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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 5
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Research Article

Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat

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Pages 429-440 | Received 05 Aug 1993, Accepted 11 Nov 1993, Published online: 22 Sep 2008

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Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre & Suramya Waidyanatha. (2018) Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro. Xenobiotica 48:11, pages 1142-1156.
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Hyun Jung Koo & Byung Mu Lee. (2005) Human Monitoring of Phthalates and Risk Assessment. Journal of Toxicology and Environmental Health, Part A 68:16, pages 1379-1392.
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J. C. ENGLISH, P. J. DEISINGER & D. GUEST. (1998) Metabolism of 2-ethylhexanoic acid administered orally or dermally to the female Fischer 344 rat1. Xenobiotica 28:7, pages 699-714.
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Yu-Ning Hu, Jin-Tao Zhan, Pei-Rong Bai, Na An, Jun-Jie Tan, Yan-Zhen Wang, Quan-Fei Zhu & Yu-Qi Feng. (2023) In-depth profiling of di(2-ethylhexyl) phthalate metabolic footprints in rats using click chemistry-mass spectrometry probes. Journal of Hazardous Materials 452, pages 131190.
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David Hala, Lene H. Petersen, Duane B. Huggett, Michelle A. Puchowicz, Henri Brunengraber & Guo-Fang Zhang. (2021) Overcompensation of CoA Trapping by Di(2-ethylhexyl) Phthalate (DEHP) Metabolites in Livers of Wistar Rats. International Journal of Molecular Sciences 22:24, pages 13489.
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Karen L. Blackburn, Gregory Carr, Jane L. Rose & Bastian G. Selman. (2020) An interim internal Threshold of Toxicologic Concern (iTTC) for chemicals in consumer products, with support from an automated assessment of ToxCast™ dose response data. Regulatory Toxicology and Pharmacology 114, pages 104656.
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Takanari Wakayama, Yuki Ito, Kiyoshi Sakai, Mio Miyake, Eiji Shibata, Hiroyuki Ohno & Michihiro Kamijima. (2019) Comprehensive review of 2‐ethyl‐1‐hexanol as an indoor air pollutant. Journal of Occupational Health 61:1, pages 19-35.
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Bernd Rossbach, Peter Kegel & Stephan Letzel. (2018) Urinary excretion of heptanones, heptanoles and 2,5-heptanedione after controlled acute exposure of volunteers to n-heptane. Toxicology Letters 298, pages 81-90.
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Terry W. Schultz, Katarzyna R. Przybylak, Andrea-Nicole Richarz, Claire L. Mellor, Steven P. Bradbury & Mark T.D. Cronin. (2017) Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected 2-alkyl-1-alkanols. Computational Toxicology 2, pages 28-38.
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Gabriel A. Knudsen, J. Michael Sanders & Linda S. Birnbaum. (2016) Disposition of the Emerging Brominated Flame Retardant, 2-Ethylhexyl 2,3,4,5-Tetrabromobenzoate, in Female SD Rats and Male B6C3F1 Mice: Effects of Dose, Route, and Repeated Administration. Toxicological Sciences 154:2, pages 392-402.
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A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, Y. Miyachi, V.T. Politano, G. Ritacco, D. Salvito, T.W. Schultz, J. Shen, I.G. Sipes, B. Wall & D.K. Wilcox. (2016) RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0. Food and Chemical Toxicology 97, pages S157-S167.
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A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, T.M. Penning, V.T. Politano, G. Ritacco, D. Salvito, T.W. Schultz, J. Shen, I.G. Sipes, B. Wall & D.K. Wilcox. (2016) RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7. Food and Chemical Toxicology 97, pages S147-S156.
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A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, T.M. Penning, V.T. Politano, G. Ritacco, D. Salvito, T.W. Schultz, J. Shen, I.G. Sipes, B. Wall & D.K. Wilcox. (2016) RIFM fragrance ingredient safety assessment, 2-methylundecanol, CAS Registry Number 10522-26-6. Food and Chemical Toxicology 97, pages S119-S128.
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Yuri Dancik, John A Troutman & Joanna Jaworska. (2013) A framework incorporating the impact of exposure scenarios and application conditions on risk assessment of chemicals applied to skin. In Silico Pharmacology 1:1.
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Lillian C. 'Becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. MarksJrJr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. (2013) Safety Assessment of Alkyl Benzoates as Used in Cosmetics. International Journal of Toxicology 31:6_suppl, pages 342S-372S.
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Chris Bevan. 2003. Patty's Toxicology. Patty's Toxicology 1 54 .
. (2012) Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30. EFSA Journal 10:3.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 136 178 .
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D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes & H. Tagami. (2010) A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. Food and Chemical Toxicology 48, pages S1-S46.
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D. McGinty, J. Scognamiglio, C.S. Letizia & A.M. Api. (2010) Fragrance material review on 2-ethyl-1-hexanol. Food and Chemical Toxicology 48, pages S115-S129.
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. (2009) Flavouring Group Evaluation 04 −2-Ethylhexyl derivatives from chemical group 2 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 7:1, pages 929.
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. (2005) Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturate. EFSA Journal 3:12, pages 246.
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Hans Günther Wahl, Qunfa Hong, Dolores Stübe, Martin E Maier, Hans-Ulrich Häring & Hartmut M Liebich. (2001) Simultaneous analysis of the di(2-ethylhexyl)phthalate metabolites 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 758:2, pages 213-219.
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C. Bevan Ph.D. 2003. Patty's Toxicology. Patty's Toxicology.
Graham A Mills & Valerie Walker. (2001) Headspace solid-phase microextraction profiling of volatile compounds in urine: application to metabolic investigations. Journal of Chromatography B: Biomedical Sciences and Applications 753:2, pages 259-268.
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Valerie Walker & Graham A Mills. (2001) Urine 4-heptanone: a β-oxidation product of 2-ethylhexanoic acid from plasticisers. Clinica Chimica Acta 306:1-2, pages 51-61.
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Hans Günther Wahl, Andreas Hoffmann, Hans-Ulrich Häring & Hartmut M Liebich. (1999) Identification of plasticizers in medical products by a combined direct thermodesorption–cooled injection system and gas chromatography–mass spectrometry. Journal of Chromatography A 847:1-2, pages 1-7.
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I.C Munro, E Kennepohl & R Kroes. (1999) A procedure for the safety evaluation of flavouring substances. Food and Chemical Toxicology 37:2-3, pages 207-232.
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T.B. Adams, D.B. Greer, J. Doull, I.C. Munro, P. Newberne, P.S. Portoghese, R.L. Smith, B.M. Wagner, C.S. Weil, L.A. Woods & R.A. Ford. (1998) The FEMA GRAS Assessment of Lactones Used as Flavour Ingredients. Food and Chemical Toxicology 36:4, pages 249-278.
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H.-J. Klimisch, K. Deckardt, C. Gembardt & B. Hildebrand. (1998) Subchronic inhalation toxicity study of 2-ethylhexanol vapour in rats. Food and Chemical Toxicology 36:3, pages 165-168.
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