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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 2
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Original Article

N-oxygenation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent: The role of flavin-containing monooxygenase

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Pages 143-150 | Received 15 Jan 1988, Accepted 01 Sep 1988, Published online: 30 Sep 2009

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Milan Stefek, Ivana Milackova, Maria Juskova-Karasova & Vladimir Snirc. (2013) Antioxidant action of the hexahydropyridoindole SMe1EC2 in the cellular system of isolated red blood cells in vitro. Redox Report 18:2, pages 71-75.
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Agnieszka Augustyniak, Grzegorz Bartosz, Ana Čipak, Gunars Duburs, L'Ubica Horáková, Wojciech Łuczaj, Magdalena Majekova, Andreani D. Odysseos, Lucia Rackova, Elżbieta Skrzydlewska, Milan Stefek, Miriam Štrosová, Gunars Tirzitis, Petras Rimantas Venskutonis, Jana Viskupicova, Panagiota S. Vraka & Neven Žarković. (2010) Natural and synthetic antioxidants: An updated overview. Free Radical Research 44:10, pages 1216-1262.
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Peter Voss, Lubica Horakova, Manuela Jakstadt, Daniela Kiekebusch & Tilman Grune. (2006) Ferritin oxidation and proteasomal degradation: Protection by antioxidants. Free Radical Research 40:7, pages 673-683.
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Articles from other publishers (14)

Lucia Kovacikova, Magdalena Majekova & Milan Stefek. 2015. Advanced Protocols in Oxidative Stress III. Advanced Protocols in Oxidative Stress III 313 327 .
R. S. Alekseyev, A. V. Kurkin & M. A. Yurovskaya. (2011) γ-Carbolines and their hydrogenated derivatives 3.* Hydrogenated derivatives of γ-carbolines: chemical and biological poperties (Review). Chemistry of Heterocyclic Compounds 46:10, pages 1169-1198.
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Seung-Duk Ryu, Hyeon-Gyu Yi, Young-Nam Cha, Ju-Hee Kang, Ju-Seup Kang, Yong-Cheol Jeon, Hwon-Kyum Park, Tae-Moo Yu, Jung-Nam Lee & Chang-Shin Park. (2004) Flavin-containing monooxygenase activity can be inhibited by nitric oxide-mediated S-nitrosylation. Life Sciences 75:21, pages 2559-2572.
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Azara Janmohamed, Colin T Dolphin, Ian R Phillips & Elizabeth A Shephard. (2001) Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450 2 2Abbreviations: FMO, flavin-containing monooxygenase; CYP, cytochrome P450; KGM, keratinocyte growth medium; DMEM, Dulbecco’s modified Eagle’s medium.. Biochemical Pharmacology 62:6, pages 777-786.
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L. ??olt�s, ??. Bezek, E. Ujh�zy & V. Bauer. (2000) Extraction and chromatographic separation methods in pharmacokinetic studies of Stobadine�?an indole-related antioxidant and free-radical scavenger. Biomedical Chromatography 14:3, pages 188-201.
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Š. Bezek, L. Šortés, V. Ščasnár, K. Bauerová, Z. Kállay, M. Ďurišová, D. Mihalová, P. Bohov, V. Faberová, M. Kukan, T. Trnovec & V. Koprda. (1999) Pharmacokinetic study of stobadine. Life Sciences 65:18-19, pages 2003-2005.
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Chang-Shin Park, Hyun-Moon Baek, Woon-Gye Chung, Kyung-Hoon Lee, Seung-Duk Ryu & Young-Nam Cha. (1999) Suppression of Flavin-Containing Monooxygenase by Overproduced Nitric Oxide in Rat Liver. Molecular Pharmacology 56:3, pages 507-514.
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Jodan D Ratz, John J McGuire & Brian M Bennett. (2009) Enantioselective inhibition of the biotransformation and pharmacological actions of isoidide dinitrate by diphenyleneiodonium sulphate. British Journal of Pharmacology 126:1, pages 61-68.
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John J. McGuire, Diane J. Anderson, Bernard J. McDonald, Ramani Narayanasami & Brian M. Bennett. (1998) Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate. Biochemical Pharmacology 56:7, pages 881-893.
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L' Horáková & S Štolc. (1998) Antioxidant and Pharmacodynamic Effects of Pyridoindole Stobadine. General Pharmacology: The Vascular System 30:5, pages 627-638.
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M. Stefek, I. Drozdikova & K. Vajdova. (1996) The pyridoindole antioxidant stobadine inhibited glycation-induced absorbance and fluorescence changes in albumin. Acta Diabetologica 33:1, pages 35-40.
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Peter Hlavica & Michael Lehnerer. (2006) Some aspects of the role of cytochrome P‐450 isozymes in the n‐oxidative transformation of secondary and tertiary amine compounds. Journal of Biochemical Toxicology 10:5, pages 275-285.
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Lubica Horáková, Helmut Sies & Steen Steenken. 1994. Oxygen Radicals in Biological Systems Part D. Oxygen Radicals in Biological Systems Part D 572 580 .
P. Hlavica & I. Golly. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 71 90 .

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