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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 9
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Original Article

The disposition of clavulanic acid in man

G. C. Bolton Drug Metabolism and Pharmacokinetics Department, Beecham Pharmaceuticals Research Division, Coldharbour Road, The Pinnacles, Harlow Essex, CM19 5AD, UK
,
G. D. Allen Drug Metabolism and Pharmacokinetics Department, Beecham Pharmaceuticals Research Division, Coldharbour Road, The Pinnacles, Harlow Essex, CM19 5AD, UK
,
B. E. Davies Drug Metabolism and Pharmacokinetics Department, Beecham Pharmaceuticals Research Division, Coldharbour Road, The Pinnacles, Harlow Essex, CM19 5AD, UK
,
C. W. Filer Drug Metabolism and Pharmacokinetics Department, Beecham Pharmaceuticals Research Division, Coldharbour Road, The Pinnacles, Harlow Essex, CM19 5AD, UK
&
D. J. Jeffery Drug Metabolism and Pharmacokinetics Department, Beecham Pharmaceuticals Research Division, Coldharbour Road, The Pinnacles, Harlow Essex, CM19 5AD, UK
Pages 853-863 | Received 03 Oct 1985, Published online: 30 Sep 2009

References

  • Allen L., Kimura K., MacKichan J., Ritschel W. Manual of symbols, equations and definitions in pharmacokinetics. Journal of Clinical Pharmacology 1982; 22: 1–23S
  • Bolton G. C., Allen G. D., Filer C. W., Jeffery D. J. Absorption, metabolism and excretion studies on clavulanic acid in the rat and dog. Xenobiotica 1984; 14: 483–490
  • Brown A. G., Butterworth D., Cole M., Hanscomb G., Hood J. D., Reading C., Rolinson G. N. Naturally occurring beta lactamase inhibitors with bacterial activity. Journal of Antibiotics 1976; 29: 668–669
  • Byron P. R., Notari R. E. Critical analysis of ‘Flip Flop’ phenomenon in two-compartment pharmacokinetics model. Journal of Pharmaceutical Sciences 1976; 65: 1140–1144
  • Davies J. S., Howarth T. T. Clavulanic acid. Rearrangement to 3,4-disubstituted pyrroles. Tetrahedron Letters 1982; 23: 3109–3112
  • Davies B. E., Coates P. E., Clarke J. G. N., Thawley A. R., Sutton J. A. Bioavailability and pharmacokinetics of clavulanic acid in healthy subjects. International Journal of Clinical Pharmacology Therapy and Toxicology 1985; 23(2)70–73
  • Elson S. W., Oliver R. S. Studies on the biosynthesis of clavulanic acid. 1. Incorporation of 13C-labelled precursors. Journal of Antibiotics 1978; 31: 586–592
  • Gibaldi M., Perrier D. Pharmacokinetics. Marcel Dekker, New York 1982
  • Howarth T. T., Brown A. G., King T. J. Clavulanic acid, a novel β-lactam isolated from Streptomyces clavuligerus; X-ray crystal structure analysis. Journal of the Chemical Society, Chemical Communications 1976; D7: 266–267
  • Legg B., Clarke J. G. N., Davies B. E., Wadds G. A. Automated enzyme inhibition assay for clavulanic acid in biological samples. Journal of Pharmaceutical and Biomedical Analysis 1985; 3: 381–384
  • Reading C., Cole M. Clavulanic acid; a beta-lactamase inhibiting beta lactam from Streptomyces clavuligerus. Antimicrobial Agents Chemotherapy 1977; 11: 852–857
  • Riegelman S., Collier P. The application of Statistical Moment Theory to the evaluation of ‘in vivo’ dissolution time and absorption time. Journal of Pharmacokinetics and Biopharmaceutics 1980; 8: 509–534
  • Shaw W. A., Harlan W. R., Bennett A. Improved method for counting radioisotopes adsorbed on silica gel. Analytical Biochemistry 1971; 43: 119–122
  • Tagawa K., Kawate M., Goto S. Biopharmaceutical evaluation of gelatin microcapsules of several oral antibiotics. Chemical and Pharmaceutical Bulletin 1983; 31: 269–273
  • Tanigawara Y., Yamaoka K., Nakagawa T., Uno T. Moment analysis for the separation of mean ‘in vivo’ disintegration, dissolution, absorption and disposition time of ampicillin products. Journal of Pharmaceutical Sciences 1982; 71: 1129–1133

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