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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 9
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Original Article

Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidation

G. A. Moore Department of Toxicology, Karolinska Institutet, Box 60 400, S-104 01, Stockholm, Sweden
,
P. J. O'brien Department of Toxicology, Karolinska Institutet, Box 60 400, S-104 01, Stockholm, Sweden
&
S. Orrenius Department of Toxicology, Karolinska Institutet, Box 60 400, S-104 01, Stockholm, Sweden
Pages 873-882 | Received 24 Jan 1986, Published online: 30 Sep 2009

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T.R. Henry & K.B. Wallace. (1995) The Role of Redox Cycling versus Arylation in Quinone-Induced Mitochondrial Dysfunction: A Mechanistic Approach in Classifying Reactive Toxicants. SAR and QSAR in Environmental Research 4:2-3, pages 97-108.
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TalaR. Henry, LauraE. Solem & KendallB. Wallace. (1995) Channel‐specific induction of the cyclosporine a‐sensitive mitochondrial permeability transition by menadione. Journal of Toxicology and Environmental Health 45:4, pages 489-504.
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Articles from other publishers (37)

Vera V. Teplova, Alexey G. Kruglov, Leonid I. Kovalyov, Anna B. Nikiforova, Nadezhda I. Fedotcheva & John J. Lemasters. (2017) Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria. Journal of Bioenergetics and Biomembranes 49:3, pages 253-264.
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A. Al Maruf, O. Lee & P.J. O’Brien. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Stephen J. Ralph, Sara Rodríguez-Enríquez, Jiri Neuzil, Emma Saavedra & Rafael Moreno-Sánchez. (2010) The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy. Molecular Aspects of Medicine 31:2, pages 145-170.
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O. Lee & P.J. O’Brien. 2010. Comprehensive Toxicology. Comprehensive Toxicology 411 445 .
Alexey G. Kruglov, Ksenia B. Subbotina & Nils-Erik L. Saris. (2008) Redox-cycling compounds can cause the permeabilization of mitochondrial membranes by mechanisms other than ROS production. Free Radical Biology and Medicine 44:4, pages 646-656.
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Evgeny Denisov & Igor Afanas’ev. 2005. Oxidation and Antioxidants in Organic Chemistry and Biology. Oxidation and Antioxidants in Organic Chemistry and Biology 1 284 .
Alexandre Patenaude, M. R. Ven Murthy & Marc-Edouard Mirault. (2004) Mitochondrial Thioredoxin System. Journal of Biological Chemistry 279:26, pages 27302-27314.
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Wright Jones, Xia Li, Zhi-chao Qu, Laureta Perriott, Richard R Whitesell & James M May. (2002) Uptake, recycling, and antioxidant actions of α-lipoic acid in endothelial cells. Free Radical Biology and Medicine 33:1, pages 83-93.
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Philip J Jewess, James Higgins, Kate J Berry, Stephen R Moss, Adrian B Boogaard & Bhupinder P S Khambay. (2002) Herbicidal action of 2‐hydroxy‐3‐alkyl‐1,4‐naphthoquinones. Pest Management Science 58:3, pages 234-242.
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Susumu Itoh & Shoju Onishi. (2000) Developmental changes of vitamin K epoxidase and reductase activities involved in the vitamin K cycle in human liver. Early Human Development 57:1, pages 15-23.
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Muniswamy Madesh & Kunissery A Balasubramanian. (1998) Cyclosporin A inhibits oxidant and calcium stimulated phospholipase D activity in the rat intestinal mitochondria. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1389:3, pages 206-212.
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Mark J. Andrews, Michael J. Garle & Richard H. Clothier. (2020) Reduction of the New Tetrazolium Dye, Alamar Blue™, in Cultured Rat Hepatocytes and Liver Fractions. Alternatives to Laboratory Animals 25:6, pages 641-653.
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Peter-Christian Klöhn, Ulrich Brandt & Hans-Günter Neumann. (1999) 2‐Nitrosofluorene and N ‐hydroxy‐2‐aminofluorene react with the ubiquinone‐reduction center (center N) of the mitochondrial cytochrome bc 1 complex . FEBS Letters 389:3, pages 233-237.
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Nadja C. De Souza-Pinto, Anibal E. Vercesi & Maria E. Hoffmann. (1996) Mechanism of tetrahydroxy-1,4-quinone cytotoxicity: Involvement of Ca22+ and H2O2 in the impairment of DNA replication and mitochondrial function. Free Radical Biology and Medicine 20:5, pages 657-666.
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Winston A. Morgan. (2006) DNA single‐strand breakage in mammalian cells induced by redox cycling quinones in the absence of oxidative stress. Journal of Biochemical Toxicology 10:4, pages 227-232.
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Enrique Cadenas. (1995) Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism. Biochemical Pharmacology 49:2, pages 127-140.
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S. Vamvakas & U. K�ster. (1993) The nephrotoxin dichlorovinylcysteine induces expression of the protooncogenesC-fos andC-myc in LLC-PK1 cells?A comparative investigation with growth factors and 12-O-tetradecanoylphorbolacetate. Cell Biology and Toxicology 9:1, pages 1-13.
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Winston A. Morgan, John A. Hartley & Gerald M. Cohen. (1992) Quinone-induced DNA single strand breaks in rat hepatocytes and human chronic myelogenous leukaemic K562 cells. Biochemical Pharmacology 44:2, pages 215-221.
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George E.N. Kass, Pierluigi Nicotera & Sten Orrenius. 1992. Biological Oxidants: Generation and Injurious Consequences. Biological Oxidants: Generation and Injurious Consequences 133 156 .
Sten Orrenius, Mark J. Burkitt, George E. N. Kass, Jeannette M. Dypbukt & Pierluigi Nicotera. (1992) Calcium ions and oxidative cell injury. Annals of Neurology 32:S1, pages S33-S42.
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Michael J. MacDonald. (1991) Stimulation of insulin release from pancreatic islets by quinones. Bioscience Reports 11:3, pages 165-170.
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Frank A.M. Redegeld, Ralf M.W. Moison, Helma M. Barentsen, Andries Sj. Koster & Jan Noordhoek. (1990) Interaction with cellular ATP generating pathways mediates menadione-induced cytotoxicity in isolated rat hepatocytes. Archives of Biochemistry and Biophysics 280:1, pages 130-136.
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Sten Orrenius, George E.N. Kass, Steven K. Duddy & Pierluigi Nicotera. 1990. Biological Oxidation Systems. Biological Oxidation Systems 965 975 .
Peter F. Smith & Glenn F. Rush. 1990. Toxic Interactions. Toxic Interactions 87 114 .
Sten Orrenius. 1990. Free Radicals, Lipoproteins, and Membrane Lipids. Free Radicals, Lipoproteins, and Membrane Lipids 257 267 .
Luigi Atzori, Ian A. Cotgreave & Peter Moldéus. 1990. Selective Activation of Drugs by Redox Processes. Selective Activation of Drugs by Redox Processes 229 235 .
Frank A.M. Redegeld, Ralf M.W. Moison, Andries Sj. Koster & Jan Noordhoek. (1989) Alterations in energy status by menadione metabolism in hepatocytes isolated from fasted and fed rats. Archives of Biochemistry and Biophysics 273:1, pages 215-222.
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G LudewigS DograH Glatt. (1989) Genotoxicity of 1,4-benzoquinone and 1,4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells.. Environmental Health Perspectives 82, pages 223-228.
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Garth Powis. (1989) Free radical formation by antitumor quinones. Free Radical Biology and Medicine 6:1, pages 63-101.
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Anders Brunmark & Enrique Cadenas. (1989) Redox and addition chemistry of quinoid compounds and its biological implications. Free Radical Biology and Medicine 7:4, pages 435-477.
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Sten Orrenius, David J. McConkey & Pierluigi Nicotera. 1989. Cell Calcium Metabolism. Cell Calcium Metabolism 451 461 .
Gregory A. Moore, Marianne Weis, Sten Orrenius & P.J. O'Brien. (1988) Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria. Archives of Biochemistry and Biophysics 267:2, pages 539-550.
Crossref
Anders Brunmark & Enrique Cadenas. (1988) Reductive addition of glutathione to p-benzoquinone, 2-hydroxy-p-benzoquinone, and p-benzoquinone epoxides. Effect of the hydroxy- and glutathionyl substituents on p-benzohydroquinone autoxidation. Chemico-Biological Interactions 68:3-4, pages 273-298.
Crossref
Gregory A. Moore, Luisa Rossi, Pierluigi Nicotera, Sten Orrenius & Peter J. O'Brien. (1987) Quinone toxicity in hepatocytes: Studies on mitochondrial Ca2+ release induced by benzoquinone derivatives. Archives of Biochemistry and Biophysics 259:2, pages 283-295.
Crossref
Gregory A. Moore, David J. McConkey, Georges E.N. Kass, Peter J. O'Brien & Sten Orrenius. (1987) 2,5-Di( tert -butyl)-1,4-benzohydroquinone - a novel inhibitor of liver microsomal Ca 2+ sequestration . FEBS Letters 224:2, pages 331-336.
Crossref
Peter F. Smith, David W. Alberts & Glenn F. Rush. (1987) Role of glutathione reductase during menadione-induced nadph oxidation in isolated rat hepatocytes. Biochemical Pharmacology 36:22, pages 3879-3884.
Crossref
Garth Powis. (1987) Metabolism and reactions of quinoid anticancer agents. Pharmacology & Therapeutics 35:1-2, pages 57-162.
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