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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 7
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Research Article

Application of 19F.n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor

P. J. Gilbert Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
T. E. Hartley Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
J. A. Troke Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
R. G. Turcan Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
C. W. Vose Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
&
K. V. Watson Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
Pages 775-787 | Received 25 Jul 1991, Accepted 20 Feb 1992, Published online: 22 Sep 2008

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G. J. Dear, I. M. Ismail, P. J. Mutch, R. S. Plumb, L. H. Davies & B. C. Sweatman. (2000) Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in rabbit, mouse and human: identification of fluorine NIH shift metabolites using NMR and tandem MS. Xenobiotica 30:4, pages 407-426.
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K. Sakamoto, Y. Nakamura, S. Aikoh, T. Baba, J. Perregaard, H. Pedersen, E. K. Moltzen, D. J. Mulford & T. Yamaguchi. (1995) Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism. Xenobiotica 25:12, pages 1327-1343.
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J. A. Bell & M. H. Tarbit. (1992) Twenty years on: a review of the current practice of drug metabolism and pharmacokinetic studies in the pharmaceutical industry. Xenobiotica 22:7, pages 735-742.
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Articles from other publishers (7)

R. Lock, P. J. H. Webborn, C. W. Vose & R. M. J. Ings. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry 265 297 .
Emma-Claire ElliottSophie L. ReganJames L. MaggsElizabeth R. BowkettLaura J. ParryDominic P. WilliamsB. Kevin ParkAndrew V. Stachulski. (2012) Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives. Journal of Medicinal Chemistry 55:22, pages 9773-9784.
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Shayne Cox GadJan H. Beumer, Julie L. Eiseman & Merrill J. Egorin. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Peter J Mutch, Gordon J Dear & Issy M Ismail. (2001) Formation of a defluorinated metabolite of a quinoxaline antiviral drug catalysed by human cytochrome P450 1A2. Journal of Pharmacy and Pharmacology 53:3, pages 403-408.
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R. Martino, V. Gilard & M. Malet-Martino. 2008. NMR Spectroscopy in Pharmaceutical Analysis. NMR Spectroscopy in Pharmaceutical Analysis 369 406 .
A. M. Serre, C. Roby, A. Roscher, F. Nurit, M. Euvrard & M. Tissut. (1997) Comparative Detection of Fluorinated Xenobiotics and Their Metabolites through 19 F NMR or 14 C Label in Plant Cells . Journal of Agricultural and Food Chemistry 45:1, pages 242-248.
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J.T. Gerig. (1994) Fluorine NMR of proteins. Progress in Nuclear Magnetic Resonance Spectroscopy 26, pages 293-370.
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