Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
31
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Microsomal metabolism of fluoroanilines

&
Pages 1297-1305 | Received 11 Jan 1989, Accepted 12 Apr 1989, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Silvi A. Chacko, Wu Yang, Yufeng Wang, Yuan Tian, Yang Hong, Michael Wallace, Bonnie Wang, William R. Ewing, Joseph M. Luettgen, Yue-Zhong Shu & Lisa J. Christopher. (2021) Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor. Xenobiotica 51:8, pages 933-948.
Read now
M. E. Bollard, E. Holmes, C. A. Blackledge, J. C. Lindon, I. D. Wilson & J. K. Nicholson. (1996) 1H and 19F-nmr spectroscopic studies on the metabolism and urinary excretion of mono- and disubstituted phenols in the rat. Xenobiotica 26:3, pages 255-273.
Read now
K. Sakamoto, Y. Nakamura, S. Aikoh, T. Baba, J. Perregaard, H. Pedersen, E. K. Moltzen, D. J. Mulford & T. Yamaguchi. (1995) Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism. Xenobiotica 25:12, pages 1327-1343.
Read now
P. N. Rizk & R. P. Hanzlik. (1995) Oxidative and non-oxidative metabolism of 4-iodoanisole by rat liver microsomes. Xenobiotica 25:2, pages 143-150.
Read now
S. Boeren, B. Tyrakowska, J. Vervoort, E. de Hoffman, K. Teunis, A. Van Veldhuizen & I. M. C. M. Rietjens. (1992) Rat liver microsomal metabolism of 2-halogenated 4-methylanilines. Xenobiotica 22:12, pages 1403-1423.
Read now
G. J. M. Horbach, J. G. Van Asten, I. M. C. M. Rietjens, P. Kremers & C. F. A. Van Bezooijen. (1992) The effect of age on inducibility of various types of rat liver cytochrome P-450. Xenobiotica 22:5, pages 515-522.
Read now
M. J. Galmier, J. F. Pognat, C. Lartigue-Mattei, J. L. Chabard, M. Bastide, N. Busch & J. A. Berger. (1991) Biotransformation study of para-substituted phenylpiperazines in Beagle dogs by gas chromatography-mass spectrometry. Xenobiotica 21:10, pages 1371-1384.
Read now
J. Vervoort, P. A. De Jager, J. Steenbergen & I. M. C. M. Rietjens. (1990) Development of a 19F-n.m.r. method for studies on the in vivo and in vitro metabolism of 2-fluoroaniline. Xenobiotica 20:7, pages 657-670.
Read now

Articles from other publishers (27)

Sofia Moco. (2022) Studying Metabolism by NMR-Based Metabolomics. Frontiers in Molecular Biosciences 9.
Crossref
Alexander B. Sorokin. 2022. Recent Highlights II. Recent Highlights II 23 63 .
Yasushi Yamazoe & Kouichi Yoshinari. (2017) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. Drug Metabolism and Pharmacokinetics 32:5, pages 229-247.
Crossref
Maite Docampo, Adiji Olubu, Xiaoqiang Wang, Giulio Pasinetti & Richard A. Dixon. (2017) Glucuronidated Flavonoids in Neurological Protection: Structural Analysis and Approaches for Chemical and Biological Synthesis. Journal of Agricultural and Food Chemistry 65:35, pages 7607-7623.
Crossref
Kurtis M. Carsch, Graham de Ruiter & Theodor Agapie. (2017) Intramolecular C–H and C–F Bond Oxygenation by Site-Differentiated Tetranuclear Manganese Models of the OEC. Inorganic Chemistry 56:15, pages 9044-9054.
Crossref
Alexander B. Sorokin. 2017. Inorganic Reaction Mechanisms. Inorganic Reaction Mechanisms 107 165 .
Xiao-Xi Li, Yong Wang, Qing-Chuan Zheng & Hong-Xing Zhang. (2016) Detoxification of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes: A theoretical investigation. Journal of Inorganic Biochemistry 154, pages 21-28.
Crossref
Kenjiro Sato, Hiroki Takahagi, Osamu Kubo, Kousuke Hidaka, Takeshi Yoshikawa, Masahiro Kamaura, Masanori Nakakariya, Nobuyuki Amano, Ryutaro Adachi, Toshiyuki Maki, Kazumi Take, Shiro Takekawa, Tomoyuki Kitazaki & Tsuyoshi Maekawa. (2015) Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities. Bioorganic & Medicinal Chemistry 23:15, pages 4544-4560.
Crossref
Cédric Colomban, Evgenij V. Kudrik, Pavel Afanasiev & Alexander B. Sorokin. (2014) Catalytic Defluorination of Perfluorinated Aromatics under Oxidative Conditions Using N-Bridged Diiron Phthalocyanine. Journal of the American Chemical Society 136:32, pages 11321-11330.
Crossref
Xiaohai Li, Theodore M. Kamenecka & Michael D. Cameron. (2009) Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Gefitinib: Implications for Pulmonary and Hepatic Toxicities. Chemical Research in Toxicology 22:10, pages 1736-1742.
Crossref
E.M. Lenz, J.C. Lindon, J.K. Nicholson, J.M. Weeks & D. Osborn. (2003) 19F NMR spectroscopic investigation into the absorption and metabolism of 3-trifluoromethylaniline in Eisenia veneta. Ecotoxicology and Environmental Safety 54:2, pages 157-168.
Crossref
Robert H. H. van den Heuvel, Marco W. Fraaije, Colja Laane & Willem J. H. van Berkel. (2001) Enzymatic Synthesis of Vanillin. Journal of Agricultural and Food Chemistry 49:6, pages 2954-2958.
Crossref
. 2001. Metabolic Maps. Metabolic Maps 288 295 .
Bożena Tyrakowska, Nicole H.P. Cnubben, Ans E.M.F. Soffers, Th. Wobbes & Ivonne M.C.M. Rietjens. (1996) Comparative MO-QSAR studies in various species including man. Chemico-Biological Interactions 100:2, pages 187-201.
Crossref
H.E.M.G. Haenen, I.M.C.M. Rietjens, J. Vervoort, J.H.M. Temmink & P.J. van Bladeren. (1995) In vitro metabolism of 5-fluoro-2-glutathionyl-nitrobenzene by kidney proximal tubular cells studied by 19F-NMR. Chemico-Biological Interactions 98:2, pages 97-112.
Crossref
Frank S. LaBella & Gary Queen. (1995) Subanesthetic concentrations of drugs inhibit cytochrome P450-mediated metabolism of aniline. European Journal of Pharmacology: Environmental Toxicology and Pharmacology 293:3, pages 231-235.
Crossref
Janneke Koerts, Ivonne M.C.M. Rietjens, Marelle G. Boersma & Jacques Vervoort. (1995) 1 H NMR T 1 relaxation rate study on substrate orientation of fluoromethylanilines in the active sites of microsomal and purified cytochromes P 450 1A1 and 2B1 . FEBS Letters 368:2, pages 279-284.
Crossref
Nicole H.P. Cnubben, Jacques Vervoort, Marelle G. Boersma & Ivonne M.C.M. Rietjens. (1995) The effect of varying halogen substituent patterns on the cytochrome P450 catalysed dehalogenation of 4-halogenated anilines to 4-aminophenol metabolites. Biochemical Pharmacology 49:9, pages 1235-1248.
Crossref
Ivonne M.C.M. Rietjens, Nicole H.P. Cnubben, Marjon van Haandel, Bozena Tyrakowska, Ans E.M.F. Soffers & Jacques Vervoort. (1995) Different metabolic pathways of 2,5-difluoronitrobenzene and 2,5-difluoroaminobenzene compared to molecular orbital substrate characteristics. Chemico-Biological Interactions 94:1, pages 49-72.
Crossref
J.T. Gerig. (1994) Fluorine NMR of proteins. Progress in Nuclear Magnetic Resonance Spectroscopy 26, pages 293-370.
Crossref
Ivonne M. C. M. Rietjens, Ans E. M. F. Soffers, Cees Veeger & Jacques Vervoort. (2002) Regioselectivity of cytochrome P-450 catalyzed hydroxylation of fluorobenzenes predicted by calculated frontier orbital substrate characteristics. Biochemistry 32:18, pages 4801-4812.
Crossref
N.H.P. Cnubben, J. Vervoort, C. Veeger & I.M.C.M. Rietjens. (1992) Study on the regioselectivity and mechanism of the aromatic hydroxylation of monofluoroanilines. Chemico-Biological Interactions 85:2-3, pages 151-172.
Crossref
Gary O. Rankin, Kelly W. Beers, Derek W. Nicoll, Dianne K. Anestis, Hsien C. Shih, Patrick I. Brown & John L. Hubbard. (1992) Role of para-hydroxylation in phensuximide-induced urotoxicity in the Fischer 344 rat. Toxicology 74:1, pages 77-88.
Crossref
J. Vervoort, I. M. C. M. Rietjens, C. T. W. Moonen, M. Von Kienlin & D. Despres. (1991) Biotransformation of 2-fluoroaniline in rats studied byIn Vivo19F NMR. NMR in Biomedicine 4:6, pages 255-261.
Crossref
I.M.C.M. Rietjens & J. Vervoort. (1991) Bioactivation of 4-fluorinated anilines to benzoquinoneimines as primary reaction products. Chemico-Biological Interactions 77:3, pages 263-281.
Crossref
I. M. C. M. Rietjens, J. Koerts, S. Boeren & J. Vervoort. (2010) Biosynthesis and chemical determination of polyfluoro-4-hydroxyanilines. Recueil des Travaux Chimiques des Pays-Bas 110:5, pages 216-221.
Crossref
Ivonne M. C. M. RIETJENS, Bozena TYRAKOWSKA, Cees VEEGER & Jacques VERVOORT. (2005) Reaction pathways for biodehalogenation of fluorinated anilines. European Journal of Biochemistry 194:3, pages 945-954.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.