Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 5
Submit an article Journal homepage
11
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Simplified approach for evaluation of hepatic drug-oxidizing capacity with a simultaneous measurement of caffeine and its primary demethylated metabolites in carbon tetrachloride-intoxicated rats

E. Tanaka Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan
,
A. Ishikawa Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan
,
Y. Yamamoto Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan
,
E. Uchida Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan
,
S. Kobayashi Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan
,
H. Yasuhara Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan
&
S. Misawa Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken, Japan
 show all
Pages 535-541 | Received 13 Aug 1991, Accepted 20 Dec 1991, Published online: 22 Sep 2008

References

  • Aldridge A., Parsons W. D., Neims A. H. Simulation of caffeine metabolism in the rat by 3-methylcholanthrene. Life Sciences 1977; 21: 967–974
  • Barstow L., Small R. E. Liver function assessment by drug metabolism. Pharmacotherapy 1990; 10: 280–288
  • Bonati M., Latini R., Marzi E., Cantoni R., Belvedere G. [2-14C] caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes by high pressure liquid chromatography. Toxicology Letters 1980; 7: 1–7
  • Branch R. A. Drugs as indicators of hepatic function. Hepatology 1982; 2: 97–105
  • Campbell M. E., Grant D. M., Inaba M., Kalow W. Biotransformation of caffeine, paraxanthine, theophylline and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P450 in human liver microsomes. Drug Metabolism and Disposition 1987; 15: 237–249
  • Cheng W. S. C., Murphy T. L., Smith M. T., Cooksley W. G. E., Halliday J. W., Powell L. W. Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function. Clinical Pharmacology and Therapeutics 1990; 47: 516–524
  • Ikeya K., Jaiswal A. K., Owens R. A., Jones J. E., Nebert D. W., Kimura S. Human CYPIA2: sequence, gene structure, comparison with the mouse and rat homologous gene, and differences in iiver mRNA expression. Molecular Endocrinology 1989; 3: 1399–1408
  • Joeres R., Klinker H., Heusler H., Epping J., Zilly W., Richter E. Influence of smoking on caffeine elimination in healthy volunteers and in patients with alcoholic liver cirrhosis. Hepatology 1988; 8: 575–579
  • Lantine R., Bonati M., Castelli D., Garattini S. Dose-dependent kinetics of caffeine in rats. Toxicology Letters 1978; 2: 267–270
  • Matthew D. E., Houston J. B. Drug metabolizing capacity in vitro and in vivo—II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats. Biochemical Pharmacology 1990; 40: 751–758
  • Miller J. L., Clark C. R., Gee S. J., Kreiger R. I. Antipyrine plasma half-like. In vivo indicator of oxidative metabolic capability in Rhesus monkey. Pharmacology 1978; 16: 279–286
  • Nakazawa K., Tanaka H., Arima M. The effect of caffeine ingestion on pharmacokinetics of caffeine and its metabolites after a single administration in pregnant rats. Journal of Pharmacobio-Dynamics 1985; 8: 151–160
  • Park B. K. Assessment of the drug metabolism capacity of the liver. British Journal of Clinical Pharmacology 1982; 14: 631–651
  • Ryan D. E., Levin W. Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacology and Therapeutics 1990; 45: 153–239
  • Tanaka E., Kinoshita H., Yoshida T., Kuroiwa Y. Determination of plasma trimethadione and its metabolite in carbon tetrachloride-intoxicated rat liver: a useful tool for estimation of hepatic drug-metabolizing capacity. Journal of Pharmacobio-Dynamics 1981; 4: 961–967
  • Tanaka E., Kinoshita H., Yoshida T., Kuroiwa Y. Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and α-naphthylisothiocyanate intoxicated rats. Pharmacology 1982a; 25: 202–209
  • Tanaka E., Kinoshita H., Yoshida T., Kuroiwa Y. Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and α-galactosamine intoxicated rats. Japanese Journal of Pharmacology 1982b; 32: 1182–1185
  • Tanaka E., Ishikawa A., Ono A., Okamura T., Kobayashi S., Yasuhara H., Misawa S. Trimethadione tolerance test for evaluation of functional reserve of the liver in patients with liver cirrhosis and esophageal varices. Journal of Pharmacobio-Dynamics 1986a; 9: 297–302
  • Tanaka E., Ishikawa A., Ono A., Takada A., Okamura T., Misawa S. Hepatic trimethadione-oxidizing capacity remains normal in patients with extrahepatic cholelithiasis. Journal of Pharmacobio-Dynamics 1986b; 9: 506–509
  • Wahlländer A., Mohr S., Paumgartner G. Assessment of hepatic function—comparison of caffeine clearance in serum and saliva during the day and at night. Journal of Hepatology 1990; 10: 129–137
  • Wang T., Kleber G., Stellaard F., Paumgartner G. Caffeine elimination: a test of liver function. Klinische Wochenschrift 1985; 63: 1124–1128
  • Welch R. M., Hsu S. Y., DeAngelis R. L. Effect of Aroclor 1254, phenobarbital, and polycylic aromatic hydrocarbons on the plasma clearance of caffeine in the rat. Clinical Pharmacology and Therapeutics 1977; 22: 791–798
  • Vesell E. S., Lee C. J., Passananti G. T., Shively C. A. Relationship between plasma antipyrine half-lives and hepatic microsomal drug metabolism in dogs. Pharmacology 1973; 10: 317–328

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.