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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 3
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Research Article

Liver slices in dynamic organ culture. II. An in vitro cellular technique for the study of integrated drug metabolism using human tissue

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Pages 341-350 | Received 09 Mar 1990, Accepted 09 Nov 1990, Published online: 22 Sep 2008

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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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Alan Boobis, Jean-Baptiste Watelet, Rhys Whomsley, Margherita Strolin Benedetti, Pascal Demoly & Keith Tipton. (2009) Drug interactions. Drug Metabolism Reviews 41:3, pages 486-527.
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C. Granhall, E. Floby, A. Nordmark, A. Orzechowski, A. Thörne, G. Tybring & A.-K. Sohlenius-Sternbeck. (2002) Characterization of testosterone metabolism and 7-hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months. Xenobiotica 32:11, pages 985-996.
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A. Steensma, J. A. Beamand, D. G. Walters, R. J. Price & B. G. Lake. (1994) Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, Cynomolgus monkey and human precision-cut liver slices. Xenobiotica 24:9, pages 893-907.
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A. Bader, K. Zech, O. Crome, U. Christians, B. Ringe, R. Pichlmayr & K-Fr. Sewing. (1994) Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica 24:7, pages 623-633.
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K. L. Salyers, J. Bark & I. G. Sipes. (1994) In vitro metabolism of theophylline by rat and human liver tissue. Xenobiotica 24:5, pages 389-399.
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I.A.M de Graaf & H.J Koster. (2003) Cryopreservation of precision-cut tissue slices for application in drug metabolism research. Toxicology in Vitro 17:1, pages 1-17.
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Keiichiro Yoneyama. (2006) Three‐dimensional visualization and physiologic evaluation of bile canaliculi in the rat liver slice by confocal laser scanning microscopy. Scanning 23:6, pages 359-365.
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A. Philip Leber Ph.D & James S. Bus. 2003. Patty's Toxicology. Patty's Toxicology.
R. Glöckner, M. Rost, K. Pissowotzki & D. Müller. (2001) Monooxygenation, conjugation and other functions in cryopreserved rat liver slices until 24 h after thawing. Toxicology 161:1-2, pages 103-109.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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Akiyo Shigematsu, Naomi Motoji, Yuko Momose, Aiko Iida & Noriko Higashi. (2000) Viability of Liver Slices Exhibiting Absorption, Metabolism, and Elimination of Substrates in Culture Medium. Experimental and Molecular Pathology 69:2, pages 119-143.
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Sean Ekins, Barbara J. Ring, James Grace, Donna J. McRobie-Belle & Steven A. Wrighton. (2000) Present and future in vitro approaches for drug metabolism. Journal of Pharmacological and Toxicological Methods 44:1, pages 313-324.
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Sanjeev Thohan & Ho Chung. 1999. Toxicity Assessment Alternatives. Toxicity Assessment Alternatives 35 52 .
J.P Cravedi, E Perdu-Durand & A Paris. (1998) Cytochrome P450-dependent metabolic pathways and glucuronidation in trout liver slices. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 121:1-3, pages 267-275.
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K.M.L. Crommentuyn, J.H.M. Schellens, J.D. van den Berg & J.H. Beijnen. (1998) In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide. Cancer Treatment Reviews 24:5, pages 345-366.
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R. Glöckner, P. Steinmetzer, C. Drobner & D. Müller. (1998) Application of cryopreserved precision-cut liver slices in pharmacotoxicology — principles, literature data and own investigations with special reference to CYP1A1-mRNA induction. Experimental and Toxicologic Pathology 50:4-6, pages 440-449.
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James L. Ferrero & Klaus Brendel. 1997. 131 169 .
Peter H. Bach, Alison E.M. Vickers, Robyn Fisher, Andreas Baumann, Eva Brittebo, David J. Carlile, Henk J. Koster, Brian G. Lake, Florence Salmon, Thomas W. Sawyer & Greg Skibinski. (2020) The Use of Tissue Slices for Pharmacotoxicology Studies. Alternatives to Laboratory Animals 24:6, pages 893-919.
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Alan R. Parrish, A.Jay Gandolfi & Klaus Brendel. (1995) Precision-cut tissue slices: Applications in pharmacology and toxicology. Life Sciences 57:21, pages 1887-1901.
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Robyn L Fisher, Steven J Hasal, I Glenn Sipes, A Jay Gandolfi & Klaus Brendel. (2016) Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slices. Human & Experimental Toxicology 14:5, pages 414-421.
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M.Suzanne Connors, Michael A. Malfatti & James S. Felton. (1995) The metabolism and DNA binding of the cooked-food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in precision-cut rat liver slices. Chemico-Biological Interactions 96:2, pages 185-202.
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R.J. Price, A.B. Renwick, J.A. Beamand, F. Esclangon, P.T. Wield, D.G. Walters & B.G. Lake. (1995) Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. Food and Chemical Toxicology 33:3, pages 233-237.
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Gregory L. Weber & I.Glenn Sipes. (1992) In vitro metabolism and bioactivation of 1,2,3-trichloropropane. Toxicology and Applied Pharmacology 113:1, pages 152-158.
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