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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

Use of hepatocyte co-cultures in the assessment of drug toxicity from chronic exposure

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Pages 765-771 | Published online: 30 Sep 2009

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André Guillouzo & Christiane Guguen-Guillouzo. (2008) Evolving concepts in liver tissue modeling and implications for in vitro toxicology. Expert Opinion on Drug Metabolism & Toxicology 4:10, pages 1279-1294.
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A. Guillouzo, L. Grislain, D. Ratanasavanh, M. T. Mocquard, J-M. Begue, P. Du Vignaud, N. Bromet, P. Genissel & B. Beau. (1988) Use of hepatocyte cultures for preliminary metabolism and cytotoxicity studies of a new anti-hypertensive agent, oxaminozoline. Xenobiotica 18:6, pages 757-763.
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Articles from other publishers (26)

Mauro Montalbano, Giuseppe Curcurù, Ali Shirafkan, Renza Vento, Cristiana Rastellini & Luca Cicalese. (2016) Modeling of Hepatocytes Proliferation Isolated from Proximal and Distal Zones from Human Hepatocellular Carcinoma Lesion. PLOS ONE 11:4, pages e0153613.
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Young Hee Kim & Jin Seok Kang. (2013) Expression of Glypican-3 in Mouse Embryo Stem Cells and its Derived Hepatic Lineage Cells Treated with Diethylnitrosamine in vitro. Asian Pacific Journal of Cancer Prevention 14:11, pages 6341-6345.
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Seok-Jin Kang, Sang-Hee Jeong, Eun-Joo Kim, Joon-Hyoung Cho, Young-Il Park, Sung-Won Park, Hyo-Sook Shin, Seong-Wan Son & Hwan-Goo Kang. (2012) Evaluation of hepatotoxicity of chemicals using hepatic progenitor and hepatocyte-like cells derived from mouse embryonic stem cells. Cell Biology and Toxicology 29:1, pages 1-11.
Crossref
. 2010. Drug Safety Evaluation. Drug Safety Evaluation 788 860 .
. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 73 .
Christiane Guguen-Guillouzo & Andre Guillouzo. 2010. Hepatocytes. Hepatocytes 1 40 .
Dirk Pleimes, Michael Pfaff, Christian Grosse-Siestrup, Gustav Schäcke, Volker Unger, Miriam Molliné, Renate Wrbitzky & David A. Groneberg. (2014) Lebertoxizität — molekulare Analyse von Leberfunktionsstörungen in der Arbeitsmedizin und UmweltmedizinLiver toxicity and molecular analysisToxicité hépatique et analyse moléculaire. Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie 57:3, pages 58-65.
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Konstantinos J Dabos, John A Parkinson, Leonard J Nelson, Ian H Sadler, Peter C Hayes & John N Plevris. (2003) The effect of hypothermia on primary porcine hepatocyte metabolism monitored by (1H) nuclear magnetic resonance spectroscopy. European Journal of Gastroenterology & Hepatology 15:3, pages 283-293.
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David A. Groneberg, Christian Grosse-Siestrup & Axel Fischer. (2016) In Vitro Models to Study Hepatotoxicity. Toxicologic Pathology 30:3, pages 394-399.
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T.M Walker, P.C Rhodes & C Westmoreland. (2000) The differential cytotoxicity of methotrexate in rat hepatocyte monolayer and spheroid cultures. Toxicology in Vitro 14:5, pages 475-485.
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Martínez‐Larrañaga, Anadón, Fernandez‐Cruz, Díaz, Martinez, Frejo, Martínez & Tafur. (2008) Cytotoxicity in pig hepatocytes induced by 8‐quinolinol, chloramine‐T and natamycin. Journal of Veterinary Pharmacology and Therapeutics 23:1, pages 37-44.
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Nafissa Rakba, Ahmed Melhaoui, Pascal Loyer, Jean Guy Delcros, Isabelle Morel & Gérard Lescoat. (1999) Bgugaine, a pyrrolidine alkaloid from Arisarum vulgare, is a strong hepatotoxin in rat and human liver cell cultures. Toxicology Letters 104:3, pages 239-248.
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A Guillouzo. (1998) Liver cell models in in vitro toxicology.. Environmental Health Perspectives 106:suppl 2, pages 511-532.
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. (2016) 9. In Vitro Strategies for Predicting Biokinetics and Systemic Toxicity. Human & Experimental Toxicology 16:1_suppl, pages 33-40.
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André Guillouzo, Fabrice Morel, Sophie Langouët, Karine Maheo & Maryvonne Rissel. (1997) Use of hepatocyte cultures for the study of hepatotoxic compounds. Journal of Hepatology 26, pages 73-80.
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D. Ratanasavanh, D. Lamiable, M. Biour, Y. Guédès, M. Gersberg, E. Leutenegger & C. Riché. (2009) Metabolism and toxicity of coumarin on cultured human, rat, mouse and rabbit hepatocytes. Fundamental & Clinical Pharmacology 10:6, pages 504-510.
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Roger G. Ulrich, James A. Bacon, Clay T. Cramer, Geoffrey W. Peng, Diane K. Petrella, Ronald P. Stryd & Elena L. Sun. (1995) Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development. Toxicology Letters 82-83, pages 107-115.
Crossref
C. Massart, J. Glbassler, F. Le Gall, M. L. Raoul, F. Beurtin, N. Genetet, B. Genetet & C. Lucas. (2008) Thyroid cell survival in coculture with autologous peripheral or intrathyroidal lymphocytes. Clinical Endocrinology 42:4, pages 379-387.
Crossref
Andreas Langner. (2006) Ersatz‐ und Ergänzungsmethoden zur Untersuchung der Biotransformation von Arzneistoffen. Pharmazie in unserer Zeit 24:4, pages 207-218.
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Brian A. Naughton, Benson Sibanda, Julia San Román & Gail K. Naughton. 1994. Alternatives to Animal Testing. Alternatives to Animal Testing 147 157 .
C. Legrand, J.M. Bour, C. Jacob, J. Capiaumont, A. Martial, A. Marc, M. Wudtke, G. Kretzmer, C. Demangel, D. Duval & J. Hache. (1992) Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cells as marker. Journal of Biotechnology 25:3, pages 231-243.
Crossref
Erik Walum, Michael BallsVera Bianchi, Bas Blaauboer, George Bolcsfoldi, Andre Guillouzo, Gregory A. Moore, Lena Odland, Christoph Reinhardt & Horst Spielmann. (2020) ECITTS: An Integrated Approach to the Application of In Vitro Test Systems to the Hazard Assessment of Chemicals, . Alternatives to Laboratory Animals 20:3, pages 406-428.
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Kazuhiko Otoguro, Kanki Komiyama, Satoshi Ωmura & Charles A. Tyson. (2020) An In Vitro Cytotoxicity Assay Using Rat Hepatocytes and MTT and Coomassie Blue Dye as Indicators . Alternatives to Laboratory Animals 19:3, pages 352-360.
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L.A.P. Hoogenboom, M.B.M. Oorsprong, T. van Vliet & H.A. Kuiper. (1991) The use of pig hepatocytes for cytotoxicity studies of veterinary drugs: A comparative study with furazolidone and other nitrofurans. Toxicology in Vitro 5:1, pages 31-38.
Crossref
A. Guillouzo, F. Morel, D. Ratanasavanh, C. Chesne & C. Guguen-Guillouzo. (1990) Long-term culture of functional hepatocytes. Toxicology in Vitro 4:4-5, pages 415-427.
Crossref
Marie A. Le Bot, Jean M. Bégué, Dominique Kernaleguen, Jacques Robert, Damrong Ratanasavanh, Jacques Airiau, Christian Riché & André Guillouzo. (1988) Different cytotoxicity and metabolism of doxorubicin, daunorubicin, epirubicin, esorubicin and idarubicin in cultured human and rat hepatocytes. Biochemical Pharmacology 37:20, pages 3877-3887.
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