Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 5
42
Views
33
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics of ticlopidine during chronic oral administration to healthy volunteers and its effects on antipyrine pharmacokinetics

, , , &
Pages 579-589 | Received 16 Feb 1991, Accepted 16 Sep 1991, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Raghava Choudary Palacharla, Ramakrishna Nirogi, Venkatesham Uthukam, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni & Ilayaraja Kalaikadhiban. (2018) Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims. Xenobiotica 48:7, pages 663-675.
Read now
Jawed Fareed, Walter Jeske & Indermohan Thethi. (2013) Metabolic differences of current thienopyridine antiplatelet agents. Expert Opinion on Drug Metabolism & Toxicology 9:3, pages 307-317.
Read now
Jeffrey S. Berger & Richard C. Becker$suffix/text()$suffix/text(). (2009) A clinician's perspective of emerging P2Y12-directed pharmacotherapies, ex vivo measurement tools, and clinical outcomes. Platelets 20:5, pages 302-315.
Read now
NafizÖ. Can, Göksel Altiokka & HassanY. Aboul-Enein. (2008) Determination of Ticlopidine in Pharmaceutical Tablets by Flow Injection Analysis Using UV-Detection. Journal of Liquid Chromatography & Related Technologies 31:20, pages 3209-3218.
Read now
William W. Johnson. (2008) Cytochrome P450 Inactivation by Pharmaceuticals and Phytochemicals: Therapeutic Relevance. Drug Metabolism Reviews 40:1, pages 101-147.
Read now
Petcharat Dusitanond & Graeme J Hankey. (2004) Ticlopidine. Journal of Drug Evaluation 2:6, pages 163-176.
Read now

Articles from other publishers (27)

Lisa Gross, Dániel Aradi & Dirk Sibbing. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 1253 1267 .
Azizollah Nezhadali & Mahbubeh Esfandiari. (2016) Preparation of a ticlopidine potentiometric sensor and its application to pharmaceutical and biological analysis. Journal of Electroanalytical Chemistry 770, pages 1-5.
Crossref
. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 966 971 .
. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 661 667 .
Swarna Maseneni, Massimiliano Donzelli, Karin Brecht & Stephan Krähenbühl. (2013) Toxicity of thienopyridines on human neutrophil granulocytes and lymphocytes. Toxicology 308, pages 11-19.
Crossref
Si-hyung Yang, Young-ah Cho & Jun-shik Choi. (2011) Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats. Acta Pharmacologica Sinica 32:7, pages 967-972.
Crossref
Richard C. Becker, Jens Lohrmann & Paul Gurbel. 2011. Acute Coronary Syndromes: A Companion to Braunwald's Heart Disease. Acute Coronary Syndromes: A Companion to Braunwald's Heart Disease 201 221 .
Nagy A. Farid, Atsushi Kurihara & Steven A. Wrighton. (2013) Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans. The Journal of Clinical Pharmacology 50:2, pages 126-142.
Crossref
Victoria P. Tan, Bryan P. Yan, Thomas J. Kiernan & Andrew E. Ajani. (2009) Risk and management of upper gastrointestinal bleeding associated with prolonged dual-antiplatelet therapy after percutaneous coronary intervention. Cardiovascular Revascularization Medicine 10:1, pages 36-44.
Crossref
Borja Ibanez, Gemma Vilahur & Juan J. Badimon. (2006) Pharmacology of thienopyridines: rationale for dual pathway inhibition. European Heart Journal Supplements 8:suppl_G, pages G3-G9.
Crossref
I. Kraslova, L. Muchova, L. Vitek, A. Novotny, T. Svestka & R. Bruha. (2016) Ticlopidine-Induced Cholestatic Inflammatory Hepatitis: New Insights into Pathogenetic Mechanisms of Drug-Related Hepatotoxicity. European Journal of Inflammation 4:1, pages 55-67.
Crossref
Ichiro Ieiri, Miyuki Kimura, Shin Irie, Akinori Urae, Kenji Otsubo & Takashi Ishizaki. (2005) Interaction magnitude, pharmacokinetics and pharmacodynamics of ticlopidine in relation to CYP2C19 genotypic status. Pharmacogenetics and Genomics 15:12, pages 851-859.
Crossref
Ney Carter do Carmo Borges, Gustavo Duarte Mendes, Andr� Borges, Sandro Evandir de Oliveira, Rafael Eliseo Barrientos-Astigarraga & Gilberto De Nucci. (2004) Ticlopidine quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Application to bioequivalence study. Journal of Mass Spectrometry 39:12, pages 1562-1569.
Crossref
Alan K Jacobson. (2004) Platelet ADP receptor antagonists: ticlopidine and clopidogrel. Best Practice & Research Clinical Haematology 17:1, pages 55-64.
Crossref
Mar?a Monsalud Arrebola, Jos? Pedro De La Cruz, Mar?a Auxiliadora Villalobos, Araceli Pinacho, Ana Guerrero & Felipe S?nchez de la Cuesta. (2004) In Vitro Effects of Clopidogrel on the Platelet-Subendothelium Interaction, Platelet Thromboxane and Endothelial Prostacyclin Production, and Nitric Oxide Synthesis. Journal of Cardiovascular Pharmacology 43:1, pages 74-82.
Crossref
Petcharat Dusitanond & Graeme Hankey. (2004) Ticlopidine. The Journal of Drug Evaluation 2:6, pages 163-176.
Crossref
José Pedro De La Cruz, Marı́a Monsalud Arrebola, Marı́a Auxiliadora Villalobos, Araceli Pinacho, Ana Guerrero, José Antonio González-Correa & Felipe Sánchez de la Cuesta. (2004) Influence of glucose concentration on the effects of aspirin, ticlopidine and clopidogrel on platelet function and platelet–subendothelium interaction. European Journal of Pharmacology 484:1, pages 19-27.
Crossref
Angelina Pena, Celeste Lino & M.Irene N. Silveira. (2003) Determination of ticlopidine in human plasma by capillary gas chromatography with ion trap detection. Journal of Pharmaceutical and Biomedical Analysis 32:4-5, pages 879-885.
Crossref
Jae Wook Ko, Zeruesenay Desta, Nadia V Soukhova, Timothy Tracy & David A Flockhart. (2001) In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. British Journal of Clinical Pharmacology 49:4, pages 343-351.
Crossref
Tara R. Whetsel & Dawn M. Bell. (2012) Rash in Patients Receiving Ticlopidine after Intracoronary Stent Placement. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 19:2, pages 228-231.
Crossref
Domenico Lapenna, Sergio de Gioia, Giuliano Ciofani, Cristiana Bruno, Ettore Porreca, Sante D Pierdomenico & Franco Cuccurullo. (1998) Antioxidant properties of ticlopidine on human low density lipoprotein oxidation. FEBS Letters 436:3, pages 357-360.
Crossref
Stephen R. Donahue, David A. Flockhart, Darrell R. Abernethy & Jae-Wook Ko. (1997) Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19*. Clinical Pharmacology & Therapeutics 62:5, pages 572-577.
Crossref
Aldo Lagan?Giovanni Bellagamba, Giuseppe D'Ascenzo, Alessandra Gentili & Aldo Marino. (1997) Evaluation of ticlopidine in human serum and plaque by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. Analytica Chimica Acta 354:1-3, pages 87-95.
Crossref
K Róna, K Ary, B Gachályi & I Klebovich. (1997) Liquid chromatographic method for the determination of ticlopidine in human plasma. Journal of Chromatography B: Biomedical Sciences and Applications 693:2, pages 393-398.
Crossref
Tom Buur, Rutger Larsson, Ulf Berglund, Francois Donat & Claude Tronquet. (2013) Pharmacokinetics and Effect of Ticlopidine on Platelet Aggregation in Subjects with Normal and Impaired Renal Function. The Journal of Clinical Pharmacology 37:2, pages 108-115.
Crossref
L. Dal Bo, F. Verga, A. Marzo, L. Ambrosoli & A. Poli. (1995) Determination of ticlopidine in human plasma by high-performance liquid chromatography and ultraviolet absorbance detection. Journal of Chromatography B: Biomedical Sciences and Applications 665:2, pages 404-409.
Crossref
Patricia Flores-Runk & Ralph H. Raasch. (2016) Ticlopidine and Antiplatelet Therapy. Annals of Pharmacotherapy 27:9, pages 1090-1098.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.