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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 6
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Research Article

Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes

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Pages 681-692 | Received 10 Nov 1992, Accepted 20 Mar 1993, Published online: 22 Sep 2008

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Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu & Hiroshi Yamazaki. (2023) Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation. Xenobiotica 53:6-7, pages 465-473.
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Kazutaka Sekiguchi, Takushi Kanazu, Masaharu Takeuchi, Hiroshi Hasegawa & Yoshitaka Yamaguchi. (2014) Non-clinical evaluation of the metabolism, pharmacokinetics and excretion of S-777469, a new cannabinoid receptor 2 selective agonist. Xenobiotica 44:1, pages 48-58.
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D. D. Surry, G. Meneses-Lorente, R. Heavens, A. Jack & D. C. Evans. (2000) Rapid determination of rat hepatocyte mRNA induction potential using oligonucleotide probes for CYP1A1, 1A2, 3A and 4A1. Xenobiotica 30:5, pages 441-456.
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Y. NISHIBE, M. WAKABAYASHI, T. HARAUCHI & K. OHNO. (1998) Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver. Xenobiotica 28:6, pages 549-557.
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I. SchaeffnerJ. PettersH. AurichP. FrohbergB. Christ. (2005) A Microtiterplate-Based Screening Assay to Assess Diverse Effects on Cytochrome P450 Enzyme Activities in Primary Rat Hepatocytes by Various Compounds. ASSAY and Drug Development Technologies 3:1, pages 27-38.
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Magang Shou, Ryan Norcross, Grit Sandig, Ping Lu, Yinghe Li, Yuh Lin, Qin Mei, A. David Rodrigues & Thomas H. Rushmore. (2003) SUBSTRATE SPECIFICITY AND KINETIC PROPERTIES OF SEVEN HETEROLOGOUSLY EXPRESSED DOG CYTOCHROMES P450. Drug Metabolism and Disposition 31:9, pages 1161-1169.
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Jay Tibbitts. (2016) Issues Related to the Use of Canines in Toxicologic Pathology—Issues With Pharmacokinetics and Metabolism. Toxicologic Pathology 31:1_suppl, pages 17-24.
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Richard A. Graham, April Downey, Dan Mudra, Linda Krueger, Kathy Carroll, Christopher Chengelis, Ajay Madan & Andrew Parkinson. (2002) In Vivo and in Vitro Induction of Cytochrome P450 Enzymes in Beagle Dogs. Drug Metabolism and Disposition 30:11, pages 1206-1213.
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C Eeckhoutte, A Giuliano Albo, M Carletti, A Rossetto Giaccherino, P Galtier, C Nebbia & M Dacasto. (2002) Time-dependent variations of drug-metabolising enzyme activities (DMEs) in primary cultures of rabbit hepatocytes. Toxicology in Vitro 16:4, pages 375-382.
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Robert A Coleman, Wayne P Bowen, Ian A Baines, Amanda J Woodrooffe & Anthony M Brown. (2001) Use of human tissue in ADME and safety profiling of development candidates. Drug Discovery Today 6:21, pages 1116-1126.
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Genevieve Ubeaud, Claus-Ditter Schiller, Fabrice Hurbin, Daniel Jaeck & Philippe Coassolo. (2001) Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers. European Journal of Drug Metabolism and Pharmacokinetics 26:1-2, pages 37-45.
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Michael Sinz. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 401 424 .
M. Monshouwer, G.A.E. van't Klooster, S.M. Nijmeijer, R.F. Witkamp & A.S.J.P.A.M. van Miert. (1998) Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes. Toxicology in Vitro 12:6, pages 715-723.
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F Fontaine, G de Sousa, P Duchene & R Rahmani. (1998) Cytochrome P450 Induction and Cytotoxic effects of Antimalarials in Rat Hepatocytes. Toxicology in Vitro 12:5, pages 545-549.
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Julio C. Davila, Rosita J. Rodriguez, Russell B. Melchert & Daniel AcostaJr.Jr.. (1998) PREDICTIVE VALUE OF IN VITRO MODEL SYSTEMS IN TOXICOLOGY. Annual Review of Pharmacology and Toxicology 38:1, pages 63-96.
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William B. Mattes & Albert P. Li. (1997) Quantitative reverse transcriptase/PCR assay for the measurement of induction in cultured hepatocytes. Chemico-Biological Interactions 107:1-2, pages 47-61.
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G. de Sousa, S. Langouët, F. Nicolas, G. Lorenzon, M. Placidi, R. Rahmani & A. Guillouzo. (1996) Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation. Cell Biology and Toxicology 12:4-6, pages 351-358.
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MN Nanjee, H Verhagen, G van Poppel, CJ Rompelberg, PJ van Bladeren & NE Miller. (1996) Do dietary phytochemicals with cytochrome P-450 enzyme-inducing activity increase high-density-lipoprotein concentrations in humans?. The American Journal of Clinical Nutrition 64:5, pages 706-711.
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D. Müller, R. Glöckner & M. Rost. (1996) Monooxygenation, cytochrome P4501A1 and P4501A1-mRNA in rat liver slices exposed to beta-naphthoflavone and dexamethasone in vitro. Experimental and Toxicologic Pathology 48:5, pages 433-438.
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Yasuhiro Nishibe & Masaharu Hirata. (1995) Induction of Cytochrome P-450 isoenzymes in cultured monkey hepatocytes. The International Journal of Biochemistry & Cell Biology 27:3, pages 279-285.
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R. Glöckner & D. Müller. (1995) Ethoxycoumarin O-deethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro. Experimental and Toxicologic Pathology 47:4, pages 319-324.
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