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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 10
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Research Article

Species differences in blood profiles, metabolism and excretion of 14C-propofol after intravenous dosing to rat, dog and rabbit

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Pages 1243-1256 | Received 02 Oct 1990, Accepted 08 Feb 1991, Published online: 22 Sep 2008

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N. Murayama, M. Minoshima, M. Shimizu, F. P. Guengerich & H. Yamazaki. (2007) Involvement of human cytochrome P450 2B6 in the - and 4-hydroxylation of the anesthetic agent propofol. Xenobiotica 37:7, pages 717-724.
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B. L. Hay Kraus, D. J. Greenblatt, K. Venkatakrishnan & M. H. Court. (2000) Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences. Xenobiotica 30:6, pages 575-588.
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J. Guitton, T. Burronfosse, M. Sanchez & M. Désage. (1997) Quantitation of Propofol Metabolite, 2,6-Diisopropyl-1,4-quinol, by Gas Chromatography-Mass Spectrometry. Analytical Letters 30:7, pages 1369-1378.
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J. R. Sneyd, P. J. Simons & B. Wright. (1994) Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient. Xenobiotica 24:10, pages 1021-1028.
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P. J. Simons, I. D. Cockshott, J. B. Glen, E. A. Gordon, S. Knott & R. J. Ruane. (1992) Disposition and pharmacology of propofol glucuronide administered intravenously to animals. Xenobiotica 22:11, pages 1267-1273.
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I. D. Cockshott, E. J. Douglas, G. F. Plummer & P. J. Simons. (1992) The pharmacokinetics of propofol in laboratory animals. Xenobiotica 22:3, pages 369-375.
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P. J. Simons, I. D. Cockshott, E. J. Douglas, E. A. Gordon, S. Knott & R. J. Ruane. (1991) Distribution in female rats of an anaesthetic intravenous dose of 14C-propofol. Xenobiotica 21:10, pages 1325-1335.
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Y. L. J. M. DERYCK, K. FONCK, L. DE BAERDEMAEKER, R. NAEIJE & S. BRIMIOULLE. (2010) Differential effects of sevoflurane and propofol anesthesia on left ventricular–arterial coupling in dogs. Acta Anaesthesiologica Scandinavica 54:8, pages 979-986.
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Tao Zhu, Qiying Pang, Stuart A. McCluskey & Chaozhi Luo. (2008) Effect of propofol on hepatic blood flow and oxygen balance in rabbitsL’effet du propofol sur le débit sanguin et l’équilibre d’oxygène hépatiques chez le lapin. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 55:6, pages 364-370.
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Hiroshi Yamazaki, Makiko Shimizu, Takashi Nagashima, Masaki Minoshima & Norie Murayama. (2006) Rat Cytochrome P450 2C11 in Liver Microsomes Involved in Oxidation of Anesthetic Agent Propofol and Deactivated by Prior Treatment with Propofol. Drug Metabolism and Disposition 34:11, pages 1803-1805.
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Keith R. Branson. 2006. Manual of Equine Field Surgery. Manual of Equine Field Surgery 30 43 .
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O. Ortolani, A. Conti, Z. W. Ngumi, L. Texeira, P. Olang, I. Amani & V. C. Medrado. (2004) Ethnic differences in propofol and fentanyl response: a comparison among Caucasians, Kenyan Africans and Brazilians. European Journal of Anaesthesiology 21:4, pages 314-319.
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Anthony W O’Regan & Martin Joyce-Brady. (2003) “Pond poop” from propofol. Intensive Care Medicine 29:11, pages 2106-2106.
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Makiko Shimizu, Yoshiaki Matsumoto, Masahiro Tatsuno & Masamichi Fukuoka. (2003) Glucuronidation of Propofol and Its Analogs by Human and Rat Liver Microsomes.. Biological and Pharmaceutical Bulletin 26:2, pages 216-219.
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Peter De Paepe, Frans M. Belpaire, Gert Van Hoey, Paul A. Boon & Walter A. Buylaert. (2003) The Influence of Endotoxemia on the Pharmacokinetics and the Electroencephalographic Effect of Propofol in the Rat. Journal of Pharmaceutical Sciences 92:1, pages 104-114.
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P. Favetta, C.-S. Degoute, J.-P. Perdrix, C. Dufresne, R. Boulieu & J. Guitton. (2002) Propofol metabolites in man following propofol induction and maintenance. British Journal of Anaesthesia 88:5, pages 653-658.
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Takahiro Murai, Fujiko Tsuruta, Toshio Terao, Toshihiko Ikeda & Haruo Iwabuchi. (2002) Formation of a Structurally Novel, Serial Diglucuronide of 4-Hydroxybiphenyl by Further Glucuronidation of a Monoglucuronide in Dog Liver Microsomes. Drug Metabolism and Pharmacokinetics 17:5, pages 457-466.
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S. Tomioka & N. Nakajo. (2000) No genotoxic effect of propofol in Chinese hamster ovary cells: Analysis by sister chromatid exchanges. Acta Anaesthesiologica Scandinavica 44:10, pages 1261-1265.
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Ta-Liang Chen, Tyng-Guey Chen, Yu-Ting Tai, Huai-Chia Chang, Ruei-Ming Chen, Chen-Jung Lin & Tzuu-Huei Ueng. (2000) Propofol inhibits renal cytochrone P450 activity and enflurance defluorinationin vitro in hamsters. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 47:7, pages 680-686.
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T.B. Vree, A.J. Lagerwerf, C.P. Bleeker & P.M.R.M. de Grood. (1999) Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man. Journal of Chromatography B: Biomedical Sciences and Applications 721:2, pages 217-228.
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Gerard J. Mulder. (1998) 5 Glucuronidation and anaesthesia. Baillière's Clinical Anaesthesiology 12:2, pages 229-245.
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