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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

Use of hepatocyte cultures for preliminary metabolism and cytotoxicity studies of a new anti-hypertensive agent, oxaminozoline

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Pages 757-763 | Published online: 30 Sep 2009

References

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  • Bégué J. M., Guguen-Guillouzo C., Pasdeloup N., Guillouzo A. Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type. Hepatology 1984; 4: 839–842
  • Grisham J. W. Use of hepatic cell cultures to detect and evaluate the mechanisms of action of toxic chemicals. International Review of Experimental Pathology 1979; 20: 123–210
  • Guguen C., Guillouzo A., Boisnard M., Le Cam A., Bourel M. Etude ultrastructurale de monocouches d'hépatocytes de rat adulte cultivés en présence d'hémisuccinate d'hydrocortisone. Biologie et Gastroentérologie 1975; 8: 223–231
  • Guguen-Guillouzo C. Role of homotypic and heterotypic cell interactions in expression of specific functions by cultured hepatocytes. Isolated and Cultured Hepatocytes, A. Guillouzo, C. Guguen-Guillouzo. INSERM, John Libbey, Paris, London 1986; 259–283
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  • Guillouzo A. Use of isolated and cultured hepatocytes for xenobiotic metabolism and cytotoxicity studies. Isolated and Cultured Hepatocytes, A. Guillouzo, C. Guguen-Guillouzo. INSERM, John Libbey, Paris, London 1986; 313–331
  • Laubie M., Poignant J. C., Scuvée-Moreau J., Dabire M., Dresse A., Schmitt H. Pharmacological properties of (N-dicyclopropylmethyl) amino-2-oxazoline S-3341, an α2 adrenoreceptor agonist. Journal de Pharmacologie (Paris) 1985; 16: 259–278
  • Ratanasavanh D., Baffet G., Latinier M. F., Rissel M., Guillouzo A. Use of hepatocyte co-cultures in the assessment of drug toxicity from chronic exposure. Xenobiotica 1988; 18: 765–771
  • Sirica A. E., Pitot H. C. Drug metabolism and effects of carcinogens in cultured hepatic cells. Pharmacological Reviews 1980; 31: 205–228
  • Van Zwieten P. A., Thoolen M. J. M. C., Jonkman P. A. M., Wilssert B., De Jong A., Timmermans P. B. N. W. M. Central and peripheral effects of S-3341 ‘(N-dicyclopropylmetriyl)-amino-2-oxazoline)’ in animal models. Archives Internationales de Pharmalogie et de Therapie 1986; 279: 130–149

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