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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 12
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Research Article

Induction of rat hepatic mixed-function oxidases by acetone and other physiological ketones: Their role in diabetes-induced changes in cytochrome P450 proteins

C. R. Barnett Molecular Toxicology Group, Division of Toxicology, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK; Biomedical Sciences Research Centre and Department of Biological and Biomedical Sciences, University of Ulster, Coleraine, Co., Londonderry, BT52 1SA, Northern Ireland, UK
,
L. Petrides Molecular Toxicology Group, Division of Toxicology, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
,
J. Wilson Molecular Toxicology Group, Division of Toxicology, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
,
P. R. Flatt Molecular Toxicology Group, Division of Toxicology, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
&
C. Ioannides Molecular Toxicology Group, Division of Toxicology, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
Pages 1441-1450 | Received 14 Mar 1992, Accepted 24 Jul 1992, Published online: 22 Sep 2008

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Yukiko Minamiyama, Shigekazu Takemura, Yoshihiro Nishino & Shigeru Okada. (2002) Organic nitrate tolerance is induced by degradation of some cytochrome P450 isoforms. Redox Report 7:5, pages 339-342.
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T. Sakuma, R. Honma, S. Maguchi, H. Tamaki & N. Nemoto. (2001) Different expression of hepatic and renal cytochrome P450s between the streptozotocininduced diabetic mouse and rat. Xenobiotica 31:4, pages 223-237.
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COSTAS IOANNIDES. (1999) Effect of diet and nutrition on the expression of cytochromes P450. Xenobiotica 29:2, pages 109-154.
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H. R. SCHOLL & M. M. IBA. (1997) Pharmacokinetics of and CYP1A induction by pyridine and acetone in the rat : interactions and effects of route of exposure. Xenobiotica 27:3, pages 265-277.
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A. Irizar & C. Ioannides. (1995) Extrahepatic expression of P450 proteins in insulin-dependent diabetes mellitus. Xenobiotica 25:9, pages 941-949.
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Dennis V. Parke & Costas Ioannides. (1994) The Effects of Nutrition on Chemical Toxicity. Drug Metabolism Reviews 26:4, pages 739-765.
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J. R. Sneyd, P. J. Simons & B. Wright. (1994) Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient. Xenobiotica 24:10, pages 1021-1028.
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Articles from other publishers (25)

CS Bae & T Ahn. (2022) Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats. Veterinární medicína 67:5, pages 245-256.
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Jin Yu, Hong Zhu, Mark S. Kindy & Saeid Taheri. (2021) Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury. Antioxidants 10:1, pages 52.
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Gökçe Kuzgun, Rahman Başaran, Ebru Arıoğlu İnan & Benay Can Eke. (2020) Effects of insulin treatment on hepatic CYP1A1 and CYP2E1 activities and lipid peroxidation levels in streptozotocin-induced diabetic rats. Journal of Diabetes & Metabolic Disorders 19:2, pages 1157-1164.
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David J. Waxman & Thomas K. H. Chang. 2015. Cytochrome P450. Cytochrome P450 813 850 .
Bienert Agnieszka, Kamińska Agnieszka, Olszewski Jan, Gracz Joanna, Grabowski Tomasz, Wolc Anna & GrzeŚkowiak Edmund. (2012) Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan. Pharmacological Reports 64:2, pages 421-427.
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Rangachari Balamurugan, Antony Stalin & Savarimuthu Ignacimuthu. (2012) Molecular docking of γ-sitosterol with some targets related to diabetes. European Journal of Medicinal Chemistry 47, pages 38-43.
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Bingning Dong, Mohammed Qatanani & David D. Moore. (2009) Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. Hepatology 50:2, pages 622-629.
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Nobuo SASAKI, Noriaki SAKAI, Yoshinori IKENAKA, Tomomi KAMIYA, Min HEEWON, Kentaro Q SAKAMOTO, Mayumi ISHIZUKA & Shoichi FUJITA. (2008) Antibiotic Furazolidone Induces CYP1A But Not CYP2E1 Subfamily in Rat Liver. Journal of Veterinary Medical Science 70:3, pages 223-226.
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Taeho Ahn, Chul-Ho Yun & Doo-Byoung Oh. (2006) Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Toxicology Letters 166:1, pages 27-36.
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Mohamed A. Abdelmegeed, Nicholas J. Carruthers, Kimberley J. Woodcroft, Sang K. Kim & Raymond F. Novak. (2005) Acetoacetate Induces CYP2E1 Protein and Suppresses CYP2E1 mRNA in Primary Cultured Rat Hepatocytes. Journal of Pharmacology and Experimental Therapeutics 315:1, pages 203-213.
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David J. Waxman & Thomas K. H. Chang. 2005. Cytochrome P450. Cytochrome P450 347 376 .
Kouichi Yoshinari, Takeshi Sato, Nao Okino, Junko Sugatani & Masao Miwa. (2004) Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue. Journal of Pharmacology and Experimental Therapeutics 311:1, pages 147-154.
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Zaiqi Wang, Stephen D. Hall, Juan F. Maya, Lang Li, Ali Asghar & J. C. Gorski. (2003) Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans . British Journal of Clinical Pharmacology 55:1, pages 77-85.
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James V. Bruckner, Raghupathy Ramanathan, K. Monica Lee & Srinivasa Muralidhara. (2002) Mechanisms of Circadian Rhythmicity of Carbon Tetrachloride Hepatotoxicity. Journal of Pharmacology and Experimental Therapeutics 300:1, pages 273-281.
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Yukiko Minamiyama, Susumu Imaoka, Shigekazu Takemura, Shigeru Okada, Masayasu Inoue & Yoshihiko Funae. (2001) Escape from tolerance of organic nitrate by induction of cytochrome P450. Free Radical Biology and Medicine 31:11, pages 1498-1508.
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M.P.A Hannon-Fletcher, M.J O'Kane, K.W Moles, Y.A Barnett & C.R Barnett. (2001) Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects. Food and Chemical Toxicology 39:2, pages 125-132.
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Deanna L. Kroetz, Philip Yook, Phillipe Costet, Pascale Bianchi & Thierry Pineau. (1998) Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and Diabetes. Journal of Biological Chemistry 273:47, pages 31581-31589.
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Jacqueline darker Jacquie Snelling, Costas loannides, Peter R. Flat & Christopher R. Barnett. (1996) Effect of vitamin C supplementation on hepatic cytochrome P450 mixed-function oxidase activity in streptozotocin-diabetic rats. Toxicology Letters 89:3, pages 249-256.
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Y. Kiparissis, C.D. Metcalfe & A.J. Niimi. (1996) Induction of hepatic EROD in fish exposed to leachates from wood pulp. Chemosphere 32:9, pages 1833-1841.
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Kazuo Aoki, Wenyuan Zhao, Junichi Misumi, Takato Yasui & Masanobu Kudo. (2006) Changes in 2,5‐Hexanedione Concentration in the Sciatic Nerve, Serum and Urine of Rats Induced by Combined Administration of 2,5‐Hexanedione with Acetone or Methyl Ethyl Ketone. Journal of Occupational Health 38:1, pages 30-35.
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BRUCE I. GAYNES & RICHARD G. FISCELLA. (1996) Biotransformation in Review: Applications in Ocular Disease and Drug Design. Journal of Ocular Pharmacology and Therapeutics 12:4, pages 527-539.
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Amaia Irizar, Christopher R. Barnett, Peter R. Flatt & Costas Ioannides. (1995) Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat. European Journal of Pharmacology: Environmental Toxicology and Pharmacology 293:4, pages 385-393.
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David J. Waxman & Thomas K. H. Chang. 1995. Cytochrome P450. Cytochrome P450 391 417 .
Costas Ioannides, David F. V. Lewis & Dennis V. Parke. 1994. Chemical Safety. Chemical Safety 183 210 .
C.R. Barnett, S. Rudd, P.R. Flatt & C. Ioannides. (1993) Sex differences in the diabetes-induced modulation of rat hepatic cytochrome p450 proteins. Biochemical Pharmacology 45:2, pages 313-319.
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