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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

Use of hepatocyte co-cultures in the assessment of drug toxicity from chronic exposure

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Pages 765-771 | Published online: 30 Sep 2009

References

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  • Bégué J. M., Le Bigot J. F., Guguen-Guillouzo C., Kiechel J. R., Guillouzo A. Cultured human adult hepatocytes: a new model for drug metabolism studies. Biochemical Pharmacology 1983; 32: 1643–1646
  • Guguen-Guillouzo C. Role of homotypic and heterotypic cell interactions in expression of specific functions by cultured hepatocytes. Isolated and Cultured Hepatocytes, A. Guillouzo, C. Guguen-Guillouzo. Les Editions INSERM & John Libbey, Paris, London 1986; 259–283
  • Guguen-Guillouzo C., Campion J. P., Brissot P., Glaise D., Launois B., Bourel M., Guillouzo A. High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver. Cell Biology International Reports 1982; 6: 625–628
  • Guguen-Guillouzo C., Clément B., Baffet G., Beaumont C., Morel-Chany E., Glaise D., Guillouzo A. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Experimental Cell Research 1983; 143: 47–54
  • Guguen-Guillouzo C., Guillouzo A. Modulation of functional activities in cultured rat hepatocytes. Molecular and Cellular Biochemistry 1983; 53/54: 35–56
  • Guillouzo A. Use of isolated and cultured hepatocytes for xenobiotic metabolism and cytoxicity studies. Isolated and Cultured Hepatocytes, A. Guillouzo, C. Guguen-Guillouzo. Les Editions INSERM & John Libbey, Paris, London 1986; 313–331
  • Guillouzo A., Grislain L., Ratanasavanh D., Mocquard M. T., Bégué J. M., Du Vignaud P., Bromet N., Genissel P., Beau B. Use of hepatocyte cultures for preliminary metabolism and cytotoxicity studies of a new anti-hypertensive agent, oxaminozoline. Xenobiotica 1988; 18: 757–763
  • Vonen B., Morland J. Isolated rat hepatocytes in suspension: potential hepatoxic effects of six different drugs. Archives of Toxicology 1984; 56: 33–37

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