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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 6
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Research Article

Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man

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Pages 709-719 | Received 16 Oct 1991, Accepted 13 Feb 1992, Published online: 22 Sep 2008

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Tjerk Bueters, Sanja Juric, Anna-Karin Sohlenius-Sternbeck, Yin Hu & Johan Bylund. (2013) Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human. Xenobiotica 43:7, pages 607-616.
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Henri Roukoz & Walid Saliba. (2007) Dofetilide: a new class III antiarrhythmic agent. Expert Review of Cardiovascular Therapy 5:1, pages 9-19.
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Hanne Elming, Bente Brendorp, Ole Dyg Pedersen, Lars Køber & Christian Torp-Petersen. (2003) Dofetilide: a new drug to control cardiac arrhythmia. Expert Opinion on Pharmacotherapy 4:6, pages 973-985.
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Christian Torp-Pedersen, Bente Brendorp & Lars Køber. (2000) Dofetilide: a class III anti-arrhythmic drug for the treatment of atrial fibrillation. Expert Opinion on Investigational Drugs 9:11, pages 2695-2704.
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Kevin J Ward & Jaswinder S Gill. (1997) Dofetilide: first of a new generation of class III agents. Expert Opinion on Investigational Drugs 6:9, pages 1269-1281.
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J. Brian Houston & David J. Carlile. (1997) Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices. Drug Metabolism Reviews 29:4, pages 891-922.
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M. J. Humphrey. (1996) Application of Metabolism and Pharmacokinetic Studies to the Drug Discovery Process. Drug Metabolism Reviews 28:3, pages 473-489.
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D. K. Walker, K. C. Beaumont, D. A. Stopher & D. A. Smith. (1996) Pharmacokinetics of a series of bis(methanesulphonamido-arylalkyl)amines in the beagle dog. Xenobiotica 26:10, pages 1101-1111.
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Mikael Wallman, Jens Markus Borghardt, Eric Martel, Nicolas Pairet, Michael Markert & Mats Jirstrand. (2022) An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds. Journal of Pharmacological and Toxicological Methods 115, pages 107171.
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Muhammad Erfan Uddin, Xinxin Sun, Kevin M. Huang, Shuiying Hu, Cynthia A. Carnes, Alex Sparreboom & Qiang Fu. (2019) Development and validation of a UPLC-MS/MS analytical method for dofetilide in mouse plasma and urine, and its application to pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 172, pages 183-188.
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Louise Prestipino, Jaimie W. Polson, Elisabeth Brolin & Helen E. Ritchie. (2018) Long-term programming effects on blood pressure following gestational exposure to the I Kr blocker Dofetilide . Physiological Reports 6:5, pages e13621.
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Helen E. Ritchie, Deena H. Ababneh, Diana J. Oakes, Carl A. Power & William S. Webster. (2013) The Teratogenic Effect of Dofetilide during Rat Limb Development and Association with Drug-Induced Bradycardia and Hypoxia in the Embryo. Birth Defects Research Part B: Developmental and Reproductive Toxicology 98:2, pages 144-153.
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T M Haushalter, G S Friedrichs, D L Reynolds, M Barecki-Roach, G Pastino, R Hayes & A S Bass. (2008) The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys. British Journal of Pharmacology 154:7, pages 1457-1464.
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Kristen Bova Campbell, Jennifer D. Mando, Alice L. Gray & Eric Robinson. (2012) Management of Dofetilide Overdose in a Patient with Known Cocaine Abuse. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 27:3, pages 459-463.
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Anusak Kijtawornrat, Yoshinori Nishijima, Brian M. Roche, Bruce W. Keene & Robert L. Hamlin. (2006) Use of a Failing Rabbit Heart as a Model to Predict Torsadogenicity. Toxicological Sciences 93:1, pages 205-212.
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Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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F. A. Brightman, D. E. Leahy, G. E. Searle & S. Thomas. (2006) APPLICATION OF A GENERIC PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO THE ESTIMATION OF XENOBIOTIC LEVELS IN HUMAN PLASMA. Drug Metabolism and Disposition 34:1, pages 94-101.
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Huadong Tang & Michael Mayersohn. (2005) A NOVEL MODEL FOR PREDICTION OF HUMAN DRUG CLEARANCE BY ALLOMETRIC SCALING. Drug Metabolism and Disposition 33:9, pages 1297-1303.
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Shekhar Srivastava, Leon Collis, Anita Go, Salvatore Mancarella, William A Coetzee & Michael Artman. (2005) Paradoxical Effect of Dofetilide on Action Potential Duration and Calcium Transient Amplitude in Newborn Rabbit Ventricular Myocytes. Journal of Cardiovascular Pharmacology 45:2, pages 165-174.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Yuan H Zhao, Michael H Abraham, Joelle Le, Anne Hersey, Chris N Luscombe, Gordon Beck, Brad Sherborne & Ian Cooper. (2003) Evaluation of rat intestinal absorption data and correlation with human intestinal absorption. European Journal of Medicinal Chemistry 38:3, pages 233-243.
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Howard N.E Stevens, Clive G Wilson, Peter G Welling, Massoud Bakhshaee, Julie S Binns, Alan C Perkins, Malcolm Frier, Elaine P Blackshaw, Margaret W Frame, Don J Nichols, Michael J Humphrey & Steve R Wicks. (2002) Evaluation of Pulsincap™ to provide regional delivery of dofetilide to the human GI tract. International Journal of Pharmaceutics 236:1-2, pages 27-34.
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I. Mahmood. (2002) Prediction of Clearance in Humans from In Vitro Human Liver Microsomes and Allometric Scaling. A Comparative Study of the Two Approaches. Drug Metabolism and Drug Interactions 19:1.
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Brian F. Johnson, Shu‐Lin Cheng & Jurgen Venitz. (2013) Transient Kinetic and Dynamic Interactions between Verapamil and Dofetilide, a Class III Antiarrhythmic. The Journal of Clinical Pharmacology 41:11, pages 1248-1256.
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Paul Morgan. (2001) The use of preclinical pharmacokinetic and pharmacodynamic data to predict clinical doses: current and future perspectives. International Congress Series 1220, pages 1-12.
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Iftekhar Mahmood. (2013) Interspecies Scaling: Role of Protein Binding in the Prediction of Clearance from Animals to Humans. The Journal of Clinical Pharmacology 40:12, pages 1439-1446.
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J. Paul MounseyJohn P. DiMarco. (2000) Dofetilide. Circulation 102:21, pages 2665-2670.
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Rodney H. Falk & Jeanne M. DeCara. (2000) Dofetilide: A new pure class III antiarrhythmic agent. American Heart Journal 140:5, pages 697-706.
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Iftekhar Mahmood. (2000) Critique of Prospective Allometric Scaling: Does the Emperor Have Clothes?. The Journal of Clinical Pharmacology 40:6, pages 671-674.
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Dennis J. CadaDanial E. BakerTerri Levien. (2017) Dofetilide. Hospital Pharmacy 35:5, pages 526-535.
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Iftekhar Mahmood. (2013) Prospective Allometric Scaling: Does the Emperor Have Clothes?. The Journal of Clinical Pharmacology 40:4, pages 341-344.
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I. Mahmood. (2000) Can Absolute Oral Bioavailability in Humans be Predicted from Animals? A Comparison of Allometry and Different Indirect Methods. Drug Metabolism and Drug Interactions 16:2.
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James S Kalus & Vincent F Mauro. (2016) Dofetilide: A Class III-Specific Antiarrhythmic Agent. Annals of Pharmacotherapy 34:1, pages 44-56.
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Samantha Abel, Donald J. Nichols, Christopher J. Brearley & Malcolm D. Eve. (2003) Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide. British Journal of Clinical Pharmacology 49:1, pages 64-71.
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Ruey J. Sung & Michael R. LauerRuey J. Sung & Michael R. Lauer. 2000. Fundamental Approaches to the Management of Cardiac Arrhythmias. Fundamental Approaches to the Management of Cardiac Arrhythmias 91 130 .
Lars Frost, Poul Erik Mortensen, Jens Tingleff, Eivind Stoud Platou, Evald Høj Christiansen & Niels Christiansen. (1997) Efficacy and safety of dofetilide, a new class III antiarrhythmic agent, in acute termination of atrial fibrillation or flutter after coronary artery bypass surgery. International Journal of Cardiology 58:2, pages 135-140.
Crossref
S.F. Campbell. 1997. Proceedings XIVth International Symposium on Medicinal Chemistry. Proceedings XIVth International Symposium on Medicinal Chemistry 61 70 .
Takafumi Iwatsubo, Noriko Hirota, Tsuyoshi Ooie, Hiroshi Suzuki, Noriaki Shimada, Kan Chiba, Takashi Ishizaki, Carol E. Green, Charles A. Tyson & Yuichi Sugiyama. (1997) Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. Pharmacology & Therapeutics 73:2, pages 147-171.
Crossref
W. S. Webster, P. D. C. Brown-Woodman, M. D. Snow & B. R. G. Danielsson. (1996) Teratogenic potential of almokalant, dofetilide, andd-sotalol: Drugs with potassium channel blocking activity. Teratology 53:3, pages 168-175.
Crossref
DEBRA S. ECHT, JOHN T. LEE, KATHERINE T. MURRAY, VICKEN VORPERIAN, S. MARCUS BORGANEELI, DIANE M. CRAWFORD, TIEMAN FRIEDRICH & DAN M. RODEN. (2007) A Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Ranging Study of Dofetilide in Patients with Inducible Sustained Ventricular Tachyarrhythmias. Journal of Cardiovascular Electrophysiology 6:9, pages 687-699.
Crossref
Franck Le Coz, Christian Funck-Brentano, Thierry Morell, Mathieu M. Ghadanfar & Patrice Jaillon. (1995) Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization*. Clinical Pharmacology & Therapeutics 57:5, pages 533-542.
Crossref

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