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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

Use of hepatocyte cultures for preliminary metabolism and cytotoxicity studies of a new anti-hypertensive agent, oxaminozoline

A. Guillouzo Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France
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L. Grislain Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France; Technologie Servier, 45000, Orléans, France
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D. Ratanasavanh Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France
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M. T. Mocquard Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France; Technologie Servier, 45000, Orléans, France
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J-M. Begue Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France
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P. Du Vignaud Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France; Technologie Servier, 45000, Orléans, France
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N. Bromet Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France
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P. Genissel Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France; Institut de Recherches Internationales Servier, 92210, Neuilly sur Seine, France
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B. Beau Unité de Recherches, Hépatologiques U 49 de l'INSERM, Hôpital, de Pontchaillou, 35033, Rennes, Cédex, France; Institut de Recherches Internationales Servier, 92210, Neuilly sur Seine, France
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Pages 757-763 | Published online: 30 Sep 2009

Citations (5)

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C. Guguen-Guillouzo, P. Gripon, Y. Vandenberghe, F. Lamballe, D. Ratanasavanh & A. Guillouzo. (1988) Hepatotoxicity and molecular aspects of hepatocyte function in primary culture. Xenobiotica 18:6, pages 773-783.
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D. Ratanasavanh, G. Baffet, M. F. Latinier, M. Rissel & A. Guillouzo. (1988) Use of hepatocyte co-cultures in the assessment of drug toxicity from chronic exposure. Xenobiotica 18:6, pages 765-771.
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Articles from other publishers (3)

. 2001. Metabolic Maps. Metabolic Maps 288 295 .
May Akrawi, Vera Rogiers, Yves Vandenberghe, Colin N.A. Palmer, Antoine Vercruysse, Elizabeth A. Shephard & Ian R. Phillips. (1993) Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase. Biochemical Pharmacology 45:8, pages 1583-1591.
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Vera Rogiers, Yves Vandenberghe, André Callaerts, Gino Verleye, Miranda Cornet, Karine Mertens, Walter Sonck & Antoine Vercruysse. (1990) Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes. Biochemical Pharmacology 40:8, pages 1701-1706.
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