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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 5
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Research Article

Simplified approach for evaluation of hepatic drug-oxidizing capacity with a simultaneous measurement of caffeine and its primary demethylated metabolites in carbon tetrachloride-intoxicated rats

E. Tanaka Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan
,
A. Ishikawa Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan
,
Y. Yamamoto Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan
,
E. Uchida Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan
,
S. Kobayashi Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan
,
H. Yasuhara Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan
&
S. Misawa Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken, Japan
 show all
Pages 535-541 | Received 13 Aug 1991, Accepted 20 Dec 1991, Published online: 22 Sep 2008

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Kamil Uney, Ilyas Tumer & Bünyamin Traş. (2011) Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats. Xenobiotica 41:7, pages 585-592.
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E. Tanaka, A. Ishikawa & S. Misawa. (1995) Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat. Xenobiotica 25:10, pages 1111-1118.
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G. O. Kokwaro, I. S. F. Szwandt, A. P. Glazier, S. A. Ward & G. Edwards. (1993) Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever. Xenobiotica 23:12, pages 1391-1397.
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Articles from other publishers (7)

Kamil UNEY & Bünyamin TRAS. (2011) Comparative Pharmacokinetics and Metabolisms of Caffeine in Sheep Breeds. Journal of Veterinary Medical Science 73:1, pages 25-31.
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Bertil B. FredholmMaurice J. Arnaud. 2011. Methylxanthines. Methylxanthines 33 91 .
E Tanaka. (2016) Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride intoxicated rat. Human & Experimental Toxicology 20:8, pages 381-385.
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Sanae Fujiko, Hayashi Hisao, Chisaki Keigo & Komatsu Yasuhiro. (1999) Effects of Saiko-ka-ryukotsu-borei-to, a Japanese Kampo Medicine, on Tachycardia and Central Nervous System Stimulation Induced by Theophylline in Rats and Mice. Japanese Journal of Pharmacology 79:3, pages 283-288.
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Jadwiga Jodynis-Liebert & Arleta Matuszewska. (1999) Effect of toluidines and dinitrotoluenes on caffeine metabolic ratio in rat. Toxicology Letters 104:1-2, pages 159-165.
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Andrew Francis & Laura Fochtmann. (1994) Caffeine augmentation of electroconvulsive seizures. Psychopharmacology 115:3, pages 320-324.
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DM Warburton. (2012) Proceedings of the British Pharmacological Society. Clinical Pharmacology Section. 14‐16 April 1993. Abstracts.. British Journal of Clinical Pharmacology 36:2.
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