Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 7
Submit an article Journal homepage
16
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Application of 19F.n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor

P. J. Gilbert Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
T. E. Hartley Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
J. A. Troke Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
R. G. Turcan Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
,
C. W. Vose Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
&
K. V. Watson Department of Drug Metabolism, Hoechst Pharmaceutical Research Laboratories, Hoechst UK Ltd., Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
Pages 775-787 | Received 25 Jul 1991, Accepted 20 Feb 1992, Published online: 22 Sep 2008

References

  • Bax A., Freeman R. Investigation of complex networks of spin-spin coupling by two-dimensional n.m.r. Journal of Magnetic Resonance 1981; 44: 542
  • Daly J. W., Jerina D. M., Witkop B. Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds. Experientia 1972; 28: 1129–1149
  • Doddrell D. M., Pegg D. T., Bendall M. R. Distortionless enhancement of n.m.r. signals by polarisation transfer. Journal of Magnetic Resonance 1982; 48: 323–327
  • Everett J. R., Jennings K., Woodnut G. 19F n.m.r. spectroscopy study of the metabolites of flucloxacillin in rat urine. Journal of Pharmacy and Pharmacology 1985; 37: 869–873
  • Gabbay K. H. The sorbitol pathway and the complications of diabetes. New England Journal of Medicine 1973; 288: 831–836
  • Johnson P., Rising P. A., Rising T. J. Liquid scintillation counting of biological samples using extended standardisation and automatic data processing. Liquid Scintillation Counting, M. A. Crook, P. Johnson, B. Scales. Heyden, London 1972; Vol. 2: 267–277
  • Malet-Martino M. C., Martino R. The application of nuclear magnetic resonance spectroscopy to drug metabolism studies. Xenobiotica 1989; 19: 583–607
  • Nicholson J. K., Wilson I. D. Solid-phase extraction chromatography and nuclear magnetic resonance spectrometry for the identification and isolation of drug metabolites in urine. Analytical Chemistry 1987; 59: 2830–2832
  • Nicholson J. K., Wilson I. D. High resolution proton magnetic resonance spectroscopy of biological fluids. Progress in N.M.R. Spectroscopy 1989; 21: 449–501
  • Park Y. H., Hudson J. E., Barker R. C., York B. M., Brazzell R. K. Metabolism of the aldose reductase inhibitor AL01567 in man. British Journal of Clinical Pharmacology 1991; 32: 221–227
  • Park Y. H., Wooldridge C. B., Mattern J., Stoltz M. L., Brazzell R. K. Disposition of the aldose reductase inhibitor AL01576 in rats. Journal of Pharmaceutical Sciences 1988; 77: 110–115
  • Preece N. E., Timbrell J. A. Use of n.m.r. spectroscopy in drug metabolism studies: recent advances. Progress in Drug Metabolism 1990; 12: 147–203
  • Safe S., Jones D., Hutzinger O. Metabolism of 4,4′-dihalogenobiphenyls. Journal of the Chemical Society 1976; 357–359, Perkin I
  • Sato S., Kador P. F. Inhibition of aldehyde reductase by aldose reductase inhibitors. Biochemical Pharmacology 1990; 40: 1033–1042
  • Vialaneix J. P., Malet-Martino M. C., Hoffman J. S., Pris J., Martino R. Direct detection of new flucytosine metabolites in human biofluids by 19F nuclear magnetic resonance. Drug Metabolism and Disposition 1987; 5: 718–724
  • Wade K. E., Troke J., Macdonald C. M., Wilson I. D., Nicholson J. K. 19F studies of the metabolism of trifluoro-methylaniline. Bioanalysis of Drugs and Metabolites, E. Reid, J. D. Robinson, I. D. Wilson. Plenum, London and New York 1988; 383–387

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.