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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 6
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Research Article

Identification of four biliary metabolites of the diterpene sclareol in the laboratory rat

S. A. Kouzi Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, 38677, USA
,
J. D. McChesney Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, 38677, USA; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, 38677, USA
&
L. A. Walker Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA
Pages 621-632 | Received 22 Jan 1992, Accepted 12 Mar 1993, Published online: 22 Sep 2008

Citations (15)

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SamirA. Kouzi, PatrickF. Dowd & JamesD. McChesney. (1996) Antiinsectan Activity of the Diterpene Sclareol and Analogs Against Fall Armyworm Spodoptera frugiperda . Natural Product Letters 8:3, pages 217-223.
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Articles from other publishers (14)

Mengxue Diao, Chi Li, Jian Lu, Lijun Meng & Nengzhong Xie. (2023) Biotransformation of Sclareol by a Fungal Endophyte of Salvia sclarea . Chemistry & Biodiversity.
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Yutaka Matsumoto & Kazumasa Horikawa. (2022) Transdermal Absorption of Sclareol, an Active Ingredient in Clary Sage Oil: A Complementary and Alternative Medicine for Menopausal Symptoms. Women 2:3, pages 304-312.
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Zheng Xiang, Yuanyuan Chen, Qiming Xiao, Xinwei Yu, Xixi Yu, Zhiyan Hu & Chaojie Wang. (2021) GC-MS/MS method for determination and pharmacokinetics of sclareol in rat plasma after intravenous administration. Journal of Chromatography B 1173, pages 122703.
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Memoona Bibi, M. Iqbal Choudhary & Sammer Yousuf. (2020) Crystal structure and Hirshfeld surface analysis of the methanol solvate of sclareol, a labdane-type diterpenoid. Acta Crystallographica Section E Crystallographic Communications 76:3, pages 294-297.
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. (2015) Scientific Opinion on Flavouring Group Evaluation 18, Revision 3 (FGE.18Rev3): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 13:5.
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Lawrence J. Marnett, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Robert L. Smith, Timothy B. Adams, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2014) GRASr2 Evaluation of Aliphatic Acyclic and Alicyclic Terpenoid Tertiary Alcohols and Structurally Related Substances Used as Flavoring Ingredients. Journal of Food Science 79:4, pages R428-R441.
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Wen-Liang Zeng, Wan-Kui Li, Han Han, Yan-Yan Tao, Li Yang, Zheng-Tao Wang & Kai-Xian Chen. (2014) Microbial Biotransformation of Gentiopicroside by the Endophytic Fungus Penicillium crustosum 2T01Y01. Applied and Environmental Microbiology 80:1, pages 184-192.
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. (2011) Scientific Opinion on Flavouring Group Evaluation 18, Revision 2 (FGE.18Rev2): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 9:5.
Crossref
. (2009) Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1) : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 7:2, pages 978.
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D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes & H. Tagami. (2008) A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients. Food and Chemical Toxicology 46:11, pages S1-S71.
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S.P. Bhatia, D. McGinty, C.S. Letizia & A.M. Api. (2008) Fragrance material review on sclareol. Food and Chemical Toxicology 46:11, pages S270-S274.
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Bharti Sapra, Subheet Jain & A. K. Tiwary. (2008) Percutaneous Permeation Enhancement by Terpenes: Mechanistic View. The AAPS Journal 10:1.
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Wolfgang Engel. (2001) In Vivo Studies on the Metabolism of the Monoterpenes S -(+)- and R -(−)-Carvone in Humans Using the Metabolism of Ingestion-Correlated Amounts (MICA) Approach . Journal of Agricultural and Food Chemistry 49:8, pages 4069-4075.
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Parnali ChatterjeeSamir A. KouziJohn M. Pezzuto & Mark T. Hamann. (2000) Biotransformation of the Antimelanoma Agent Betulinic Acid by Bacillus megaterium ATCC 13368 . Applied and Environmental Microbiology 66:9, pages 3850-3855.
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