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H. Kaspar Binz, Talitha R. Bakker, Douglas J. Phillips, Andreas Cornelius, Christof Zitt, Thomas Göttler, Gabriel Sigrist, Ulrike Fiedler, Savira Ekawardhani, Ignacio Dolado, Johan Abram Saliba, Gaby Tresch, Karl Proba & Michael T. Stumpp. (2017) Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate. mAbs 9:8, pages 1262-1269.
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Seigo Sanoh, Yoichi Naritomi, Mami Fujimoto, Koya Sato, Akio Kawamura, Aya Horiguchi, Kazumi Sugihara, Yaichiro Kotake, Hiroki Ohshita, Chise Tateno, Toru Horie, Shigeyuki Kitamura & Shigeru Ohta. (2015) Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver. Xenobiotica 45:7, pages 605-614.
Read now
Read now
LorenzR. Rhomberg. (2009) Uptake Kinetics, Species Differences, and the Determination of Equivalent Combinations of Air Concentration and Exposure Duration for Assessment of Acute Inhalation Toxicity. Human and Ecological Risk Assessment: An International Journal 15:6, pages 1099-1145.
Read now
Read now
Bas G.H. Bokkers & Wout Slob. (2007) Deriving a Data-Based Interspecies Assessment Factor Using the NOAEL and the Benchmark Dose Approach. Critical Reviews in Toxicology 37:5, pages 355-373.
Read now
Read now
LorenzR. Rhomberg & ThomasA. Lewandowski. (2006) Methods for Identifying a Default Cross-Species Scaling Factor. Human and Ecological Risk Assessment: An International Journal 12:6, pages 1094-1127.
Read now
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Stephen W. Borron, Michael Stonerook & Frances Reid. (2006) Efficacy of Hydroxocobalamin for the Treatment of Acute Cyanide Poisoning in Adult Beagle Dogs. Clinical Toxicology 44:sup1, pages 5-15.
Read now
Read now
K. W Ward, R Nagilla & L. J Jolivette. (2005) Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. Xenobiotica 35:2, pages 191-210.
Read now
Read now
Chang Youn Cho, Beom Soo Shin, Ji Hoon Jung, Dong Hwan Kim, Kang Choon Lee, Soon-Young Han, Hyung Sik Kim, Byung Mu Lee & Sun Dong Yoo. (2002) Pharmacokinetic scaling of bisphenol A by species-invariant time methods. Xenobiotica 32:10, pages 925-934.
Read now
Read now
Marina Villafañe Evans & Christopher R. Eklund. (2001) A Graphical Application of Sensitivity Analysis for Gas Uptake Experiments Using Chloroform as an Example. Toxicology Methods 11:4, pages 285-297.
Read now
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A. Leusch, W. Troger, A. Greischel & W. Roth. (2000) Pharmacokinetics of the M1-agonist talsaclidine in mouse, rat, rabbit and monkey, and extrapolation to man. Xenobiotica 30:8, pages 797-814.
Read now
Read now
C. H. PIERCE. (1999) A comparison of 1H8-and 2H8-toluene toxicokinetics in men. Xenobiotica 29:1, pages 93-108.
Read now
Read now
P. SANWALD-DUCRAY & J. DOW*. (1997) Prediction of the pharmacokinetic parameters of reduced- dolasetron in man using in vitro-in vivo and interspecies allometric scaling. Xenobiotica 27:2, pages 189-201.
Read now
Read now
M. T. Angley, L. N. Sansom & I. Stupans. (1995) Cyclophosphamide administered repeatedly to the male rat and as a single dose to the female rat. Its effects on hepatic and pulmonary P450 and associated enzymes. Xenobiotica 25:10, pages 1051-1062.
Read now
Read now
H. Sano, H. Sato, S. Furuta, M. Motogi & Y. Matsuki. (1991) Pharmacokinetics of nizatidine in dogs and rats. Xenobiotica 21:10, pages 1257-1264.
Read now
Read now
Articles from other publishers (94)
G.P. Gakis, A. Krikas, P. Neofytou, L. Tran & C. Charitidis. (2022) Modelling the biodistribution of inhaled gold nanoparticles in rats with interspecies extrapolation to humans. Toxicology and Applied Pharmacology 457, pages 116322.
Crossref
Crossref
Fazel Abdolahpur Monikh, Martina G. Vijver, Raine Kortet, Iseult Lynch & Willie J. G. M. Peijnenburg. (2022) Emerging investigator series: perspectives on toxicokinetics of nanoscale plastic debris in organisms. Environmental Science: Nano 9:5, pages 1566-1577.
Crossref
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Nicolas Frances, Marina Bacac, Katharine Bray-French, François Christen, Heather Hinton, Elisabeth Husar, Elizabeth Quackenbush, Martin Schäfer, Eginhard Schick, Arthur Van De Vyver & Wolfgang F. Richter. (2022) Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab. Journal of Pharmaceutical Sciences 111:4, pages 1208-1218.
Crossref
Crossref
Mario González-Sales, Nick Holford, Guillaume Bonnefois & Julie Desrochers. (2021) Wide size dispersion and use of body composition and maturation improves the reliability of allometric exponent estimates. Journal of Pharmacokinetics and Pharmacodynamics 49:2, pages 151-165.
Crossref
Crossref
Sergey Aksenov, John C. Roberts, Ganesh Mugundu, Karen Thudium Mueller, Indranil Bhattacharya & Michael A. Tortorici. (2021) Current and Next Steps Toward Prediction of Human Dose for Gene Therapy Using Translational Dose‐Response Studies. Clinical Pharmacology & Therapeutics 110:5, pages 1176-1179.
Crossref
Crossref
Younggil Kwon. (2020) A New Pharmacokinetic Approach for a Better Understanding of the Relationship Between the Terminal Half-Life of Drug and Its Physiologically Based Pharmacokinetic Parameters. Journal of Pharmaceutical Sciences 109:3, pages 1421-1423.
Crossref
Crossref
Sarah E. Lee, Monica Duran-Martinez, Sabina Khantsis, Diana W. Bianchi & Faycal Guedj. (2020) Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome. Trends in Molecular Medicine 26:2, pages 150-169.
Crossref
Crossref
Go-Wun Choi, Yong-Bok Lee & Hea-Young Cho. (2019) Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling. Pharmaceutics 11:4, pages 168.
Crossref
Crossref
Ching‐Han Yu, Shu‐Chen Chu, Shun‐Fa Yang, Yih‐Shou Hsieh, Chih‐Yi Lee & Pei‐Ni Chen. (2018)
Induction of apoptotic but not autophagic cell death by
Cinnamomum cassia
extracts on human oral cancer cells
. Journal of Cellular Physiology 234:4, pages 5289-5303.
Crossref
Crossref
Haruka Nishimuta, Takao Watanabe & Kiyoko Bando. (2019) Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes. The AAPS Journal 21:2.
Crossref
Crossref
Tae Hwan Kim, Soyoung Shin & Beom Soo Shin. (2017) Model-based drug development: application of modeling and simulation in drug development. Journal of Pharmaceutical Investigation 48:4, pages 431-441.
Crossref
Crossref
Daniel Steiner, Frieder W Merz, Ivo Sonderegger, Maya Gulotti-Georgieva, Denis Villemagne, Douglas J Phillips, Patrik Forrer, Michael T Stumpp, Christof Zitt & H Kaspar Binz. (2017) Half-life extension using serum albumin-binding DARPin® domains. Protein Engineering, Design and Selection 30:9, pages 583-591.
Crossref
Crossref
Elizabeth C.M. de Lange. 2015. Blood‐Brain Barrier in Drug Discovery. Blood‐Brain Barrier in Drug Discovery
296
323
.
S. M. D. K. Ganga Senarathna & Kevin T. Batty. (2014) Interspecies Allometric Scaling of Antimalarial Drugs and Potential Application to Pediatric Dosing. Antimicrobial Agents and Chemotherapy 58:10, pages 6068-6078.
Crossref
Crossref
Shu-Chen Chu, Yih-Shou Hsieh, Cheng-Chia Yu, Yi-Yeh Lai & Pei-Ni Chen. (2014) Thymoquinone Induces Cell Death in Human Squamous Carcinoma Cells via Caspase Activation-Dependent Apoptosis and LC3-II Activation-Dependent Autophagy. PLoS ONE 9:7, pages e101579.
Crossref
Crossref
Elizabeth C. M. de Lange. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain
233
268
.
Elizabeth CM de Lange. (2013) The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects. Fluids and Barriers of the CNS 10:1.
Crossref
Crossref
Aidilla Mubarak, Jonathan M. Hodgson, Michael J. Considine, Kevin D. Croft & Vance B. Matthews. (2013) Supplementation of a High-Fat Diet with Chlorogenic Acid Is Associated with Insulin Resistance and Hepatic Lipid Accumulation in Mice. Journal of Agricultural and Food Chemistry 61:18, pages 4371-4378.
Crossref
Crossref
Adams Amantana, Yali Chen, Shanthakumar R. Tyavanagimatt, Kevin F. Jones, Robert Jordan, Jarasvech Chinsangaram, Tove′ C. Bolken, Janet M. Leeds & Dennis E. Hruby. (2013) Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection. PLoS ONE 8:4, pages e61514.
Crossref
Crossref
Bruce Campbell & Bob Ings. 2013. Global Approach in Safety Testing. Global Approach in Safety Testing
119
158
.
Satoru Takahashi, Hiroji Uemura, Azman Seeni, Mingxi Tang, Masami Komiya, Ne Long, Hitoshi Ishiguro, Yoshinobu Kubota & Tomoyuki Shirai. (2012) Therapeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer. The Prostate 72:14, pages 1559-1572.
Crossref
Crossref
Oscar A. Linares, Darko Stefanovski & Raymond C. Boston. (2012) Exponential Sum Modeling of Reswick and Rogers Pressure-Duration Curve: A New Analysis and Model. Journal of Basic & Applied Sciences 8:2, pages 683-689.
Crossref
Crossref
Olaf Weber, Stefan Willmann, Hilmar Bischoff, Volkhart Li, Alexandros Vakalopoulos, Klemens Lustig, Frank-Thorsten Hafner, Roland Heinig, Carsten Schmeck & Klaus Buehner. (2012) Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling. British Journal of Clinical Pharmacology 73:2, pages 219-231.
Crossref
Crossref
Mingguang Li & Joshua Reineke. 2012. Nanotoxicity. Nanotoxicity
369
382
.
Joost Westerhout, Meindert Danhof & Elizabeth C.M. De Lange. (2011) Preclinical Prediction of Human Brain Target Site Concentrations: Considerations in Extrapolating to the Clinical Setting. Journal of Pharmaceutical Sciences 100:9, pages 3577-3593.
Crossref
Crossref
Elena Puerta & Norberto Aguirre. (2011) Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): Neurodegeneration versus Neuromodulation. Pharmaceuticals 4:7, pages 992-1018.
Crossref
Crossref
Kevin T Batty, Kenneth F Ilett, M E Davis & Timothy. (1996) Chemical Stability of Artesunate Injection and Proposal for its Administration by Intravenous Infusion. Journal of Pharmacy and Pharmacology 48:1, pages 22-26.
Crossref
Crossref
Paul S. Agutter & Jack A. Tuszynski. (2011) Analytic theories of allometric scaling. Journal of Experimental Biology 214:7, pages 1055-1062.
Crossref
Crossref
Shinji Yamazaki, Judith Skaptason, David Romero, Sylvia Vekich, Hannah M. Jones, Weiwei Tan, Keith D. Wilner & Tatiana Koudriakova. (2011) Prediction of Oral Pharmacokinetics of cMet Kinase Inhibitors in Humans: Physiologically Based Pharmacokinetic Model Versus Traditional One-Compartment Model. Drug Metabolism and Disposition 39:3, pages 383-393.
Crossref
Crossref
Stephen H. Curry, Helen H. Decory & Johan Gabrielsson. 2010. Principles and Practice of Pharmaceutical Medicine. Principles and Practice of Pharmaceutical Medicine
84
106
.
Marshall HamptonBethany T. Nelson & Matthew T. Andrews. (2010) Circulation and metabolic rates in a natural hibernator: an integrative physiological model. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 299:6, pages R1478-R1488.
Crossref
Crossref
Mingguang Li, Khuloud T. Al-Jamal, Kostas Kostarelos & Joshua Reineke. (2010) Physiologically Based Pharmacokinetic Modeling of Nanoparticles. ACS Nano 4:11, pages 6303-6317.
Crossref
Crossref
Stephen H. Curry & Robin Whelpton. 2010. Drug Disposition and Pharmacokinetics. Drug Disposition and Pharmacokinetics
269
278
.
Lorrene A. Buckley, Parag Garhyan, Rafael Ponce & Stanley A. Roberts. 2010. Early Drug Development. Early Drug Development
421
463
.
Wai Mun LokeJulie M. ProudfootJonathan M. HodgsonAllan J. McKinleyNeil HimeMaria MagatRoland StockerKevin D. Croft. (2010) Specific Dietary Polyphenols Attenuate Atherosclerosis in Apolipoprotein E–Knockout Mice by Alleviating Inflammation and Endothelial Dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology 30:4, pages 749-757.
Crossref
Crossref
Kevin T. Batty, Brioni R. Moore, Verity Stirling, Kenneth F. Ilett, Madhu Page-Sharp, Keith B. Shilkin, Ivo Mueller, Stephen J. Rogerson, Harin A. Karunajeewa & Timothy M.E. Davis. (2010) Investigation of reproductive toxicity of piperaquine in mice. Reproductive Toxicology 29:2, pages 206-213.
Crossref
Crossref
Kannan Krishnan, George D. Loizou, Martin Spendiff, John C. Lipscomb & Melvin E. Andersen. 2010. Quantitative Modeling in Toxicology. Quantitative Modeling in Toxicology
19
58
.
William L. Hayton & Teh‐Min Hu. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
28
.
Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
Crossref
Crossref
Masayuki Takahashi, Takuo Washio, Norio Suzuki, Katsuhiro Igeta & Shinji Yamashita. (2009) The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans. Journal of Pharmaceutical Sciences 98:11, pages 4343-4353.
Crossref
Crossref
Hye Young Ji, Beom Soo Shin, Dong Won Jeong, Eun Jeong Park, Eun-Seok Park, Sun Dong Yoo & Hye Suk Lee. (2009) Interspecies scaling of oleanolic acid in mice, rats, rabbits and dogs and prediction of human pharmacokinetics. Archives of Pharmacal Research 32:2, pages 251-257.
Crossref
Crossref
Aberra Fura, Viral Vyas, William Humphreys, Anjaneya Chimalokonda & David Rodrigues. (2008) Prediction of human oral pharmacokinetics using nonclinical data: examples involving four proprietary compounds. Biopharmaceutics & Drug Disposition 29:8, pages 455-468.
Crossref
Crossref
Byung-Kwon Park, Jong-Hwan Lim, Myoung-Seok Kim, Youn-Hwan Hwang & Hyo-In Yun. (2008) Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in dogs. Research in Veterinary Science 84:1, pages 85-89.
Crossref
Crossref
Massimiliano Germani, Patrizia Crivori, Maurizio Rocchetti, Philip S. Burton, Alan G.E. Wilson, Mark E. Smith & Italo Poggesi. (2007) Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study. European Journal of Pharmaceutical Sciences 31:3-4, pages 190-201.
Crossref
Crossref
Venkata V. Pavankuamr, C. A. Vinu, Ramesh Mullangi & Nuggehally R. Srinivas. (2007) Preclinical pharmacokinetics and interspecies scaling of ragaglitazar, a novel biliary excreted PPAR dual activator. European Journal of Drug Metabolism and Pharmacokinetics 32:1, pages 29-37.
Crossref
Crossref
ROBERT L. DEDRICK & ARTHUR J. ATKINSONJr.Jr.. 2007. Principles of Clinical Pharmacology. Principles of Clinical Pharmacology
463
471
.
J.V. Turner & S. Agatonovic-Kustrin. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
699
724
.
Lang Tran & Eileen Kuempel. 2006. Particle Toxicology. Particle Toxicology
351
386
.
Sean K Kelley, Thomas Gelzleichter, Dong Xie, Wyne P Lee, Walter C Darbonne, Ferhan Qureshi, Kim Kissler, Ezogelin Oflazoglu & Iqbal S Grewal. (2006) Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates. British Journal of Pharmacology 148:8, pages 1116-1123.
Crossref
Crossref
J English. 2006. Toxicological Testing Handbook. Toxicological Testing Handbook
79
107
.
Christopher A. Evans, Larry J. Jolivette, Rakesh Nagilla & Keith W. Ward. (2006) EXTRAPOLATION OF PRECLINICAL PHARMACOKINETICS AND MOLECULAR FEATURE ANALYSIS OF “DISCOVERY-LIKE” MOLECULES TO PREDICT HUMAN PHARMACOKINETICS. Drug Metabolism and Disposition 34:7, pages 1255-1265.
Crossref
Crossref
Annis Mechan, Jie Yuan, George Hatzidimitriou, Rodney J Irvine, Una D McCann & George A Ricaurte. (2005) Pharmacokinetic Profile of Single and Repeated Oral Doses of MDMA in Squirrel Monkeys: Relationship to Lasting Effects on Brain Serotonin Neurons. Neuropsychopharmacology 31:2, pages 339-350.
Crossref
Crossref
Catherijne A. J. Knibbe, Klaas P. Zuideveld, Leon P. H. J. Aarts, Paul F. M. Kuks & Meindert Danhof. (2005) Allometric relationships between the pharmacokinetics of propofol in rats, children and adults. British Journal of Clinical Pharmacology 59:6, pages 705-711.
Crossref
Crossref
Selwyn J Hurwitz, Michael J Otto & Raymond F Schinazi. (2016) Comparative Pharmacokinetics of Racivir®, (±)-β-2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine in Rats, Rabbits, Dogs, Monkeys and HIV-Infected Humans. Antiviral Chemistry and Chemotherapy 16:2, pages 117-127.
Crossref
Crossref
Keith W. Ward, Paul Erhardt & Kenneth Bachmann. (2005) Application of simple mathematical expressions to relate the half-lives of xenobiotics in rats to values in humans. Journal of Pharmacological and Toxicological Methods 51:1, pages 57-64.
Crossref
Crossref
D. K. Walker. (2004) The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development. British Journal of Clinical Pharmacology 58:6, pages 601-608.
Crossref
Crossref
Michael Pelekis & Kannan Krishnan. (2004) Magnitude and mechanistic determinants of the interspecies toxicokinetic uncertainty factor for organic chemicals. Regulatory Toxicology and Pharmacology 40:3, pages 264-271.
Crossref
Crossref
E.-I. Lepist & W. J. Jusko. (2004) Modeling and allometric scaling of s(+)-ketoprofen pharmacokinetics and pharmacodynamics: a retrospective analysis. Journal of Veterinary Pharmacology and Therapeutics 27:4, pages 211-218.
Crossref
Crossref
Keith W. Ward & Brian R. Smith. (2004) A COMPREHENSIVE QUANTITATIVE AND QUALITATIVE EVALUATION OF EXTRAPOLATION OF INTRAVENOUS PHARMACOKINETIC PARAMETERS FROM RAT, DOG, AND MONKEY TO HUMANS. II. VOLUME OF DISTRIBUTION AND MEAN RESIDENCE TIME. Drug Metabolism and Disposition 32:6, pages 612-619.
Crossref
Crossref
Keith W. Ward & Brian R. Smith. (2004) A COMPREHENSIVE QUANTITATIVE AND QUALITATIVE EVALUATION OF EXTRAPOLATION OF INTRAVENOUS PHARMACOKINETIC PARAMETERS FROM RAT, DOG, AND MONKEY TO HUMANS. I. CLEARANCE. Drug Metabolism and Disposition 32:6, pages 603-611.
Crossref
Crossref
Shinji Yamazaki, Lisa N. Toth, Meredith L. Black & J. Neil Duncan. (2004)
COMPARISON OF PREDICTION METHODS FOR IN VIVO CLEARANCE OF (
S
,
S
)-3-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE HYDROCHLORIDE, A DOPAMINE D2 RECEPTOR ANTAGONIST, IN HUMANS
. Drug Metabolism and Disposition 32:4, pages 398-404.
Crossref
Crossref
Thierry Lavé, Olivier Luttringer, Patrick Poulin & Neil Parrott. 2004. Applications of Pharmacokinetic Principles in Drug Development. Applications of Pharmacokinetic Principles in Drug Development
133
175
.
C.R Kirman, L.M Sweeney, M.E Meek & M.L Gargas. (2003) Assessing the dose-dependency of allometric scaling performance using physiologically based pharmacokinetic modeling. Regulatory Toxicology and Pharmacology 38:3, pages 345-367.
Crossref
Crossref
Beom S. Shin, Dong H. Kim, Chang Y. Cho, Si K. Park, Sun G. Chung, Eui H. Cho, Sun H. Lee, Jeong H. Joo, Ho S. Kwon, Kang C. Lee & Sun D. Yoo. (2003) Pharmacokinetic scaling of SJ‐8029, a novel anticancer agent possessing microtubule and topoisomerase inhibiting activities, by species‐invariant time methods. Biopharmaceutics & Drug Disposition 24:5, pages 191-197.
Crossref
Crossref
STEPHEN H. CURRY. (2003) Why Have So Many Drugs with Stellar Results in Laboratory Stroke Models Failed in Clinical Trials?. Annals of the New York Academy of Sciences 993:1, pages 69-74.
Crossref
Crossref
D Moneta, C Geroni, O Valota, P Grossi, M.J.A de Jonge, M Brughera, E Colajori, M Ghielmini & C Sessa. (2003) Predicting the maximum-tolerated dose of PNU-159548 (4-demethoxy-3′-deamino-3′-aziridinyl-4′-methylsulphonyl-daunorubicin) in humans using CFU-GM clonogenic assays and prospective validation. European Journal of Cancer 39:5, pages 675-683.
Crossref
Crossref
Ivan Nestorov. (2003) Whole Body Pharmacokinetic Models. Clinical Pharmacokinetics 42:10, pages 883-908.
Crossref
Crossref
E Dybing, J Doe, J Groten, J Kleiner, J O'Brien, A.G Renwick, J Schlatter, P Steinberg, A Tritscher, R Walker & M Younes. (2002) Hazard characterisation of chemicals in food and diet. Food and Chemical Toxicology 40:2-3, pages 237-282.
Crossref
Crossref
Stephen V. Frye, H. Neal Bramson, David J. Hermann, Frank W. Lee, Achintya K. Sinhababu & Gaochao Tian. 2002. Integration of Pharmaceutical Discovery and Development. Integration of Pharmaceutical Discovery and Development
393
422
.
. 2002. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
207
228
.
Joseph A Grillo, Jürgen Venitz & Joseph P Ornato. (2001) Prediction of lidocaine tissue concentrations following different dose regimes during cardiac arrest using a physiologically based pharmacokinetic model. Resuscitation 50:3, pages 331-340.
Crossref
Crossref
G. Castells, B. P. S. Capece, F. Pérez, G. Martí, M. Arboix & C. Cristòfol. (2001) Allometric analysis of thiamphenicol disposition among seven mammalian species. Journal of Veterinary Pharmacology and Therapeutics 24:3, pages 193-197.
Crossref
Crossref
Julian I. Delic, Patrick D. Lilly, Alex J. MacDonald & George D. Loizou. (2000) The Utility of PBPK in the Safety Assessment of Chloroform and Carbon Tetrachloride. Regulatory Toxicology and Pharmacology 32:2, pages 144-155.
Crossref
Crossref
FREDERIC YVES BOIS. (1999) Analysis of PBPK Models for Risk Characterization. Annals of the New York Academy of Sciences 895:1 UNCERTAINTY I, pages 317-337.
Crossref
Crossref
Yuan Hua Wen, Jacob Kalff & Robert Henry Peters. (1999) Pharmacokinetic modeling in toxicology: a critical perspective. Environmental Reviews 7:1, pages 1-18.
Crossref
Crossref
L. Iavarone, J. F. Hoke, M. Bottacini, R. Barnaby & G. C. Preston. (2013) First Time in Human for GV196771: Interspecies Scaling Applied on Dose Selection. The Journal of Clinical Pharmacology 39:6, pages 560-566.
Crossref
Crossref
Burckhard Fichtl. 1999. Toxicology. Toxicology
43
82
.
Modric, Webb & Derendorf. (2002) Pharmacokinetics and pharmacodynamics of tilmicosin in sheep and cattle. Journal of Veterinary Pharmacology and Therapeutics 21:6, pages 444-452.
Crossref
Crossref
Bjarte Mortensen & Odd G. Nilsen. (2009)
Allometric Species Comparison of Toluene and
n
–Hexane Metabolism: Prediction of Hepatic Clearance in Man from Experiments with Rodent Liver S9 in a Head Space Vial Equilibration System
. Pharmacology & Toxicology 82:4, pages 183-188.
Crossref
Crossref
Crispin H. Pierce, Russell L. Dills, Thomas A. Lewandowski, Michael S. Morgan, Mike A. Wessels, Danny D. Shen & David A. Kalman. (2006) Estimation of Background Exposure to Toluene Using a Physiologically‐Based Kinetic Model. Journal of Occupational Health 39:2, pages 130-137.
Crossref
Crossref
Karen H. Watanabe & Frédéric Y. Bois. (2006) Interspecies Extrapolation of Physiological Pharmacokinetic Parameter Distributions. Risk Analysis 16:6, pages 741-754.
Crossref
Crossref
James W. Paxton. (2007) Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: THE ALLOMETRIC APPROACH FOR INTERSPECIES SCALING OF PHARMACOKINETICS AND TOXICITY OF ANTI‐CANCER DRUGS. Clinical and Experimental Pharmacology and Physiology 22:11, pages 851-854.
Crossref
Crossref
Lorenz Rhomberg. (1995) Use of quantitative modelling in methylene chloride risk assessment. Toxicology 102:1-2, pages 95-114.
Crossref
Crossref
S. Paulson, Y. Readus, S. Bulik, G. Schoenhard, J. Stolzenbach & D. Fretland. (1995) The pharmacokinetics and metabolism of SC-53228, a specific leukotriene B4 receptor antagonist. Inflammation Research 44:S2, pages S143-S144.
Crossref
Crossref
Manya T. McClure & Ieva Stupans. (1995) Hormonal perturbation as a possible mechanism for the alteration of cytochrome P450 by cyclophosphamide. Biochemical Pharmacology 49:12, pages 1827-1836.
Crossref
Crossref
Steven B. Charnick, Ryosei Kawai, Jerry R. Nedelman, Michel Lemaire, Werner Niederberger & Hitoshi Sato. (1995) Physiologically based pharmacokinetic modeling as a tool for drug development. Journal of Pharmacokinetics and Biopharmaceutics 23:2, pages 217-229.
Crossref
Crossref
Elizabeth K. Hussey, Karl H. Donn, Mick J. Daniel, Susan T. Hall, Andy J. Harker & Gary L. Evans. (2013) Interspecies Scaling and Pharmacokinetic Parameters of 3TC in Humans. The Journal of Clinical Pharmacology 34:10, pages 975-977.
Crossref
Crossref
Hans Hummler, Andrew G. Hendrickx & Heinz Nau. (2005) Maternal toxicokinetics, metabolism, and embryo exposure following a teratogenic dosing regimen with 13‐cis‐retinoic acid (isotretinoin) in the cynomolgus monkey. Teratology 50:3, pages 184-193.
Crossref
Crossref
Nishit B. Modi. (1994) Pharmacokinetics and pharmacodynamics of recombinant proteins and peptides. Journal of Controlled Release 29:3, pages 269-281.
Crossref
Crossref
Robert M. J. Ings. 1994. Use of Mechanistic Information in Risk Assessment. Use of Mechanistic Information in Risk Assessment
233
241
.
Heinz Nau. 1993. Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants. Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants
121
136
.
W.A. Ritschel, N.N. Vachharajani, R.D. Johnson & A.S. Hussain. (1992) The allometric approach for interspecies scaling of pharmacokinetic parameters. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 103:2, pages 249-253.
Crossref
Crossref
L. Lear, R.L. Nation & I. Stupans. (1992) Effects of cyclophosphamide and adriamycin on rat hepatic microsomal glucuronidation and lipid peroxidation. Biochemical Pharmacology 44:4, pages 747-753.
Crossref
Crossref
Kannan Krishnan & Melvin E. Andersen. 1992. New Trends in Pharmacokinetics. New Trends in Pharmacokinetics
203
226
.