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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

Cytotoxic drug penetration studies in multicellular tumour spheroids

David J. Kerr Department of Medical Oncology, University of Glasgow, 1 Horslethill Road, Glasgow, G12 9LX, UK
,
Thomas E. Wheldon Department of Medical Oncology, University of Glasgow, 1 Horslethill Road, Glasgow, G12 9LX, UK; Radiobiology Group, Belvidere Hospital, Glasgow, UK
,
Sharyn Hydns Department of Medical Oncology, University of Glasgow, 1 Horslethill Road, Glasgow, G12 9LX, UK; Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
&
Stanley B. Kaye Department of Medical Oncology, University of Glasgow, 1 Horslethill Road, Glasgow, G12 9LX, UK
Pages 641-648 | Published online: 30 Sep 2009

References

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  • Kerr D. J., Kerr A. M., Freshney R. I., Kaye S. B. Comparative intracellular uptake of adriamycin and 4′-deoxydoxorubicin by non-small cell lung tumour cells in culture and its relationship to cell survival. Biochemical Pharmacology 1986; 35(16)2817–2832
  • Sutherland R. M., Eddy H. A., Barham B., Reich K., Vanantwerp D. Resistance to adriamycin in multicellular spheroids. International Journal of Radiation Oncology Biological Physics 1979; 5: 1225–1230
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  • Wibe E. Resistance to vincristine of human cells grown as multicellular spheroids. British Journal of Cancer 1980; 42: 937–941
  • Yuhas J. M., Li A. P., Martinez A. O., Lodman A. J. A simplified method for production and growth of multicellular tumour spheroids. Cancer Research 1977; 37: 3634–3643

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