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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

Cytotoxic drug penetration studies in multicellular tumour spheroids

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Pages 641-648 | Published online: 30 Sep 2009

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Andrew I. Minchinton, Karen R. Wendt, Kathy A. Clow & Karen H. Fryer. (1997) Multilayers of Cells Growing on a Permeable Support: An in Vitro Tumour Model. Acta Oncologica 36:1, pages 13-16.
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Julian M. Rozenberg, Gleb I. Filkov, Alexander V. Trofimenko, Evgeny A. Karpulevich, Vladimir D. Parshin, Valery V. Royuk, Marina I. Sekacheva & Mikhail O. Durymanov. (2021) Biomedical Applications of Non-Small Cell Lung Cancer Spheroids. Frontiers in Oncology 11.
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Danielle J. LaValley, Paula G. Miller & Michael L. Shuler. (2020) Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity . Biotechnology Progress 37:2.
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Eshita Khera, Cornelius Cilliers, Michael D. Smith, Michelle L. Ganno, Katharine C. Lai, Thomas A. Keating, Anna Kopp, Ian Nessler, Adnan O. Abu-Yousif & Greg M. Thurber. (2021) Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping. Neoplasia 23:2, pages 210-221.
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Aragaw Gebeyehu, Sunil Kumar Surapaneni, John Huang, Arindam Mondal, Vivian Ziwen Wang, Nana Fatima Haruna, Arvind Bagde, Peggy Arthur, Shallu Kutlehria, Nil Patel, Arun K. Rishi & Mandip Singh. (2021) Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening. Scientific Reports 11:1.
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Bishnubrata Patra, Julie Lafontaine, Maeva Bavoux, Karim Zerouali, Audrey Glory, Mohsen Ahanj, Jean-François Carrier, Thomas Gervais & Philip Wong. (2019) On-chip combined radiotherapy and chemotherapy testing on soft-tissue sarcoma spheroids to study cell death using flow cytometry and clonogenic assay. Scientific Reports 9:1.
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Vivek Kaushik, Juan Sebastian Yakisich, Yogesh Kulkarni, Neelam Azad & Anand Krishnan V. Iyer. 2018. Lung Cancer - Strategies for Diagnosis and Treatment. Lung Cancer - Strategies for Diagnosis and Treatment.
Darren Rodenhizer, Teresa Dean, Elisa D'Arcangelo & Alison P. McGuigan. (2018) The Current Landscape of 3D In Vitro Tumor Models: What Cancer Hallmarks Are Accessible for Drug Discovery?. Advanced Healthcare Materials 7:8, pages 1701174.
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. (2017) Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors. Journal of Biomedical Optics 22:11, pages 1.
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Ekaterina Schreiber-Brynzak, Verena Pichler, Petra Heffeter, Buck Hanson, Sarah Theiner, Irene Lichtscheidl-Schultz, Christoph Kornauth, Luca Bamonti, Vineet Dhery, Diana Groza, David Berry, Walter Berger, Mathea S Galanski, Michael A Jakupec & Bernhard K Keppler. (2016) Behavior of platinum( iv ) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation . Metallomics 8:4, pages 422-433.
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Marvin Schober, Ralf Jesenofsky, Ralf Faissner, Cornelius Weidenauer, Wolfgang Hagmann, Patrick Michl, Rainer Heuchel, Stephan Haas & J.-Matthias Löhr. (2014) Desmoplasia and Chemoresistance in Pancreatic Cancer. Cancers 6:4, pages 2137-2154.
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Can Sarisozen, Abraham H. Abouzeid & Vladimir P. Torchilin. (2014) The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors. European Journal of Pharmaceutics and Biopharmaceutics 88:2, pages 539-550.
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Geeta Mehta, Amy Y. Hsiao, Marylou Ingram, Gary D. Luker & Shuichi Takayama. (2012) Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. Journal of Controlled Release 164:2, pages 192-204.
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Andrew I. Minchinton & Alastair H. Kyle. 2010. Tumor Microenvironment. Tumor Microenvironment 329 352 .
Tae-Hee Kim, Christopher W. Mount, Wayne R. Gombotz & Suzie H. Pun. (2010) The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. Biomaterials 31:28, pages 7386-7397.
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Andrew I. Minchinton & Ian F. Tannock. (2006) Drug penetration in solid tumours. Nature Reviews Cancer 6:8, pages 583-592.
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E.S. Norris, J.R. King & H.M. Byrne. (2006) Modelling the response of spatially structured tumours to chemotherapy: Drug kinetics. Mathematical and Computer Modelling 43:7-8, pages 820-837.
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Ferdy J. Lejeune. (2006) Improving drug penetration in tumors by targeting tumor vascularization. Targeted Oncology 1:2, pages 90-96.
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M. Wartenberg, F. Dönmez, P. Budde & H. Sauer. 2006. Stem Cells. Stem Cells 53 71 .
J.P. Burgués Gasión, J.L. Pontones Moreno, C.D. Vera Donoso, J.F. Jiménez Cruz & M. Ozonas Moragues. (2005) Mecanismos del ciclo celular y la apoptosis implicados en las resistencias a los fármacos de uso intravesical en el cáncer superficial de vejiga. Actas Urológicas Españolas 29:9, pages 846-859.
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J. Walker, C. Martin & R. Callaghan. (2004) Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy. European Journal of Cancer 40:4, pages 594-605.
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Matthew D. Hall, Catherine Martin, David J.P. Ferguson, Roger M. Phillips, Trevor W. Hambley & Richard Callaghan. (2004) Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models. Biochemical Pharmacology 67:1, pages 17-30.
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John P. Ward & John R. King. (2003) Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures. Mathematical Biosciences 181:2, pages 177-207.
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Martin Erlanson, Erika Daniel-Szolgay & J�rgen Carlsson. (1992) Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids. Cancer Chemotherapy and Pharmacology 29:5, pages 343-353.
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Rosalyn D. Blumenthal, Irwin Fand, Robert M. Sharkey, Otto C. Boerman, Rina Kashi & David M. Goldenberg. (1991) The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies: An autoradiographic study. Cancer Immunology Immunotherapy 33:6, pages 351-358.
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Larry M. Weisenthal. 1991. Human Cancer in Primary Culture, A Handbook. Human Cancer in Primary Culture, A Handbook 103 147 .
Ralph E. Durand. (1990) Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage?. Cancer Chemotherapy and Pharmacology 26:3, pages 198-204.
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Jörgen Carlsson & Thore Nederman. (1989) Tumour spheroid technology in cancer therapy research. European Journal of Cancer and Clinical Oncology 25:8, pages 1127-1133.
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