrate assay. Neuroscience 169:4, pages 1800-1804.
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Akash Khandelwal, Praveen M. Bahadduri, Cheng Chang, James E. Polli, Peter W. Swaan & Sean Ekins. (2007) Computational Models to Assign Biopharmaceutics Drug Disposition Classification from Molecular Structure. Pharmaceutical Research 24:12, pages 2249-2262.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:9, pages 2031-2122.
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Gregory Moran. (2006) Approaches to treatment of community-acquired pneumonia in the Emergency Department and the appropriate role of fluoroquinolones. The Journal of Emergency Medicine 30:4, pages 377-387.
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Amparo S??nchez Navarro. (2005) New Formulations of Amoxicillin/Clavulanic Acid. Clinical Pharmacokinetics 44:11, pages 1097-1115.
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T. B. Vree, E. Dammers & E. Van Duuren. (2003) Variable absorption of clavulanic acid after an oral dose of 25 mg/kg of Clavubactin ® and Synulox ® in healthy dogs . Journal of Veterinary Pharmacology and Therapeutics 26:3, pages 165-171.
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Marc L. Hautekeete, Yves Horsmans, Christine van Waeyenberge, Christian Demanet, Jean Henrion, Louis Verbist, Reginald Brenard, Christine Sempoux, Peter P. Michielsen, Paul S.H. Yap, Jacques Rahier & Andre P. Geubel. (1999) HLA association of amoxicillin-clavulanate–induced hepatitis. Gastroenterology 117:5, pages 1181-1186.
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Keith H. Baggaley, Allan G. Brown & Christopher J. Schofield. (1997) Chemistry and biosynthesis of clavulanic acid and other clavams. Natural Product Reports 14:4, pages 309.
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J.P. Desager, J. Costermans, Y. Van Nieuwenhuyze & C. Harvengt. (2016) Oral Bioavailability of Ampicillin and Amoxycillin Alone and Bound in Fixed Proportions to Sulbactam and Clavulanic Acid. Journal of International Medical Research 17:6, pages 532-538.
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Marc Verhamme, Carlos Ramboer, Peter Van De Bruaene & Nirwan Inderadjaja. (1989) Cholestatic hepatitis due to an amoxycillin/clavulanic acid preparation. Journal of Hepatology 9:2, pages 260-264.
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BE Davies, R Boon, R Horton, FC Reubi & CE Descoeudres. (2012) Pharmacokinetics of amoxycillin and clavulanic acid in haemodialysis patients following intravenous administration of Augmentin.. British Journal of Clinical Pharmacology 26:4, pages 385-390.
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