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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 6
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Research Article

The Application of Nuclear Magnetic Resonance Spectroscopy to Drug Metabolism Studies

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Pages 583-607 | Received 22 Aug 1988, Accepted 21 Jan 1989, Published online: 22 Sep 2008

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M. E. Bollard, E. Holmes, C. A. Blackledge, J. C. Lindon, I. D. Wilson & J. K. Nicholson. (1996) 1H and 19F-nmr spectroscopic studies on the metabolism and urinary excretion of mono- and disubstituted phenols in the rat. Xenobiotica 26:3, pages 255-273.
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J. R. Sneyd, P. J. Simons & B. Wright. (1994) Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient. Xenobiotica 24:10, pages 1021-1028.
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P. J. Gilbert, T. E. Hartley, J. A. Troke, R. G. Turcan, C. W. Vose & K. V. Watson. (1992) Application of 19F.n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor. Xenobiotica 22:7, pages 775-787.
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Articles from other publishers (25)

J.C. Lindon. 2016. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Alexander V. LyubimovMichael D. Reily, Stella Huang, Janet Caceres‐Cortes, Kim Johnson & Yue‐Zhong Shu. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
S C Connor, J R Everett, K R Jennings, J K Nicholson & G Woodnutt. (1994) High Resolution 1H NMR Spectroscopic Studies of the Metabolism and Excretion of Ampicillin in Rats and Amoxycillin in Rats and Man. Journal of Pharmacy and Pharmacology 46:2, pages 128-134.
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J.C. Lindon. 2005. Encyclopedia of Analytical Science. Encyclopedia of Analytical Science 263 272 .
Alaa-Eldin F Nassar & Rasmy E Talaat. (2004) Strategies for dealing with metabolite elucidation in drug discovery and development. Drug Discovery Today 9:7, pages 317-327.
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E.M. Lenz, J.C. Lindon, J.K. Nicholson, J.M. Weeks & D. Osborn. (2003) 19F NMR spectroscopic investigation into the absorption and metabolism of 3-trifluoromethylaniline in Eisenia veneta. Ecotoxicology and Environmental Safety 54:2, pages 157-168.
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C.L. Gavaghan, J.K Nicholson, S.C. Connor, I.D. Wilson, B. Wright & E. Holmes. (2001) Directly Coupled High-Performance Liquid Chromatography and Nuclear Magnetic Resonance Spectroscopic with Chemometric Studies on Metabolic Variation in Sprague–Dawley Rats. Analytical Biochemistry 291:2, pages 245-252.
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J.-C Cherton, S Hamm, J.-C Hallé, L Menguy & M Beaufour. (2001) Potential proinsecticides of fluorinated carboxylic acids and β-ethanolamines. Journal of Fluorine Chemistry 107:2, pages 387-395.
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I Wilson, J Nicholson & J Lindon. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 523 550 .
Marelle G. Boersma, Tatiana Y. Dinarieva, Wouter J. Middelhoven, Willem J. H. van Berkel, Joel Doran, Jacques Vervoort & Ivonne M. C. M. Rietjens. (1998) 19 F Nuclear Magnetic Resonance as a Tool To Investigate Microbial Degradation of Fluorophenols to Fluorocatechols and Fluoromuconates . Applied and Environmental Microbiology 64:4, pages 1256-1263.
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ANNA MIDELFART, ANNE DYBDAHL, NORBERT MÜLLER, BEATHE SITTER, INGRID S. GRIBBESTAD & JOSTEIN KRANE. (1998) Dexamethasone and Dexamethasone Phosphate Detected by1H and19F NMR Spectroscopy in the Aqueous Humour. Experimental Eye Research 66:3, pages 327-337.
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Andrew W. Nicholls, Stephen Caddick, Ian D. Wilson, R.Duncan Farrant, John.C. Lindon & Jeremy K. Nicholson. (1995) High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat. Biochemical Pharmacology 49:8, pages 1155-1164.
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David A. Ryan, Jeremy K.M. Sanders, Gerald C. Curtis & Helen Hughes. (1995) NMR study of whole rat bile: the biliary excretion of cefoperazone and benzyl chloride by an isolated perfused rat liver. Journal of Pharmaceutical and Biomedical Analysis 13:6, pages 723-734.
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J.T. Gerig. (1994) Fluorine NMR of proteins. Progress in Nuclear Magnetic Resonance Spectroscopy 26, pages 293-370.
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G. J. Peters, J. Lankelma, R. M. Kok, P. Noordhuis, C. J. van Groeningen, C. L. van der Wilt, S. Meyer & H. M. Pinedo. (1993) Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma. Cancer Chemotherapy and Pharmacology 31:4, pages 269-276.
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N. E. Preece, J. Challands & S. C. R. Williams. (2005) 19 F NMR studies of enflurane elimination and metabolism . NMR in Biomedicine 5:2, pages 101-106.
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A.R Jacobson, L.A Sylvia, D.L Veenstra & J.T Gerig. (1992) 19F[1H] NOE determinations in surface-coil experiments. Journal of Magnetic Resonance (1969) 96:2, pages 387-392.
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Kazuki Akira & Shigeo Baba. (2006) Synthesis of [1,3,5‐ 13 C 3 ]benzoic acid and [2,4,6,7‐ 13 C 4 ]benzoic acid from 13 C‐labelled sodium pyruvates . Journal of Labelled Compounds and Radiopharmaceuticals 31:2, pages 109-117.
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Alice M. Clark & Charles D. Hufford. (2006) Use of microorganisms for the study of drug metabolism: An update. Medicinal Research Reviews 11:5, pages 473-501.
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Nicholas E. Preece, Jeremy K. Nicholson & John A. Timbrell. (1991) Identification of novel hydrazine metabolites by 15N-NMR. Biochemical Pharmacology 41:9, pages 1319-1324.
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Marie-Catherine Malet-Martino, R. Martino, M. de Forni, A. Andremont, O. Hartmann & J. P. Armand. (1991) Flucytosine conversion to fluorouracil in humans: Does a correlation with gut flora status exist? A report of two cases using fluorine-19 magnetic resonance spectroscopyKonversion von Flucytosin zu Fluorouracil beim Menschen: Bezug zur Zusammensetzung der Darmflora? Bericht über Untersuchungen an zwei Fällen mittels Fluor-19 Magnet-Resonanz-Spektroskopie. Infection 19:3, pages 178-180.
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Noel H. Turner. (2002) Surface analysis: x-ray photoelectron spectroscopy and Auger electron spectroscopy. Analytical Chemistry 62:12, pages 113-125.
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J. D. Bell, D. G. Gadian & N. E. Preece. (1990) NMR studies of drug metabolism and disposition. European Journal of Drug Metabolism and Pharmacokinetics 15:2, pages 127-133.
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T.D. Spurway, K.P.R. Gartland, A. Warrander, R. Pickford, J.K. Nicholson & I.D. Wilson. (1990) Proton nuclear magnetic resonance of urine and bile from paracetamol dosed rats. Journal of Pharmaceutical and Biomedical Analysis 8:8-12, pages 969-973.
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F.Y.K. Ghauri, C.A. Blackledge, I.D. Wilson & J.K. Nicholson. (1990) Studies on the metabolism of fluorinated xenobiotics in the rat using 19F-NMR and 1H-NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 8:8-12, pages 939-944.
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