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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 8
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Original Article

Influence of medium composition on 7-alkoxycoumarin O-dealkylase activities of rat hepatocytes in primary maintenance culture

Maxine Warren Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
&
Jeffrey R. Fry Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
Pages 973-981 | Received 30 Jun 1987, Accepted 01 Dec 1987, Published online: 30 Sep 2009

Citations (17)

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Y. Nishibe & M. Hirata. (1993) Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes. Xenobiotica 23:6, pages 681-692.
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Articles from other publishers (16)

Michael Sinz. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 401 424 .
Lisheng Wang, Junhong Sun, Li Li, Douglas Mears, Margret Horvat & AG Ross Sheil. (2017) Comparison of Porcine Hepatocytes with Human Hepatoma (C3A) Cells for Use in a Bioartificial Liver Support System. Cell Transplantation 7:5, pages 459-468.
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G. Catapano. (2018) Mass Transfer Limitations to the Performance of Membrane Bioartificial Liver Support Devices. The International Journal of Artificial Organs 19:1, pages 18-35.
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Alison H. Hammond & Jeffrey R. Fry. (1994) Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time. Toxicology Letters 70:3, pages 337-342.
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Scott L. Nyberg, Madhusudan V. Peshwa, William D. Payne, Wei-Shou Hu & Frank B. Cerra. (1993) Evolution of the bioartificial liver: The need for randomized clinical trials. The American Journal of Surgery 166:5, pages 512-521.
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C. Guery, J.P. Stepniewski, B. Vannier, R. Fournex & G. Lorenzon. (1993) Long-term culture of rat hepatocytes on porous membranes in hormonally defined serum-free medium. Toxicology in Vitro 7:4, pages 453-459.
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Scott L. Nyberg, Russel A. Shatford, Madhusudan V. Peshwa, James G. White, Frank B. Cerra & Wei‐Shou Hu. (2004) Evaluation of a hepatocyte‐entrapment hollow fiber bioreactor: A potential bioartificial liver. Biotechnology and Bioengineering 41:2, pages 194-203.
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Juliet O. Lobo, Roxanne L. Samrock, David W. Jayme & Paul J. Price. 1993. Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects 195 201 .
Alison H. Hammond & Jeffrey R. Fry. (1992) Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes. Biochemical Pharmacology 44:7, pages 1461-1464.
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Evelynn A. Blankson, Richard J. Chenery & Alan J. Paine. (1991) Cytochrome P450 maintenance and diazepam metabolism in cultured rat hepatocytes. Biochemical Pharmacology 42:6, pages 1241-1245.
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A.H. Hammond & J.R. Fry. (1991) The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome P-450-mediated cytotoxicity. Toxicology in Vitro 5:2, pages 133-137.
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Vera Rogiers, Yves Vandenberghe, André Callaerts, Gino Verleye, Miranda Cornet, Karine Mertens, Walter Sonck & Antoine Vercruysse. (1990) Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes. Biochemical Pharmacology 40:8, pages 1701-1706.
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Alison H. Hammond & Jeffrey R. Fry. (1990) The in vivo induction of rat hepatic cytochrome P450-dependent enzyme activities and their maintenance in culture. Biochemical Pharmacology 40:3, pages 637-642.
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M.Teresa Donato, M.José Gómez-Lechón & JoséV. Castell. (1990) Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes. Biochemical Pharmacology 39:8, pages 1321-1326.
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J.R. Fry, M.J. Garle & A.H. Hammond. (1990) Competing pathways in metabolism-mediated cytotoxicity in vitro. Toxicology in Vitro 4:4-5, pages 467-473.
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Jeffrey R. Fry, Michael J. Garle & Alison H. Hammond. (2020) The Detection of Reactive Metabolites Generated by the Microsomal Mixed Function Oxidase System. Alternatives to Laboratory Animals 16:1, pages 8-13.
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