Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 6
265
Views
55
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man

, , &
Pages 709-719 | Received 16 Oct 1991, Accepted 13 Feb 1992, Published online: 22 Sep 2008

References

  • Bastain W., Boyce M. J., Stafford P. B., Clarke D. A., Marlow H. F. Pharmacokinetics of xamoterol after intravenous and oral administration to volunteers. European Journal of Clinical Pharamcology 1988; 34: 469–473
  • Black S. C., Chi L., Mu D.-X., Lucchesi B. R. The antifibrillatory effect of UK-68 798, a class III antiarrhythmic agent. Journal of Pharmacology and Experimental Therapeutics 1991; 258: 41–423
  • Cross P. E., Arrowsmith J. E., Thomas G. N., Gwilt M., Burger R. A., Higgins A. J. Selective class III antiarrhythmic agents. 1. Bis (arylalkyl) amines. Journal of Medicinal Chemistry 1990; 33: 1151–1155
  • Gemmill J. D., Howie C. A., Meredith P. A., Kelman A. W., Rasmussen H. S., Hillis W. S., Elliott H. L. A dose-ranging study of UK-68 798, a novel class III anti-arrhythmic agent, in normal volunteers. British Journal of Clinical Pharmacology 1991; 32: 429–432
  • Gillis A. M., Kates R. E. Clinical pharmacokineticts of the newer antiarrhythmic agents. Clinical Pharmocokinetics 1984; 9: 375–403
  • Guengerich F. P., Macdonald T. L. Chemical mechanisms of catalysis by cytochrome P-450: a unified view. Accounts of Chemical Research 1984; 17: 9–16
  • Gwilt M., Arrowsmith J. E., Blackburn K. J., Burges R. A., Cross P. E., Dalrymple H. W., Higgins A. J. UK-68 798: a novel potent and highly selective antiarrhythmic agent which blocks potassium channels in cardiac cells. Journals of Pharmacology and Experimental Therapeutics 1991; 256: 318–324
  • Latini R., Tognoni G., Kates R. E. Clinical pharmacokinetics of amiodarone. Clinical Pharmacokinetics 1984; 9: 136–156
  • Sedgewick M., Rasmussen H. S., Walker D., Cobbe S. M. Pharmacokinetics and pharmacodynamic effects of UK-68 798, a new potential class III antiarrhythmic drug. British Journal of Clinical Pharmacology 1991; 31: 515–519
  • Smith D. A. Species variations in pharmacokinetics. Drug Metabolism—from Molecules to Man, D. J. Benford, J. W. Bridges, G. G. Gibson. Taylor & Francis, London 1987; 330–351
  • Smith D. A., Humphrey M. J., Charuel C. Design of toxicokinetic studies. Xenobiotica 1990; 20: 1187–1199
  • Smith D. A. Species differences in metabolism and pharmacokinetics: are we close to an understanding?. Drug Metabolism Reviews 1991; 23: 255–274
  • Swabb E. A., Bonner D. P. Prediction of aztreonam pharmacokinetics in humans based on data from animals. Journals of Pharmacokinetics 1983; 11: 215–223
  • Vaughan-Williams E. M. Classification of antiarrhythmic drugs. Symposium on Cardiac Arrhythmias, E. Sandoe, E. Flensted-Jensen, K. H. Oleson. AB Astra, Sodertalje 1970; 449–472
  • Vozeh S., Schmidlin O., Taeschner W. Pharmacokinetic drug data. Clinical Pharmacokinetics Drug Data Handbook 1989, G. J. Mannem. Adis Press Ltd, Auckland 1989; 1–38
  • Walker D. K., Aherne G. W., Arrowsmith J. E., Cross P. E., Kaye B., Smith D. A., Stopher D. A., Wild W. Measurement of the class III antidysrhythmic drug, UK-68 798 in plasma by radioimmunoassay. Journal of Pharmaceutical and Biomedical Analysis 1991a; 9: 141–149
  • Walker D. K., Smith D. A., Stopher D. A. Liquid-liquid extraction and high performance chromatography for the determination of a novel antidysrhythmic agent (UK-68 798) in human urine. Journal of Chromatography 1991b; 568: 475–480

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.